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Summary Expression Gene Literature (3) GO Terms (13) Nucleotides (282) Proteins (41) Interactants (65) Wiki
XB-GENEPAGE-5840592
Gene Symbol:
hmgcr

Gene Name:
3-hydroxy-3-methylglutaryl-CoA reductase

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase

Protein Function :
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.



Interactants:
Loading ...

Diseases: 


OMIM:
3-HYDROXY-3-METHYLGLUTARYL-CoA REDUCTASE; HMGCR

External Links:
 
Xenbase Gene ID XB-GENE-5840593 XB-GENE-5840728 XB-GENE-17334952
Gene Symbol hmgcr hmgcr.L hmgcr.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100380121
397750
108707262
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein RefSeq Swiss-Prot NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine hmgcr hmgcr.L hmgcr.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, HMGCR Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Hmgcr MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Hmgcr Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR hmgcra hmgcrb ZFIN Ensembl
chicken
GEISHA HMGCR Ensembl
fruit fly
FLYBASE Hmgcr Ensembl
worm
Publications
First Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions., Biochem Pharmacol 2007  
Most Recent Metabolic and immune impairments induced by the endocrine disruptors benzo[a]pyrene and triclosan in Xenopus tropicalis., Chemosphere 2016  
All View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 12 terms 7 terms 6 terms
PANTHER hmgcr
KEGG Pathways K00021 K00021
KOG [I] 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks hmgcr
ORFs hmgcr.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon

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