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Summary Expression Gene Literature (143) GO Terms (11) Nucleotides (532) Proteins (52) Interactants (306) Wiki
XB-GENEPAGE-5810263
Gene Symbol:
tpx2

Gene Name:
TPX2, microtubule-associated

Synonyms:
dil2 , dil-2 , hctp4 , repp86 , tpx2-a , tpx2-b ( Add synonyms , Nomenclature history )

Gene Function:
Immunoglobin and related proteins

Protein Function :
Spindle assembly factor. Required for normal assembly of mitotic spindles. Mediates the binding kif15 and aurka to spindle microtubules. Required for targeting kif15 to microtubule minus ends. Activate...[+]



Interactants:
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Diseases: 


Disease Ontology:
prostate cancer

OMIM:
PROSTATE CANCER

External Links:
1/3
 
Xenbase Gene ID XB-GENE-5810264 XB-GENE-6251919 XB-GENE-6255926
Gene Symbol tpx2 tpx2.L tpx2.S
Chromosome scaffold_4312 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100124787
398174
446586
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine tpx2 tpx2.L tpx2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards TPX2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Tpx2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Tpx2 Ensembl
zebrafish
ZFIN, AGR tpx2 ZFIN Ensembl
chicken
GEISHA TPX2 Ensembl
fruit fly
worm
Publications
First Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein., J Cell Biol 1998                  
Most Recent The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation., Cell Commun Signal 2020                
All View All Papers 2 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 9 terms 8 terms
PANTHER tpx2
KEGG Pathways K16812 K16812 K16812
KOG [RP] FOG: Immunoglobin and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tpx2
Morpholinos tpx2 MO1 tpx2 MO1 tpx2 MO1
ORFs tpx2 ORF1 tpx2.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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