Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (80) GO Terms (12) Nucleotides (60) Proteins (33) Interactants (170) Wiki
XB-GENEPAGE-494160
Gene Symbol:
gja3

Gene Name:
gap junction protein alpha 3

Synonyms:
connexin 46 , cx46 , alpha3 connexin , Cx40.4 , connexin46 ( Add synonyms , Nomenclature history )

Gene Function:
connexon channel component

Protein Function :
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
cataract 2 multiple types [+]

OMIM:
CATARACT 14, MULTIPLE TYPES; CTRCT14

External Links:
 
Xenbase Gene ID XB-GENE-494161 XB-GENE-17347050 XB-GENE-17343444
Gene Symbol gja3 gja3.L gja3.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100135710
108707762
108709976
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein TrEMBL NCBI Protein NCBI Protein  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine gja3 gja3.L gja3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards GJA3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Gja3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Gja3 Ensembl
zebrafish
ZFIN, AGR gja3 ZFIN Ensembl
chicken
GEISHA GJA3 Ensembl
fruit fly
Publications
First Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes., J Cell Biol 1991  
Most Recent 4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation., Biochim Biophys Acta Mol Cell Biol Lipids 2020  
All View All Papers 1 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 5 terms 5 terms
PANTHER gja3
KEGG Pathways K07612 K07612 K07612
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks gja3
Clones Horizon Source BioScience Horizon Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info