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Summary Expression Gene Literature (44) GO Terms (4) Nucleotides (193) Proteins (38) Interactants (598) Wiki
XB-GENEPAGE- 493519

Gene Symbol: axin2

Gene Name: axin 2 (conductin, axil)

Synonyms: axil , xarp
Add Xenopus synonyms , Nomenclature history


Gene Function: G protein signaling regulator

Protein Function:
Regulates the wnt signaling pathway by interacting with dvl2/dsh, which displaces gsk3b from the axnr-gsk3b complex and thus prevents degradation of ctnnb1/beta-catenin.


Interactants: Loading ...

OMIM Disease Associations: COLORECTAL CANCER; CRC [+]
 
Xenbase Gene ID XB-GENE-6449828 XB-GENE-6252887 XB-GENE-6253409
Gene Symbol axin2 axin2.L axin2.S
Chromosome Chr07 chr7L chr7S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq Refseq
Protein NCBI Protein Refseq Swiss-Prot TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.5833 Str.43160 [+] Xl.610 [+] Xl.16177
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 6 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine axin2 axin2.L axin2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards AXIN2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Axin2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN axin2 ZFIN Ensembl
chicken
GEISHA AXIN2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos. [Mol Cell Biol 1998]
Most recent: Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. [Dev Cell 2017]
View All Papers 8 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 4 terms 1 terms
EC
PANTHER axin2
KEGG Pathways K04385 K04385
KOG [T] G protein signaling regulators
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s)    
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
ORF axin2 ORF1
Affymetrix 1.0 Str.45042.1.A1_s_at [+] Xl.610.1.S1_at Xl.16177.1.A1_at
Affymetrix 2.0 Xl2.610.1.A1_at Xl2.16177.1.S1_at [+]

Symbol legend[+]

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