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Summary Expression Gene Literature (5) GO Terms (37) Nucleotides (81) Proteins (32) Interactants (124) Wiki
XB-GENEPAGE-494613
Gene Symbol:
prkdc

Gene Name:
protein kinase, DNA-activated, catalytic subunit

Synonyms:
dna-pkcs , hyrc , p350 , dnapk , dnpk1 , hyrc1 , xrcc7 ( Add synonyms , Nomenclature history )

Gene Function:
DNA-dependent protein kinase

Protein Function :
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. M...[+]



Interactants:
Loading ...

Diseases: 


OMIM:
IMMUNODEFICIENCY 26 WITH OR WITHOUT NEUROLOGIC ABNORMALITIES; IMD26

External Links:
 
Xenbase Gene ID XB-GENE-494614 XB-GENE-866368 XB-GENE-17333764
Gene Symbol prkdc prkdc.L prkdc.S
Chromosome Chr06 chr6L
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 100488663
373602
mRNA NCBI Nucleotide RefSeq
Protein NCBI Protein RefSeq Swiss-Prot Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine prkdc prkdc.L prkdc.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PRKDC OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Prkdc MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Prkdc Ensembl
zebrafish
ZFIN, AGR prkdc ZFIN Ensembl
chicken
GEISHA PRKDC Ensembl
fruit fly
worm
Publications
First DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair., Proc Natl Acad Sci U S A 1995  
Most Recent Requirements for 5''dRP/AP lyase activity in Ku., Nucleic Acids Res 2014              
All View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 34 terms 7 terms 0 term
PANTHER prkdc
KEGG Pathways K06642
KOG [L] DNA-dependent protein kinase
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks prkdc
Clones Horizon Source BioScience Horizon Source BioScience

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