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Summary Expression Gene Literature (3) GO Terms (24) Nucleotides (74) Proteins (30) Interactants (31) Wiki
XB-GENEPAGE-5755295
Gene Symbol:
chrna5

Gene Name:
cholinergic receptor nicotinic alpha 5 subunit

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
acetylcholine receptor

Protein Function :
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.



Interactants:
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Diseases: 


OMIM:
SMOKING AS A QUANTITATIVE TRAIT LOCUS 3; SQTL3

External Links:
 
Xenbase Gene ID XB-GENE-5755296 XB-GENE-5755312 XB-GENE-17336685
Gene Symbol chrna5 chrna5.L chrna5.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100379824
446384
108712962
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. NCBI Protein RefSeq  More.. NCBI Protein
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine chrna5 chrna5.L chrna5.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CHRNA5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Chrna5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Chrna5 Ensembl
zebrafish
ZFIN, AGR chrna5 ZFIN Ensembl
chicken
GEISHA CHRNA5 Ensembl
fruit fly
worm
Publications
First Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula., Neuron 2011  
Most Recent The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2* and α3β4* Receptors., Front Synaptic Neurosci 2020  
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 23 terms 6 terms 0 term
PANTHER chrna5
KEGG Pathways K04807 K04807
KOG [T] Acetylcholine receptor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks chrna5
ORFs chrna5.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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