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Summary Expression Gene Literature (11) GO Terms (21) Nucleotides (115) Proteins (33) Interactants (96) Wiki
XB-GENEPAGE-5910007
Gene Symbol:
chuk

Gene Name:
component of inhibitor of nuclear factor kappa B kinase complex

Synonyms:
ikk , IKK-alpha , ikk1 , ikkalpha , ikka ( Add synonyms , Nomenclature history )

Gene Function:
serine/threonine kinase

Protein Function :
Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF...[+]



Interactants:
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Diseases: 


Disease Ontology:
cocoon syndrome

OMIM:
COCOON SYNDROME

External Links:
 
Xenbase Gene ID XB-GENE-5910008 XB-GENE-17344697 XB-GENE-5910051
Gene Symbol chuk chuk.L chuk.S
Chromosome Chr7 Scaffold19
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 549654
444556
mRNA RefSeq RefSeq
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine chuk chuk.L chuk.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CHUK OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Chuk MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Chuk Ensembl
zebrafish
ZFIN, AGR chuk ZFIN Ensembl
chicken
GEISHA CHUK Ensembl
fruit fly
worm
Publications
First IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain., J Biol Chem 1999  
Most Recent Prognostic significance of TPX2 and NIBP in esophageal cancer., Oncol Lett 2019  
All View All Papers 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 21 terms 0 term 8 terms
PANTHER chuk
KEGG Pathways K04467 K04467
KOG [T] TANK binding protein kinase TBK1
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks chuk
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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