pkn1 Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

XB-GENEPAGE-5859254

[provisional- machine annotated only]

Gene Symbol: pkn1 [Predicted: Source is Human Entrez Gene]

Gene Name: protein kinase N1 [Predicted: Source is Human Entrez Gene]

Synonyms: dbk, pkn-alpha, pkn, pak1, prk1, pak-1, prkcl1 Add Xenopus synonyms

Gene Function: Serine/threonine protein kinase

Interactants: pak1(15) , cdc42(6) , cdkn1a(6) , rac1(6) , rho(5) , cdk1(3) , nck1(3) View All

XB-GENE-5859255

XB-GENE-6487324

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene
mRNA	NCBI Nucleotide >XM_002935406\|PREDICTED: Xenopus (Silurana) tropicalis protein kinase N1 (pkn1), mRNA GTGTGTGTCGCACCATGCCGCATACTCCGCTTGGGCCAGGGCCGCAGGATGGAGAGGTACAGGTTAACAATTGCACTCCCTGCATATTGAGAGAGGAGAGCAGGGGGGAAAGAAGAGAGGCACAATCAGGAGACAGACAACCGGGGGAAGTCCAAGAGACGTGTCCAAGTGATGGCATGGAAACACAAAGAGACAGCAAGAAGGTTAAACAAGGGGACTCTTTAGAGGAAACAGAGGGACTTGAGAGAGGAGACCAGCAGGGGATGGAGGGAGAGAGGGGGGAAACACATGGGTTTGAAGGAGAGAGAGATCGACTCCGCAAGGAGATTAGTAGGGAGCTGAAGATAAAGGAAGGTGCGGAAAAGCTTCGAAGAGCCACCACGGAGCGCAAGAACCTGGGACATGTAGAAACCATGCTACGGACATGTGAAAAGAGACTGGAGAGCTTAAAACAGGAACTGGATGATTTAGAGACCACTCCTACTTCTCCAGTATCTACTGGAGCCGACCCCCACTCTCCAGGTCTGCGCACTGATGGACAGAGATCTAAGATCTTGGGCCTAGAGCGACAGTTAGACATTGAGTTGCGAATGAGAAAAGGAGCAGAGAATATGTTGCAGATGTACAGCCAAGGAGGAGCCAAGGACAAGAAACTACATTCAGCCACCCATCAGATGTTATCCGAGAGTGATATAAAAATCCGCTTCCTTCGTGCACAGATCTACAAGGAGAGCCAGGACACCTCTGGTGCAGGGGAAGGTGCCCTTGAGGTGCTACACAATGAACTGCGCATTGAGGAAGCAAGGCATCACTACCGGGTGGAGCGAGCCGTGGCTGAGGGAGCCGAGAATGCTCTAAGAATGCTGGGAGCTGCAAGAACTCAGGACAGGAGTGCAATCAATGAGGTCCAAGCTCGTCTGTTGGAGTCTCAGCAGAGGACAGACCTGCTAGCGCTCTCACTCCAGAGGTGCCTCGATGAATTACCACATGATCACCCCAAGAGATGTATCTTGCGAGAGGAGCTGGCTCTGCACAGTTCTCCCTCCAGACTTGATGCCTCCTCTCTCCTAACTCCCTACAGTAGTGTCTCCAAGCCCGCTCCTCTCACAGGTGTCTTAGAGGTTTGTATTGTGGATTGCACTAAAATCCTAGACATGGTGCCTGGAAGAACACGAGCCTCCCCTACCCGGTTACCAAACAACGTCAGCCCCTTAGAAGGCCTTGCCATGAGAACACGGACTGGGCGGAACATGTACTCACGCACAGCCAGTCTGAGTCGCAGTGAGGAACTGTCAGATGAGATCAGTGTCGTGCTGAGACTGGATAACAATGTGGTTGGACAGACTGCCTGGAAGTCTGAGGGACGAGACACATGGGATCAGATATTCAAACTGAAGCTGGAGAGGGCTCGAGAGCTGCAGCTGTCCGTGTACAGGAGAGACTACCGCTCACTCTGTGCTATTAAATACCTCAAGTTAGAAGATTTCCTGGATCATCAAAAGCATGAAACATACCTGGAACTGGAACCCCAGGGGACCTTGTTGTGTGAGGTGGCATTCTACAACCCAGTGATTGAAAGATTCTCCAACCTGCGCCGACAGAAAAAGATCTTCTCCAAGGAACAAGGAAGGGCGTTTCTTCGTGCACGACAGATGAATATTGACCCATTAACATGGCTCCGCCTGTTGCGCCGAGGAGTTAATACCAGCAGTGTGGTCTACAGCCCTGGAGATCGAGGAGCCGAGTTGCAGTTGGAATCCCTTACCCTAGAGACAAAGGAAGAAATTAAGAATGAGGTTCCTGTCCCAGAGGAAAAGCAAGTCCCAGTAGTAAGAAGAGAAAGCCAAAGGAGAACGCAGAGTGTCTCTCAGCTTTCCTTAGACAATTTCCGGCTGTTGGCGGTGCTGGGCAGGGGTCACTTTGGGAAGGTCCTGCTGTCTGAGTACAAGGAGACTGGGGAATTGTTTGCCATCAAAGCCTTGAAGAAAGGGGACATCATTTCTAGGGATGAAGTAGAGAGCCTTCTGTGTGAGAAGCGCGTGTTTGTTGCAGTAAGTGCTGCCTCACACCCGTTCCTGCTTAGCCTCCTGGGATGTTTCCAGACTGCGGATGATGTACACTATGTCAGTGTAATGCCTATACATATATATATATATTCTTACCCTTTACATGTGCTTTTCTTCAGGTTCTACGCTGCCTGTGTCCTTTTGGGCTTACAGTTTCTGCACAGCAAGAACATTGTGTACAGGGATCTCAAGCTGGATAATCTACTGCTGGATTCAGAAGGATATGTGAAACTCGCTGATTATGGTCTCTGCAAAGAGGGTATGGGCCCATCTGACCGCACCTCCACATTCTGTGGCACGCCAGAGTTCCTTGCCCCAGAGGTCCTCACAGATGCCTCTTACACTCGAGCTGTCGACTGGTGGGGATTTGGGGTCCTGATCTATGAGATGATGGTTGGAGAGTCTCCATTCCCAGGTGATGAGGAGGAGGAAGTGTTTGACAGCATTGTTAACGATGAAGTTCGTTACCCACGTTTCCTCTCTGCCGAAGCTATTGCCGTCATGAGACGGCTCCTGCGCAGGAATCCTGAAAGACGGTTAGGATCAGGGGAAAGAGACGCTGAAGATGTGAAAAAACAGCCATTTTTCAAGGAAATGGATTTTGAAGCCCTCCTCTCCCGTCGATTGCCACCTCCTTTTACCCCATGTGTGAAGGGGCCACACGACATCAGTAACTTTGACCCCGAATTCACATGTGAGGGGCCAGAACTGACTCCTCCACGGGAGCCTCGACTTCTGAAGCCTGAGGAGCAAGAATTGTTCCACGGATTTGACTATGTGCGGGAGGGAGCGTAAGGGGGTAGAGCTGATAAGTGGGTGCAGTTCTTTCTGTTTTTCCTTTCCCCTTCTCATGTTTTCTGTGTCATTCTCTAGCTCAAGCTGTGGGTCAGATATGTCTAATAGATAAATGTAGCCTTGGCTTGCCCACAGATTCCACTGACTTTCTGTAAAACCTAATGATTTTATTTTAATCCAGCCCCCAAATATGAAGTCTTGTGGATAATTGGCCGAGTACCTGAAAGTTGGATATGGATTCTCCTTTCCTTTATTGACTCTTCCAGCCCCTCTGTCCCTTCTGCTCCTCTGCGCTCTCTCAGGGAAAGCCATGTAAATAAAATTGTTTTGTAACATTTTA
Protein	NCBI Protein >XP_002935452\|PREDICTED: serine/threonine-protein kinase N2 [Xenopus (Silurana) tropicalis] MPHTPLGPGPQDGEVQVNNCTPCILREESRGERREAQSGDRQPGEVQETCPSDGMETQRDSKKVKQGDSLEETEGLERGDQQGMEGERGETHGFEGERDRLRKEISRELKIKEGAEKLRRATTERKNLGHVETMLRTCEKRLESLKQELDDLETTPTSPVSTGADPHSPGLRTDGQRSKILGLERQLDIELRMRKGAENMLQMYSQGGAKDKKLHSATHQMLSESDIKIRFLRAQIYKESQDTSGAGEGALEVLHNELRIEEARHHYRVERAVAEGAENALRMLGAARTQDRSAINEVQARLLESQQRTDLLALSLQRCLDELPHDHPKRCILREELALHSSPSRLDASSLLTPYSSVSKPAPLTGVLEVCIVDCTKILDMVPGRTRASPTRLPNNVSPLEGLAMRTRTGRNMYSRTASLSRSEELSDEISVVLRLDNNVVGQTAWKSEGRDTWDQIFKLKLERARELQLSVYRRDYRSLCAIKYLKLEDFLDHQKHETYLELEPQGTLLCEVAFYNPVIERFSNLRRQKKIFSKEQGRAFLRARQMNIDPLTWLRLLRRGVNTSSVVYSPGDRGAELQLESLTLETKEEIKNEVPVPEEKQVPVVRRESQRRTQSVSQLSLDNFRLLAVLGRGHFGKVLLSEYKETGELFAIKALKKGDIISRDEVESLLCEKRVFVAVSAASHPFLLSLLGCFQTADDVHYVSVMPIHIYIYSYPLHVLFFRFYAACVLLGLQFLHSKNIVYRDLKLDNLLLDSEGYVKLADYGLCKEGMGPSDRTSTFCGTPEFLAPEVLTDASYTRAVDWWGFGVLIYEMMVGESPFPGDEEEEVFDSIVNDEVRYPRFLSAEAIAVMRRLLRRNPERRLGSGERDAEDVKKQPFFKEMDFEALLSRRLPPPFTPCVKGPHDISNFDPEFTCEGPELTPPREPRLLKPEEQELFHGFDYVREGA

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC

Synteny	Metazome

Expression	tropicalis	laevis
UniGene	Str.52620 [+] Str.63151	Xl.51595 [+] Xl.73544
Unigene EST Profile	EST Profile	EST Profile
GEO data		GEO
Images	0 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	PKN1
mouse	MGI	Pkn1	All(2) Targeted, other(1)
zebrafish

Publications
First:		Xenopus PKN: cloning and sequencing of the cDNA and identification of conserved domains. [Biochim Biophys Acta 1995]
Most recent:		Activity of the RhoU/Wrch1 GTPase is critical for cranial neural crest cell migration. [Dev Biol 2011]
		View All Papers

Functional Ontologies
GO: Molecular:		3-phosphoinositide-dependent protein kinase activity AMP-activated protein kinase activity ATP binding More[+] DNA-dependent protein kinase activity G-protein coupled receptor kinase activity IkappaB kinase activity JUN kinase activity JUN kinase kinase activity JUN kinase kinase kinase activity Janus kinase activity MAP kinase 1 activity MAP kinase 2 activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP/ERK kinase kinase activity MP kinase activity NF-kappaB-inducing kinase activity SAP kinase activity atypical protein kinase C activity cGMP-dependent protein kinase activity calcium-dependent protein kinase C activity calmodulin-dependent protein kinase activity casein kinase I activity casein kinase activity cobinamide kinase activity cyclic nucleotide-dependent protein kinase activity cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein kinase activating kinase regulator activity cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity diacylglycerol-activated phospholipid-dependent protein kinase C activity elongation factor-2 kinase activity eukaryotic elongation factor-2 kinase activator activity eukaryotic elongation factor-2 kinase regulator activity eukaryotic translation initiation factor 2alpha kinase activity galactosyltransferase-associated kinase activity glycogen synthase kinase 3 activity multifunctional calcium- and calmodulin-regulated protein kinase activity non-membrane spanning protein tyrosine kinase activity phenol kinase activity phosphatidylinositol phosphate kinase activity phosphofructokinase activity phosphoinositide 3-kinase activity phosphorylase kinase activity phosphorylase kinase regulator activity phosphotransferase activity, alcohol group as acceptor protein kinase C activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein serine/threonine kinase activity receptor signaling protein tyrosine kinase activity ribosomal protein S6 kinase activity transmembrane receptor protein kinase activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation signal transduction
Cellular Component:		intracellular
EC:		Phosphotransferases with an Alcohol Group as Acceptor
KOG:		[T] Serine/threonine protein kinase (alt_id KOG:0694)

Reagents	tropicalis	laevis
Clones	open biosystems	open biosystems
	geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0	Str.32052.1.S1_at	Xl.13023.1.A1_at
Affymetrix 2.0		Xl2.13023.1.A1_at [+] Xl2.51595.1.S1_at

Symbol legend[+]