Gene Symbol: gtf2h4 [provisional] Gene Name: general transcription factor IIH, polypeptide 4, 52kDa [provisional] Synonyms: tfb2, tfiih Add Xenopus synonyms Gene Function: transcriptional regulator Interactants: cdk7(3) , cdk1(2) , pold1(2) , anxa2(1) , ccnb1.2(1) , cdk2(1) , cdkn1a(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001015845|Xenopus (Silurana) tropicalis general transcription factor IIH, polypeptide 4, 52kDa (gtf2h4), mRNA CTTAGTTGCCCGGCAGGAGCCGAGGACCTGGGACATGTAAGCGGTGTTGGGCACATTTAAACAGCCACAGTGACAAGGAAATTGGCCCTGTAAGCGGTCTGCTAACATGAAATTCCTATGCCATCCTTAGAGAAACAAGAAGAATGTCTCTGATGAATGAGAATATCACCTAACCAATGAAACACTTGGTACCATTTTTGATGTTGATTGCACGATACAGACTGTAGTGGCCCTAACAAAAAGACTTCTGTGGAATGAAGCTCCAGCGGGTACAGCTGAAGTGTAAGAATTTGCATGAGTTTCTTCAGGAACTCAGCCCAGGGGTGCTCGATCAATTGTACAACCATCCAGCAACATGTTTGGCTGTGTTCAGGGAACTCCCAGGACTGGCCAAAAATTATGTGATGCGTATGCTATTTCTGGAACAACCCTTGCCTCAAGCTGCGGTTGCATTATGGGTTAAGAAGGAAAATTTCAAGGAGCATGAGGAGAATACACAAGTCCTGACTGGGTTACGGCTTTGGCACACACAGCAGCTTCCTGGTGGGCTACAGGGTCTGATTCTCAATCCAATCTTTAGAGAAAATCTTAAAATAGCTCTGCTAGGCGGGGGAAAACCTTGGGCAGATGATGGTTGCCTACTAGGCCCTGATAAACATGGAAAAGATGTGGTCTCGTTGGATAAGTATGCAGAAGAGAGATGGGAGGTTATTTTACATTTTATGGTTGGGTCTCCAAGTGCTGCTGTTAGCCAGGACTTGGCACAACTGCTTATACAGGCCGGCCTTATGAAAAGTGAGTCTGGGGAAGCCCCCTGTATTTCATCAGCTGGCTTCCAATTTTTGCTTTTGGACACACCTTCTCAGCTCTGGTATTTTATGCTTCAATATCTCAAATCCGCAGAGTCTCGTGGGATGATTCTGGTGGAAATACTCTCCTTCATGTTCCAGTTAAGCTTCTCAACATTGGGAAAGGATTACTCTGTGGAAGGGATGAGTGATTCCTTACTTACTTTTCTTCAACACTTGCGTGAATTCGGCCTTGTGTTTCAAAGAAAGAGAAAGTCCCGCCGTTACTATCCAACACGTCTGGCTATAAACCTCGCATCTGGAATATCTGGATCAGTTGTTGACAGCCATAAGCAAGGGTTTATTGTTGTGGAAACAAACTACAGAATATATGCATACACAGATTCAGAGCTGCAGATTGCTCTGATTGCCCTGTTTTCTGAAATGCTGTATCGTTTCCCAAACCTGGTTGTGGCACAGGTCACTCGAGAGAATGTACAGCAAGCTATAGGAAATGGCATCACCGCTGAGCAGATAATTCATTTTCTGAGGACAAGAGCACATCCAGTGATGTTGCAGCAGAACCCAGTGCTTCCACCAACAATTACTGACCAAATTCGACTGTGGGAACTGGAGAGAGACCGTCTACGTTTCTCTGAAGGTGTCCTGTACAACCAGTTTTTATCCCAAGTGGACTTTGAACTTTTGAGAAATTATGCACGAGACCTTGGAGTGTTGGTGTTTGAGAATCCAGCCAAGCGTGTGATGGTGGTGACACCTGGAGGACATTCTGATGTTAAGCGCTTCTGGAAACGCCAAAAGCACAGCTCCTAAGCTACATGTCATGGTCACTCTGGGTGAAATAGAAACAACTGTAACTTTTATATGGGGTCTTCCAGTTTTGTGACAAAAAAACTAATATTTACTATCATTTGCTGCTAGGGAACACCCTCAATGTGATAATCTTTTCATCATCAAAGGGGTTTTGTTCCCAAATCTTGCTTTTTAGGGTCCTAGGATTTGAAAGGGTTATAATGATGGCTGCCGTGTGTTATGAAAGACTGTAAAATCACTTCCTTAGACACCAGATAAAGCAAGTTATATGTCCTTATTGTCTTCAGTGTTACTACTGTGTGGCAATAAGAAACTTTCCTCCATCTGTAAATTGTGAATTGAGAAAGAGGGTATTTTCCATACAGTGCAGATGTTTACGTTAGACCCCTGAAAACAATACCCAGCTTATATTAGCTTGGCCAGTTTGAACCATGCTATCCAAACAGCTGTCATGTTTGACACCTCCAAGGTTCAGTTTCAACAGACCACCCTAAAGTCCTGTCGCATCACAGTCCCAACAAATTGAAAATAATATCTGCCTCCGCTTGTCAGGTGGATGGTGAATTGGAAGCTGCAGAAGTGAGAGGAACTACATCTCCTTCATACTTTTTCACCATTATTCATGATTGACATTATTTTAATATAATCTGCCCTGCAAAAACACTGTAGGAGACATAATCGGTCCATGAAATATAACAAATTGGACAGCACTGCCCCAACTATGTTTTGCTGAATTAGTATAATTAAGTTCATTGTACAGATTTAAATGCACTGTTATTCTAATACAACGAAAAAGGTTTTTCATGAAGAATCTTTTTGCTTTTCCGTTTTGCACATCAGTAAATCTAGAGAGCTGTTCAAATATATGAAAGTTGATGCTAAAAAGGTTTTGTAATAAAGAATCTCCACTATATAACAGTGAACATTATAAGTAATAAAGATAAATAAAATAATTACCTAGATTGTTTTCCTTGTTAGATGGAAGAAATACTCTGGTTAATCGACCGTTTGGTGTGATCCTACCAGTAAATGGGCAAAATGGAAAAAACAGGCCCAATTATGACCCTATTTAGAGTGTGTAGCAGTAAAGGGTGCATAATCATCATTTTCAGCAGCCAATCAGCAGCTGAATTGTTTCAGCGTCAGAACTGAAGGAAGTAGCAAAGGACAAACAGAACCTGCTTATGATGATTATAAATACTTTTATTACAAATGTTTAATGATTTTGTAAAGTTGCTTACAATTAAAACTGATTTCATAAAGCAAAAAAAAAAAAAAAAAAAAAAAAAACAAAAAAAAAAAAAAAA	Refseq >NM_001091641|Xenopus laevis general transcription factor IIH, polypeptide 4, 52kDa (gtf2h4), mRNA GCGGTGTTGCAGCGCGTTTAAACAACGAGTCGGGACTGCGGGTTGTGGGCAGTGTTAAGAAACTCGGTCTGCTAACATGGAATTCCAATGCCATCCTTGGAGAAACAAGAATCTCACCGATGAATGAGAATATCACTTAACTGATGAGACATTGGACGCCTCTTTACTTTTGGTTTTGAGTGCATTACAAACCCTATCGGGCCTAACAGAAAGAAAAAAGGTCAGTAAAATGAAGCTCCAGCGAGTACATCTGAAGTGTAAGAATTTGCACGAGTTTCTTCAGGAACTCAGCCCAGGGGTGCTCGATCGATTGTACAACCATCCAGCAACTTGTTTGGCTGTGTTCAGGGAACTCCCAGGATTGGCCAAAAATTATGTGATGCGTATGCTATTTCTGGAACAACCCTTGCCTCAAGCTGCTGTTGCATTATGGGTCAAGAAGGAAAATTTCAATGAACATGAGGAGAATACACAGGTCCTGACTGGGTTACGACTTTGGCACACACAACAACTCCCTGGTGGGTTACAGGGCCTGATTCTCAATCCAATCTTTAGAGAAAATCTTAAAATAGCACTGCTAGGCGGGGGAAAAGCTTGGGCAGATGATGGCTGCCTACTAGGCCCTGATAAACATGGAAAAGATGTGGTCTCGTTGGATAAGTATGCAGAAGAGAGATGGGAGGTCATATTACATTTTATGGTTGGGTCTCCAAGTGCTGCTGTTAGCCAGGACTTGGCACAACTGCTTATACAGGCTGGCCTTATGAAAAATGAGTCTGGGGAAGCTCCTTGTATTTCATCAGCTGGCTTCCAGTTTTTGCTTTTGGACACACCTTCTCAGCTCTGGTATTTTATGCTTCAGTATCTCAAATCTGCAGAGTCTCGTGGAATGAATCTTGTGGAAATACTCTCCTTCATGTTCCAGTTAAGCTTCTCTACTTTGGGAAAGGATTACTCTGTGGAAGGGATGAGTGATTCCTTACTGACATTTCTACAACACCTACGTGAATTTGGCCTTGTGTTTCAAAGAAAGAGAAAGTCACGTCGATACTATCCAACACGTCTGGCTATAAACCTTGCATCTGGTATATCTGGCTCGGTTGTTGACAGCCATAAGCAAGGGTTTATTGTTGTGGAAACAAACTACAGAATATATGCATACACAGATTCAGAGCTGCAAATTGCCCTTATTGCCCTGTTCTCTGAGATGTTGTATCGCTTCCCAAATCTGGTTGTGGCACAAGTCACTCGAGAGAATGTCCAGCAAGCGATAGGGAATGGCATCACTGCTGAGCAGATAATCCACTTTCTGAGGACAAGAGCACATCCAGTGATGTTGCAGCAGAATCCAGCGCTTCCACCAACAATTACTGACCAAATAAGACTTTGGGAACTCGAGAGAGACCGCCTACGTTTTTCTGAAGGTGTCCTGTACAACCAGTTTCTATCCCAAGTGGACTTTGAACTTTTGAGAAACTATGCACGTGATCTTGGAGTGCTCGTGTTTGAGAATCCAGCCAAGCGTGTGATGGTAGTGACCCCCGGAGGACACTCTGATGTTAAGCGTTTCTGGAAACGCCAAAAGCAAAGCTCCTGAGGTTTACATGTGATGGTCACCACTAATTCTGGATAAACTAGAAGCAACTGAAACTTTAATATATGGGACCTTTTGTCCTCCAAATGCGACAGTCTTTTAATCATTAAAAGAGGTCATTTTCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAAAAAAAAAAAAAAA
Protein		Refseq >NP_001015845|general transcription factor IIH, polypeptide 4, 52kDa [Xenopus (Silurana) tropicalis] MKLQRVQLKCKNLHEFLQELSPGVLDQLYNHPATCLAVFRELPGLAKNYVMRMLFLEQPLPQAAVALWVKKENFKEHEENTQVLTGLRLWHTQQLPGGLQGLILNPIFRENLKIALLGGGKPWADDGCLLGPDKHGKDVVSLDKYAEERWEVILHFMVGSPSAAVSQDLAQLLIQAGLMKSESGEAPCISSAGFQFLLLDTPSQLWYFMLQYLKSAESRGMILVEILSFMFQLSFSTLGKDYSVEGMSDSLLTFLQHLREFGLVFQRKRKSRRYYPTRLAINLASGISGSVVDSHKQGFIVVETNYRIYAYTDSELQIALIALFSEMLYRFPNLVVAQVTRENVQQAIGNGITAEQIIHFLRTRAHPVMLQQNPVLPPTITDQIRLWELERDRLRFSEGVLYNQFLSQVDFELLRNYARDLGVLVFENPAKRVMVVTPGGHSDVKRFWKRQKHSS	Refseq >NP_001085110|general transcription factor IIH, polypeptide 4, 52kDa [Xenopus laevis] MKLQRVHLKCKNLHEFLQELSPGVLDRLYNHPATCLAVFRELPGLAKNYVMRMLFLEQPLPQAAVALWVKKENFNEHEENTQVLTGLRLWHTQQLPGGLQGLILNPIFRENLKIALLGGGKAWADDGCLLGPDKHGKDVVSLDKYAEERWEVILHFMVGSPSAAVSQDLAQLLIQAGLMKNESGEAPCISSAGFQFLLLDTPSQLWYFMLQYLKSAESRGMNLVEILSFMFQLSFSTLGKDYSVEGMSDSLLTFLQHLREFGLVFQRKRKSRRYYPTRLAINLASGISGSVVDSHKQGFIVVETNYRIYAYTDSELQIALIALFSEMLYRFPNLVVAQVTRENVQQAIGNGITAEQIIHFLRTRAHPVMLQQNPALPPTITDQIRLWELERDRLRFSEGVLYNQFLSQVDFELLRNYARDLGVLVFENPAKRVMVVTPGGHSDVKRFWKRQKQSS

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.3399	[+] Xl.57863
Unigene EST Profile		EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	GTF2H4
mouse		MGI	Gtf2h4	All(2) Targeted, other(2)
zebrafish		ZFIN	gtf2h4

Publications
First:		The regulation and functions of cdk7. [Prog Cell Cycle Res 1995]
Most recent:		Extended X-ray absorption fine structure evidence for a single metal binding domain in Xenopus laevis nucleotide excision repair protein XPA. [Biochem Biophys Res Commun 1999]
		View All Papers

Functional Ontologies
GO: Molecular:		transcription factor activity
Biological:		DNA repair regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[KL] RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2

Reagents		tropicalis	laevis
Clones		open biosystems
		geneservice/RZPD imagenes
Affymetrix 1.0		Str.51978.1.S1_at [+] Str.3399.2.A1_s_at	Xl.14182.1.A1_at
Affymetrix 2.0			Xl2.14182.1.S1_at

Symbol legend[+]

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