syt1 Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

XB-GENEPAGE-5752628

[provisional- machine annotated only]

Gene Symbol: syt1 [Predicted: Source is Human Entrez Gene]

Gene Name: synaptotagmin 1 [Predicted: Source is Human Entrez Gene]

Synonyms: syt, svp65 Add Xenopus synonyms

Gene Function: Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis

Interactants: cav2(3) , stx1a(3) , cacna1b(2) , cacna1c(2) , cacnb3(2) , cav1(2) , snap25(2) View All

XB-GENE-5752629

XB-GENE-6253875

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene	Entrez Gene
mRNA	NCBI Nucleotide >BC135176\|Xenopus tropicalis hypothetical protein LOC100037879, mRNA (cDNA clone IMAGE:7599553), partial cds CTCATTGATACAATCCAACTGGCTGTTCTAAGCAACTCAAAAGATAACTACTCACAAGGACCATCTATAAAGAGCAAGAGTCCTTCTCCAAAGGAGTTTACTGTGATAACAAGACTGCTTTAAGGTCTTTGGGGCCAACATGAAATTAAGTGAAAGTCGCCGGGAGGTGTTGGAAGAACTACAAACAACTGTAGCTGCACCTGCATTGCCGAACAATGCCACTGAAACCGTCGCACCTGGAGGAGGCAAAGATAATCACTTTTCTAAGCTGCGAGAAAAGTTCATGAATGAACTGAATAAAATTCCATTGCCACCATGGGCCTTAATAGCAATAGCCATAGTTGCAGTACTTCTCATTCTTACCTGCTGCTTTTGCGTCTGCAAGAAATGTTTATTCAAAAAGAAGAACAAGAAGAAGGGTAAAGAAAAGGGAGGAAAGAATGCTATTAATATGAAAGATGTAAAAGATTTAGGAAAGACAATGAAAGATCAGGATGATGATGATGATGCAGAAACTGGTTTGACTGATGGAGAAGACAAAGAGCAACCCAAAGAAGTGGAAAAGCTAGGGAAGCTTCAGTATTCACTGGATTATGATTTCCAAAACAATCAGCTGATGGTTGGGATAATTCAAGCTGCTGAGCTTCCTGCTTTAGATATGGGAGGTACTTCAGATCCATATGTGAAATTGTTCTTGATGCCAGATAAAAAGAAGAAATTTGAAACAAAGGTCCACAGAAAAACCCTTAATCCTGTCTTCAATGAACAGTTCACTTTCAAGGTGCCCTATGCTGAACTGGGAGGAAAAACATTGGTTTTGACAGTGTACGACTTTGATCGTTTTTCCAAGCATGACGTTATCGGGGATGTAAAAGTTCCCATGAACACAGTGGATTTTGGTCATGTGACTGAAGAATGGCGGGATTTAGTTAGTGCTGAAAAAGAAGAGCAAGAAAAACTGGGTGACATCTGCTTTTCCCTCCGCTACGTACCTACGGCTGGCAAGCTAACAGTTGTTATTCTCGAGGCAAAGAACCTAAAGAAGATGGATGTTGGTGGTTTATCAGATCCTTATGTGAAAATTCACCTAATGCAGAATGGCAAGAGACTGAAAAAAAAAAAAAAA	Refseq >NM_001094138\|Xenopus laevis synaptotagmin 1 (syt1), mRNA GTGTGCAGGTGTCAGGGAAACTGAATACATAAGATGAAGAATTTAGTATGTGATCACCTGGGAATCCTGCACCTCTCTATAGGGGGAAGGCACTAGAGGCTGATTCTCTGCAAACTGGGAGGGTAAATCCCTCATCTTTCCGGCGACAAACATGGTCGGGAAGGCGGCAAATACCACCGTGGCCACTACAATATACGCAGCAACCACCAAGGAGCCCGAATCCTGGATTGAAAGCATCTTGAATCGCATCCCATTGCCACGATGGGCCATATATGCTCTGGCTGGTGTGGCTCTATTCATCATCCTTCTCTTTATTATCTGCATTTGTTGTTGCTGCTGCAAAAGTAAGAAAAAAAAGAAGGAGAAAGGAAGAAAAATCGACGTGGGTAAAGTGCCGGGTGACATGACCTCGCAGCTGATACAGCCTGGAGCAGGGAACTCGGAGAAAGGAGAGAAGGTGGAATATCGGGGCCGTGTGCAGTACTCACTGGAATACAATTTCCAGACGGAGGAGCTCACAGTCAGCATTAAGCAGGCGGCTTCTCTAAAGGCGATGGACCTTGGGGGGACCTCTGACCCCTATGCCATAGTATACGTGTCCAATGATACTCGGAAAAAATATGAGACCAAAGTGAATCGCAAGACGCTGAATCCTGTGTTTAATGAGTCTTTCGTCTTCAAGGTAACACAAGAAGAGGTCTCAAGGACAACGGCTGTGGTACAGATCTATGATTTCAACCGCTTTTTAAAGCATGATGTGATCGGGGAGATGACCATACCACTGGGAGAAGTGAATCTACAGCATGTCTTAGAGGACTGGAAAGAACTGGGCCCTCCTGGGAAGACTGAGCATGAGCACTTGGGAGACATTTGCTTCTCTTTGAGATATGTCCCTAGTAATGGGAAACTCACAGTCATCATTCTAGAGGCAAAGAACCTTAAGAGAATGGATTCTGATGGATTTTCAGATCCATTTGTAAAAGTTCACCTGGCCCTAAACAGGAAAAAATGGAAACGGAAAAAGACAGCAGTGAAGCCTAGTACTCTGAAGCCATACTTTAATGAATCGTTTACATTTGATGTGTCACTGGAACAAATGAAGAATGTAGACCTAATCATATCTGTGTGGGATCATGACAAAGTGGGAAAGAATGAACAAATTGGAAAATTGTTTTTGGGGTGCCGAGCCTCAGGAAACGCTTTGAACCATTGGTCCGACATGCTGGCTCATCCCAGACGACCTATGGCACAATGGCACAAGCTACAGGAGGCACGGGAGGTGGACAAAATTCTTGACCTCAAAAGGAGCCTAAAACCATCTCTTCTCAGAAGCTTACCTTAATAAATTAATGTTTTGAAAGGCATCTTTACCATACATGCTGGATGCTTACTATAAAGACTGTATATGACTGGGAATGATGACAACAAAGCTGGGGAACATACAGTGTGTGATTCCATCAGTGAGAGCAGCTCAGGGAGATACTGGAGGAAAAAGCCCCCAAATCTGGTCTTCTGTGAGCCTCCCTTAGGTCTCTGCCTTAGCAAACTGAAGCTGGCCATACACAGGTAGATTTAAGATGCCAATTTGACCCCTTCAGACAAAGTCAGCAGCTTATTTCCCCATGTATGGGCCCTCCCTGATATATATCTATTATGCAGGTCTGAAAATTCCATCAAGGAAAGGACCAAATCAATGTGTTGATGGGAACTTGCATTGACCTCAATTATACATGATACAATTGTTGGCCTGGGGTCCAAATGATTCTATCAACCCGATTGGGCCCAGCACAAAGGTGTCCATATTGGGCAAAGATGTGCTCATTTCTAAAACCTCATCAAACGTGGATCTTCAAGTGTATGGCCAGCTTAAGAGATGGACGAGGATGCTCCAGTAAATATCAAGTCTAACGAAGCTACATTTGTCATTTTGCTGTTATCAAAGGAGATTACTGGGCAGTCTTGGCTTGCCCTTATTACACATTAATGAAATATTAGAAGAGTAGACATTAGTAATGTGTGATTTGGCATATAGGCAACCCAAGCCCAACCCTTACCTACTCACTGTCAACCCAGCCCCAGCATGACTAGATGTTCCCTCTTGATTTGTGAACTCACGTCAAAATGGCTCCATTCAGAGATGGGTGGAGTATTGCAGGCAAGTTGGTGGCAGAGTTGGGACAGGGACAGTGTCTCCAGAGCAGAGAGTTGGGTTTTAGCAGTTATGCCACTAAAGGAGCAATTTGAAGTCATAATAATGGCCAACCCTTGGTAAAACTGCATTTATTGGGCTGACTTGGGCACCACTAGTAGCAACAGTGCTGTCTAATGCTTCAGTGCTTTATTTCATGCAATTATTGCCAAGGGAATTGAACATCATTAAACATCATTATATCTACCCCATCTTTTAATTGCAATGCAATACATGCTACCTAAACAATATCTCCCATAACAACACATTAACTGATGTTCCACTTGTAGCAATGGTTTTGATTAAAGGATCCCCTATTGAGTTGGGGGAAGCAAAAAAGGGTTTACATCCCGTTTAGTTGTCTCTTTTACCCTTTATTCTCTTTTGTGAATCAAAAAGTAGCAGCTCACATCATGAACAGGAAAGAGCTGATGTGTTAATGTAGATGCCACAACCTCAGCAAACAAAGAGAGCAGCCTTGTGTTATTTAAATTATGATAAATCTGTGATTGTAAATGTTCTGTACGTTTGATTTTCCTTTCATTCTCCTGTATAATGTTAGATAAATAAATATACATTTGTGTGTTTATCTTTAAAAAAAAAAAAAAAAAAAAAA
Protein	NCBI Protein >AAI35177\|LOC100037879 protein [Xenopus (Silurana) tropicalis] MKLSESRREVLEELQTTVAAPALPNNATETVAPGGGKDNHFSKLREKFMNELNKIPLPPWALIAIAIVAVLLILTCCFCVCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQDDDDDAETGLTDGEDKEQPKEVEKLGKLQYSLDYDFQNNQLMVGIIQAAELPALDMGGTSDPYVKLFLMPDKKKKFETKVHRKTLNPVFNEQFTFKVPYAELGGKTLVLTVYDFDRFSKHDVIGDVKVPMNTVDFGHVTEEWRDLVSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKK	Refseq >NP_001087607\|synaptotagmin 1 [Xenopus laevis] MVGKAANTTVATTIYAATTKEPESWIESILNRIPLPRWAIYALAGVALFIILLFIICICCCCCKSKKKKKEKGRKIDVGKVPGDMTSQLIQPGAGNSEKGEKVEYRGRVQYSLEYNFQTEELTVSIKQAASLKAMDLGGTSDPYAIVYVSNDTRKKYETKVNRKTLNPVFNESFVFKVTQEEVSRTTAVVQIYDFNRFLKHDVIGEMTIPLGEVNLQHVLEDWKELGPPGKTEHEHLGDICFSLRYVPSNGKLTVIILEAKNLKRMDSDGFSDPFVKVHLALNRKKWKRKKTAVKPSTLKPYFNESFTFDVSLEQMKNVDLIISVWDHDKVGKNEQIGKLFLGCRASGNALNHWSDMLAHPRRPMAQWHKLQEAREVDKILDLKRSLKPSLLRSLP

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC	Xenbase

Synteny	Metazome

Expression	tropicalis	laevis
UniGene	Str.31619 [+] Str.54740	Xl.52686
Unigene EST Profile	EST Profile	EST Profile
GEO data		GEO
Images	0 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	SYT1
mouse	MGI	Syt1	All(9) Targeted, knock Out(1) Targeted, other(8)
zebrafish	ZFIN ZFIN	syt1b syt1a

Publications
First:		The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type). [J Biol Chem 2003]
Most recent:		Extended-Synaptotagmin-2 Mediates FGF Receptor Endocytosis and ERK Activation In Vivo. [Dev Cell 2010]
		View All Papers

Functional Ontologies
GO: Molecular:		transporter activity
Biological:		transport
Cellular Component:		membrane synaptic vesicle
EC:
KOG:		[TU] Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis

Reagents	tropicalis	laevis
Clones	open biosystems	open biosystems
	geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0	Str.31619.1.S1_at [+] Str.49192.1.S1_at
Affymetrix 2.0		Xl2.39779.1.S1_at [+] Xl2.52686.1.S1_at

Symbol legend[+]