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Summary Expression Gene Literature (3) GO Terms (11) Nucleotides (265) Proteins (36) Interactants (62) Wiki
XB-GENEPAGE-5840592
Gene Symbol: hmgcr

Gene Name: 3-hydroxy-3-methylglutaryl-CoA reductase

Synonyms: ( Add synonyms , Nomenclature history )

Gene Function: 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase

Protein Function :
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.

Interactants: Loading ...
OMIM Diseases: 3-HYDROXY-3-METHYLGLUTARYL-CoA REDUCTASE; HMGCR

 
Xenbase Gene ID XB-GENE-5840593 XB-GENE-5840728 XB-GENE-17334952
Gene Symbol hmgcr hmgcr.L hmgcr.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene: 100380121
Entrez Gene: 397750
Entrez Gene: 108707262
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein TrEMBL RefSeq Swiss-Prot NCBI Protein TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine hmgcr hmgcr.L hmgcr.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
HMGCR OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Hmgcr MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR hmgcra hmgcrb ZFIN Ensembl
chicken
GEISHA HMGCR Ensembl
fruit fly
FLYBASE Hmgcr Ensembl
worm
WORMBASE
Publications
First Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions., Biochem Pharmacol 2007  
Most Recent Metabolic and immune impairments induced by the endocrine disruptors benzo[a]pyrene and triclosan in Xenopus tropicalis., Chemosphere 2016  
All View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 10 terms 7 terms 6 terms
PANTHER hmgcr
KEGG Pathways K00021
KOG [I] 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon
ORF hmgcr.L ORF1
Affymetrix 1.0 Str.16151.1.S1_at [+] Xl.5016.1.A1_at [+]
Affymetrix 2.0 Xl2.800.1.S2_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.12.1


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