plk4 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (5)

Nucleotides (119)

Interactants (7)

XB-GENEPAGE-493607

Gene Symbol: plk4 Gene Name: polo-like kinase 4 Synonyms: plx4 Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: plk1(3) , cdk2(1) , cep152(1) , mapk1(1) , mos(1) , plk2(1) , plk3(1) View All

XB-GENE-493608

XB-GENE-866273

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001128656\|Xenopus (Silurana) tropicalis polo-like kinase 4 (plk4), mRNA GTTCACGTGACTGTAACGGGCGGAATTTTTGAAATTTCTATCTGTTAGTGCGAGAAGCGCGGAAATGTATCGGGGGCCCGCGAGCCCGACCTACTGCCAGCTGGATCACGTGACGGCCGCCGCCGCCGGGTTCCCTATCCCCGCCGCTACGGAGTGGCGTGCGGTCAATCGAGGACGATGAACCGGGAGCGAGCAGCGAGAGAAAAACAGCATGGCTGGCAGCATAGGGGAGAGGAGAGAGGACTTCAAAGTTCTCAATCTCCTTGGCAAAGGCTCGTTTGCCTGTGTGTACAGGGCCCAGTCTATCAACACTGGCATCGATGTAGCCATCAAAATGATAGACAAAAAAGCCATGCAGAAGGTTGGAATGGTGCAGAGAGTCCGAAATGAAGTTGAGATCCATTGTCAGTTAAAACACCCTTCTATCCTGGAGCTGTATAATTATTTTGAAGACAGCAATTATGTGTATCTGATTCTTGAGATGTGCCACAATGGGGAGATGAACAGGTTTTTAAAGAACAGGAAAAAACCTTTCTCTGAAGATGAAGCCCGTCATTTTATGCACCAAATTGTTACCGGAATGCTGTATCTCCATTCACATGGTATATTACATCGGGATCTTACCCTTTCCAATCTACTGCTGTCTAGTGACATGAATATCAAAATTGCAGATTTTGGCTTAGCAACTCAGTTGAAAATGCCAAATGAGAAGCATTTTACTATGTGTGGCACACCAAACTACATTGCTCCTGAAATTGCTACACGGAGTGCTCATGGCCTTGAGTCAGATGTCTGGTCCTTGGGATGTATGCTGTATACTTTTCTTGTTGGAAGACCACCTTTTGACACAGACACTGTAAAGAATACGCTGAATAAAATTGTACTGGCAGACTATGAAATGCCTGACTTTGTGTCAAGGGAGGCCAAAGACTTAATATTTCAGTTGCTAAGAAAAAACCCAGCAGATCGGTTAAGCCTTTCATCAGTTTTAGACCATGCATTTATGACTGGTTTCTCTAATGTCCAAAGTAAAGTTATGGGAGCTGTTGAGGACTCCATTGATAGTGGGCATGCTACAATCTCCACTGGTTTCACTGGCTCTTCTGGAGTTAGTATAAGTGGGCGTTTTCAGGAGAAAAGGATCTTGTCTGGCCCTTCCCTCCCTAACAAAGTCAATATATTCCAATTTAAGGATAAGCATCCTGCTGAAAGATCAAATGGTGGAAGCTTTCATAATACACAGAGGGAAAATAATGACTTTTCTGAGGGCAATGGAAGGAAAACTGTTGCCTGTGAGGACAGACCACATTCTCGTTACCTGCGAAGGGCTCATTCCTCTGACAGGTCAGGAACTTCTCAAAGCCAAACTTATGGTAAACCAAGCAGCTTTTCAGAGAGGTGCCATTCAGTGGAGATGCTTGCTAAACCAAGTAATTTAAAGGGCTATTGTACTTCTTCGCCACCTAAAAGCTATGGAGATATTCCACAGATGTTTACAGATGAACGTTCTTTGGAGAGACACACTTCTCCCCCAGTAAAAGAAAAAACCCCTTCTGAGTTCATGTGCCCAGCAAAGCAAATTACTCCAAGATCTGGCGATAAGTGCCAAGCTGAAACTGTTCAACAGTGGTTTGGAGCAATGCAACTAAATGGTAAATTTAAAAATACGCCAGATACAAGCAGTGTTAGTAACATGGGTGGAGATTTCTACAGCCAACAGACCATGCAAAATGGAGCTCCACAATATGCCTGGAATGATGTAAAGAGGAAAAAAGATACAGACTCCTCCGTTGAGAGTGTCTTGCGAGGAATAAGTAAACTCCCTTCTGGACAGCACAAGGCTGAAAAAAGTCAGTTTGGGGAGCAGAGCAAAGCCAGGGTACCACAGCAGGCATTTGGATCCAGTACCCTGCGATCCATTATTTCTCCATTAAATGCGGAAAGATTGAAACCAATCAGACAAAAAACAAAGAATGCAGTGGTTAGTATCCTTGAGACCGGAGAAGTCTGTATGGAATTCCTAAAAGAGCAAAATTCTCAAGAACGTGTAAAAGAGGTGTTAAGGATATCTTGTGATGGAAATTTGATTTATGTGTATCATCCAAATGAAGGGAAAGGTTTTCCTTTAGTTGAGAGACCTCCATCTCCTCCAGAAAACATGCGCAGTTACACTTTTGACAGTTTACCAGAAAAATATTGGAAAAAATATCAGTATGCTGCAAAGTTCATACAACTCGTACGATCTAAAATGCCAAAGGTTACCTACTACACAAGATACGCAAAGTGTATGTTAATGGAAAATGGTCCCAATGCTGATTTTGAAGTCTGCTTCTATGATGGAGCAAAGATCCATAAGACCCCTGATTTGATAAGAGTCATAGAGAAATCTGGAAAATCATACACTGTGGAAGGGAGTAGATTGAGCACCTTGTCTGATCAAGTTCGATCGTATGTGAATCATGCCAATGAGAGCCATTGCGTTTGCCTTTCTTTGGAATCTGCAATCAACACAGAGGAGAAAAAGGGTGAAAATATTTCTTTGTTTCCAATAACGTTTGGCAGGAGGCCAGCTATAACAGAATCTCCTAGGACACAACTAACTGTAGATAGTGCTAGAGAAAGAAAAGATGAGCAGAGTTCTGCTAACAGAGTATTACACAGCAGTGCAACGTCTCCACCCCAGATACCTAACATTAATCCCTCTCTTATTTCCTATGAGGGTTCTGTATTCTCTGCTACCACCGCCCAACCTTCACCACCTACTTCAAATACTCTCAAGACTCATGCTCCAGATCGTGCTCAGGTCCTAAAATCTGTTTTTGTTGAAAATGTAGGCTGGGCATCTCAGTTAAACAGTGGAGCAGTATGGGTCCAGTTCAATGATGGATCACAACTTGTTGTTCAACCAGGGGTCTCCTCCATAATTTATACCGCACCGAATGGACAGATAACAAGACATGGGGAGAATGACAAACTTCCAGAGTACATCAAAAGCAAGTTGCAGTGTCTCTCCTCCATTCTAATGCTCTTTGCAAGTTCATCAAGTCACTAATGAGAGAAAGGCAGTGCCGTACAACACAACCACAATTTGCCAAATGAATGCAAGCCTTCAGAAGTGCTATGGAAAAGTAGTGCCTGCTGAGCCCTGTGATCTCTGTTGGCTATAAAATACCAGCCTCCCCTGGATTCTGTCTCATCACAGCATTTGTGTTGCCATTCAATAGGCAGCTCATTTTCTTTGTAAATATAAAAAGTAACACTTCTAGTATTTTGTGATAATGTCTTTCTTCAGATTCCTTTAATGTATTTTTCTACTGTAAGTTGGGGGGTTCAGTCATTTATATCATGAATGTCACATCTTTTACTATATATTTGTACATGTAAATGTTGTATGTTTTGTACAATTCAAAAAGTATATTTTTTATTTTTGTTAACTTATTTTGTATTCACAGTTTAACAAAATATTACTGCAACAACAAAACAATTAAAAGCTGCAGTGAAATAAAAAAAAAAAAAAAAAAA	Refseq >NM_001089677\|Xenopus laevis polo-like kinase 4 (plk4), mRNA AATTTTTTGAAATCTCTATCGGATCGTGAGAGAAACGCGGAAATGGATCGAGGGCCCGCGAGCCCGACCCGTCGCCAGCTGGATCACGTCACGGCCGCCGCCAGATTCCTTATCCCCGCCGCTGAGGAGTGGCGCGCGGTCTATCGAGGATGATGAGCCGGGCGCGAGCAGCGAGAGAAAAAGAGCATGGCGGGCAGCATAGGAGAGAGGAGAGAGGACTTCAAAGTTCTCAATCTCCTCGGCAAAGGCTCATTTGCCTGTGTGTACAGGGCCCAGTCTATCAACACTGGCATCGATGTAGCCATCAAAATGATCGACAAAAAAGCTATGCAGAAGGTTGGAATGGTGCAGAGAGTCCGAAATGAAGTCGAGATCCATTGTCAGTTAAAACACCCTTCTATTCTGGAGCTGTATAATTACTTTGAAGACAGCAACTATGTATATCTGATTCTCGAGATGTGCCACAATGGGGAGGTGAACAGGTATTTAAAGAATAGGAAGAAACCTTTCGCTGAAGATGAAGCCCGGCATTTCATGCACCAAATTGTCACAGGAATGCTGTATCTTCATTCACACGGTATATTACATCGGGACCTCACCCTTTCCAACCTACTGTTGTCTAGTGACATGAATATCAAAATTGCAGATTTTGGCCTGGCAACTCAGTTGAAAATGCCAAATGAGAAACATTTTACCATGTGTGGCACACCAAACTATATTGCTCCTGAAATTGCTACACGGAGTGCTCATGGTCTTGAGTCGGATGTCTGGTCCTTGGGATGTATGCTGTATACTTTCCTTGTTGGAAGACCACCTTTTGACACAGACACTGTAAAGAATACACTGAATAAAATTGTACTGGCAGACTATGAAATGCCTGACTTTGTGTCAAGGGAGGCCAAAGACCTGATTTTTCAGTTGTTACGAAAAAACCCAGCAGATCGGTTAAGTCTTTCATCAGTTTTGGACCATGCATTCATGACCGGTTTCTCCAATGTCCAAAGTAAAGTTATGGGAGCTGTTGAGGACTCCATGGACAGTGGGCATGCTACAATATCTACTGGTTTCACTGGGTCTTCTGGGGTAAGTATAAGTGGCCGTTTTCAGGAGAAAAGAATCTTGTCTGGCCCTTCGCTCCCCAACAAAGTCAATATCTTCCAATTTAAGGATAAACATCCTACTGAAAGATCAAATGGTGGAAGCTTTCATAATACACAAAGGGAAAATAATGACTTTTCTGAGGGCAATGGAAGGAAACCTGTTGCCTGTGAGGACAGACCACATTCGCGTTACCTGCGAAGGGCTCATTCATCTGACAGGTCAGGAACCTCTCAAAGTCAAACTTATGCTAAACCAAGCAGCTATTCAGAGCGGTGCCATTCAGTGGAGATGCTTGCTAAACCCACTCATTTAAAGGGCTACCGCACTTCTTCACCTCCCAACAGCTATGGAGACATACCACAGATGTTCACAGATGAACGTTCTTTGGAGAGGCACACTTCTCCTCCAGTGAAAGAAAAAACACCTTCTGAGTTCATGGGCCCAGCAAAGCAAACTGCCCCAAGATCTAATGACAAAGCTGAAACTGTTCAGCAGTGGTTTGGAGCGATGCAACTGAATGGTCAATTTAAAAATACGCCGGATACCAGCAGTGTTAGTAACATGGGTGGAGATTTCTACAGCCAACAGGCCACTCAAAATGGCGCGCCACAATATGCTTGGAACGATGTAAAGAGGAAAAAAAATACAGACTCCTCTATTGAGAGTGTTCTGCTAGGAATAAAAAAAAATCCTGGTACAGGCCAGCGCAAGGCAGAAAAAAGTCAATTTGGGGAGCAGAGCAAATCCAGGGTACCACAGCAGGCATTTGGATCCAGTACCCTGAGATCCATCATTTCTCCACTGAATGCAGAAAGATTGAAACCAATCAGACAGAAAACAAAGAATGCAGTGGTTAGTATCCTTGAGTCGGGAGAAGTCTGTATGGAGTTTCTAAAAGAGCAAAATTCTCAAGAACGTGTTAAAGAAGTGTTAAGGATATCTTGTGATGGAAATTTGATTTATGTGTATCACCCAAATGAAGGGAAAGGTTTTCCTCTAGTTGACCGACCTCCATCTCCTCCAGAAAACAGGCTCAGTTACACCTTTGACAGTTTACCAGAAAAATACTGGAAAAAATATCAGTATGCTGCAAAATTTATAAAACTTGTACGATCTAAAACGCCAAAGGTTACCTACTATACGAGATATGCCAAGTGTATGTTAATGGAGAATAGTCCCACTGCTGATGTTGAAGTCTGTTTCTATGATGGAGCAAAGATCCATAAGACTTCTGATGTAATAAGGGTAATAGAGAAATCTGGGAGATCGTACACACTGGAAGGGAGTCGGCTGAGCACCTTGTCCGATGAAGTTCGATCTTATTTGGATCATGCCAATGAGAGCCATTGCGTTTGCCTGTCTTTGGAATCTGCAATCAACACAGAGGAGAAAAAGGGTGAAAATATTTCTTTGTTTCCAATTACGTTTGGCAGGAGGCCAGCTTTAGCAGAATCACCAAAGACACAGCCAACACCTTCTGTGGATAGTGCTAGAGAAAGAAAAGAAGAGCAGAGTTATGTTAACAGAGTATTACATGGCAGTGCAGCTTCCCCACCCCAGATGCCTAATCTCAATCCCTCTCTGATTTCCTATGATGGTTCTGTATTCTCTGCTACCACCGTGCAACCTTCACCTACTTCAAATATCCACAATACTCCAGATCATGCTCAAGTCCTAAAATCTGTTTTTGTTGAAAATGTAGGCTGGGCATCTCAGTTAAACAGTGGAGCAGTATGGGTCCAGTTCAATGATGGATCTCAACTTGTTGTTCAACCAGGGGTCTCCTCCATTATTTATACCGCACCAAACGGCCAGATAACAAGGCATGGAGAGAATGACAAACTTCCAGAGTACATCAAAAGCAAGCTGCAGTGTCTCTCCTCCATTCTAATGCTCTTTGCCAGCTCGTCCAGTCGCTAATGGGAAAACGTAACTTTCAACACAAGCCACCATTTACCAGATGAATATAAGCCCCTTCAGTACAATACAATACAATACAATAGTGCTTGCTGAGCCTTGTGATCACTATTCACTATGAAATGCCAACCTCCCCTGGATTCAATCTCATCACAGCATTTATATTGCCATTCAATAGGCAGCCTATTTTTTTGTAAATATAAAAATTAACATTTATAGCGTTTTGTGACCATGTCATTCTTCAGATTCCTTCAATGTAATGTTTTACTGTCCGTTGTGGGTGCGGGGGGCAGTCGTGAATATCATGGAAGTCTTGTTTCACTCTATTTTTGTACATGTAAATGTTGTATTTTTATGTAAAATTCTAAAGTATATTTTTTATTTTTGTTAACTTATTTTGTATTCACAGTTTCTAATGAAATATTACTGCAACTTCCAAAACATTAAAAAAAAAGTGCAGCGACGTGATTCTTAACTTTATTCCCATTAAATGGTTTTATTCTAATAAAGGATCAGAGGTTAAAAAAAAAAAAAAA
Protein		Refseq >NP_001122128\|serine/threonine-protein kinase PLK4 [Xenopus (Silurana) tropicalis] MAGSIGERREDFKVLNLLGKGSFACVYRAQSINTGIDVAIKMIDKKAMQKVGMVQRVRNEVEIHCQLKHPSILELYNYFEDSNYVYLILEMCHNGEMNRFLKNRKKPFSEDEARHFMHQIVTGMLYLHSHGILHRDLTLSNLLLSSDMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLESDVWSLGCMLYTFLVGRPPFDTDTVKNTLNKIVLADYEMPDFVSREAKDLIFQLLRKNPADRLSLSSVLDHAFMTGFSNVQSKVMGAVEDSIDSGHATISTGFTGSSGVSISGRFQEKRILSGPSLPNKVNIFQFKDKHPAERSNGGSFHNTQRENNDFSEGNGRKTVACEDRPHSRYLRRAHSSDRSGTSQSQTYGKPSSFSERCHSVEMLAKPSNLKGYCTSSPPKSYGDIPQMFTDERSLERHTSPPVKEKTPSEFMCPAKQITPRSGDKCQAETVQQWFGAMQLNGKFKNTPDTSSVSNMGGDFYSQQTMQNGAPQYAWNDVKRKKDTDSSVESVLRGISKLPSGQHKAEKSQFGEQSKARVPQQAFGSSTLRSIISPLNAERLKPIRQKTKNAVVSILETGEVCMEFLKEQNSQERVKEVLRISCDGNLIYVYHPNEGKGFPLVERPPSPPENMRSYTFDSLPEKYWKKYQYAAKFIQLVRSKMPKVTYYTRYAKCMLMENGPNADFEVCFYDGAKIHKTPDLIRVIEKSGKSYTVEGSRLSTLSDQVRSYVNHANESHCVCLSLESAINTEEKKGENISLFPITFGRRPAITESPRTQLTVDSARERKDEQSSANRVLHSSATSPPQIPNINPSLISYEGSVFSATTAQPSPPTSNTLKTHAPDRAQVLKSVFVENVGWASQLNSGAVWVQFNDGSQLVVQPGVSSIIYTAPNGQITRHGENDKLPEYIKSKLQCLSSILMLFASSSSH UniProtKB	Refseq >NP_001083146\|serine/threonine-protein kinase PLK4 [Xenopus laevis] MAGSIGERREDFKVLNLLGKGSFACVYRAQSINTGIDVAIKMIDKKAMQKVGMVQRVRNEVEIHCQLKHPSILELYNYFEDSNYVYLILEMCHNGEVNRYLKNRKKPFAEDEARHFMHQIVTGMLYLHSHGILHRDLTLSNLLLSSDMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLESDVWSLGCMLYTFLVGRPPFDTDTVKNTLNKIVLADYEMPDFVSREAKDLIFQLLRKNPADRLSLSSVLDHAFMTGFSNVQSKVMGAVEDSMDSGHATISTGFTGSSGVSISGRFQEKRILSGPSLPNKVNIFQFKDKHPTERSNGGSFHNTQRENNDFSEGNGRKPVACEDRPHSRYLRRAHSSDRSGTSQSQTYAKPSSYSERCHSVEMLAKPTHLKGYRTSSPPNSYGDIPQMFTDERSLERHTSPPVKEKTPSEFMGPAKQTAPRSNDKAETVQQWFGAMQLNGQFKNTPDTSSVSNMGGDFYSQQATQNGAPQYAWNDVKRKKNTDSSIESVLLGIKKNPGTGQRKAEKSQFGEQSKSRVPQQAFGSSTLRSIISPLNAERLKPIRQKTKNAVVSILESGEVCMEFLKEQNSQERVKEVLRISCDGNLIYVYHPNEGKGFPLVDRPPSPPENRLSYTFDSLPEKYWKKYQYAAKFIKLVRSKTPKVTYYTRYAKCMLMENSPTADVEVCFYDGAKIHKTSDVIRVIEKSGRSYTLEGSRLSTLSDEVRSYLDHANESHCVCLSLESAINTEEKKGENISLFPITFGRRPALAESPKTQPTPSVDSARERKEEQSYVNRVLHGSAASPPQMPNLNPSLISYDGSVFSATTVQPSPTSNIHNTPDHAQVLKSVFVENVGWASQLNSGAVWVQFNDGSQLVVQPGVSSIIYTAPNGQITRHGENDKLPEYIKSKLQCLSSILMLFASSSSR UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.52651	Xl.56605
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PLK4
mouse		MGI	Plk4	All(4) Targeted, knock Out(1) Targeted, other(1) Chemically Induced(1) Gene Trapped(1)
zebrafish		ZFIN	plk4

Publications
First:		Polo-like kinases: a team in control of the division. [Cell Cycle 2006]
Most recent:		SmSak, the second Polo-like kinase of the helminth parasite Schistosoma mansoni: conserved and unexpected roles in meiosis. [PLoS One 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		3-phosphoinositide-dependent protein kinase activity AMP-activated protein kinase activity ATP binding More[+] DNA-dependent protein kinase activity G-protein coupled receptor kinase activity IkappaB kinase activity JUN kinase activity JUN kinase kinase activity JUN kinase kinase kinase activity Janus kinase activity MAP kinase 1 activity MAP kinase 2 activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP/ERK kinase kinase activity MP kinase activity NF-kappaB-inducing kinase activity SAP kinase activity atypical protein kinase C activity cGMP-dependent protein kinase activity calcium-dependent protein kinase C activity calmodulin-dependent protein kinase activity casein kinase I activity casein kinase activity cobinamide kinase activity cyclic nucleotide-dependent protein kinase activity cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein kinase activating kinase regulator activity cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity diacylglycerol-activated phospholipid-dependent protein kinase C activity elongation factor-2 kinase activity eukaryotic elongation factor-2 kinase activator activity eukaryotic elongation factor-2 kinase regulator activity eukaryotic translation initiation factor 2alpha kinase activity galactosyltransferase-associated kinase activity glycogen synthase kinase 3 activity multifunctional calcium- and calmodulin-regulated protein kinase activity non-membrane spanning protein tyrosine kinase activity phenol kinase activity phosphatidylinositol phosphate kinase activity phosphofructokinase activity phosphoinositide 3-kinase activity phosphorylase kinase activity phosphorylase kinase regulator activity phosphotransferase activity, alcohol group as acceptor protein binding protein kinase C activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein serine/threonine kinase activity receptor signaling protein tyrosine kinase activity ribosomal protein S6 kinase activity transmembrane receptor protein kinase activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:
EC:		Phosphotransferases with an Alcohol Group as Acceptor
KOG:		[D] Polo-like serine/threonine protein kinase

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.26957.1.A1_at [+] StrEns.568.1.S1_s_at StrEns.568.1.S1_at	Xl.7020.1.A1_at
Affymetrix 2.0			Xl2.7020.1.S1_at [+] Xl2.7020.1.S1_s_at

Symbol legend[+]