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Summary Expression Gene Literature (6) GO Terms (56) Nucleotides (161) Proteins (44) Interactants (1825) Wiki
XB-GENEPAGE-5768571
Gene Symbol:
lrrk2

Gene Name:
leucine-rich repeat kinase 2

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
tyrosine kinase

Protein Function :


InterPro :
Tetraspanin/Peripherin , Tetraspanin , Tetraspanin EC2 sf , DNA/RNA-bd Est1-type [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
autosomal dominant Parkinson disease 8 [+]

OMIM:
PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8

External Links:
 
Xenbase Gene ID XB-GENE-5768572 XB-GENE-6252262 XB-GENE-17342223
Gene Symbol lrrk2 lrrk2.L lrrk2.S
Chromosome Chr3 chr3L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2
CDS Gene model Gene model
Entrez Gene 100145062
445832
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. NCBI Protein NCBI Protein  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine lrrk2 lrrk2.L lrrk2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards LRRK2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Lrrk2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Lrrk2 Ensembl
zebrafish
ZFIN, AGR lrrk2 ZFIN Ensembl
chicken
GEISHA LRRK2 Ensembl
fruit fly
worm
Publications
First A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway., Mol Neurodegener 2017    
Most Recent A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway., Mol Neurodegener 2017    
All View All Papers 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 54 terms 7 terms 0 term
PANTHER lrrk2
KEGG Pathways K08844 K08844
KOG [T] Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks lrrk2
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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