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Summary Expression Gene Literature (18) GO Terms (22) Nucleotides (88) Proteins (26) Interactants (113) Wiki
XB-GENEPAGE-5828963
Gene Symbol:
dna2

Gene Name:
DNA replication helicase/nuclease 2

Synonyms:
xdna2 ( Add synonyms , Nomenclature history )

Gene Function:
DNA replication helicase

Protein Function :
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucle...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
Seckel syndrome 8

OMIM:
PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL [+]

External Links:
 
Xenbase Gene ID XB-GENE-5828964 XB-GENE-17338476 XB-GENE-5829000
Gene Symbol dna2 dna2.L dna2.S
Chromosome Chr7 chr7S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 100170166
378492
mRNA NCBI Nucleotide RefSeq
Protein NCBI Protein RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine dna2 dna2.L dna2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards DNA2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Dna2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Dna2 Ensembl
zebrafish
ZFIN, AGR dna2 ZFIN Ensembl
chicken
GEISHA DNA2 Ensembl
fruit fly
worm
Publications
First Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex., Nature 1994  
Most Recent HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome., Proc Natl Acad Sci U S A 2018                                  
All View All Papers 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 4 terms 0 term 22 terms
PANTHER dna2
KEGG Pathways K10742 K10742
KOG [L] DNA replication helicase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks dna2
Antibodies Dna2 Ab1 Dna2 Ab1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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