kdr Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

XB-GENEPAGE-6053212

[provisional- machine annotated only]

Gene Symbol: kdr [Predicted: Source is Human Entrez Gene]

Gene Name: kinase insert domain receptor (a type III receptor tyrosine kinase) [Predicted: Source is Human Entrez Gene]

Synonyms: flk1, flk-1, vegfr-2, vegfr2, xflk-1 Add Xenopus synonyms

Gene Function: receptor tyrosine kinase

Interactants: aplnr(11) , vegfa(11) , tal1(6) , bmp4(4) , erg(4) , etv2(4) , mpo(4) View All

1/6

XB-GENE-6053213

XB-GENE-6053220

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene	Entrez Gene
mRNA	NCBI Nucleotide >XM_002934669\|PREDICTED: Xenopus (Silurana) tropicalis vascular endothelial growth factor receptor 2-like (LOC100487501), mRNA ATGAGTGCAGTGCTGCCAGGTTGCCTACTGCTGCTGCTCTTGGGCTCACTCATGGCTTCAGACTTTCCAAGCTTAAGTGCTAAGAAAGACCACCTCGTCATTGCTGCCAATGAAACATTAACTATTGCATGCAGGGGACAGAGACCTGTGAATTGGTCGTGGCCAATAAACCACAGCAACAGTATTAATAATCGCTTATCTGTCAGTGAGTGTAATGAAAGTTCCTACTGTCTGACGCTCACACTTACCAAGGTTGTAGCCAATGACAGCGGGATTTACAAGTGCTACTACGAAGACAGTAATGCTACAGCCAGTGTTCGTGTCTTTATTCGGGATGAAAGGTCTCCCTTTGTGCCTTCAATAAGTGAACAACTTCTTGCTGTTTATATCACAGAGAATAAAACAGTGACAGTACCATGCTTGGCCTCTAAACCTGATCTGAATGTCACACTGTGTGCGAAATATCCAGATTCCACATTTCATCCTAATGGTAACAGCATACACTGGGATCACAAAAAGGGATTCACCATTTTAAGTGAATTATTAAAGACTGTGAGCTGGGTCTCCTGTGAAACCAAGCTCAATGGAGAGGTCTATAGATCACCTTCTTATTTTGTATTAGTTGTAGGTTTTAAGATATACAGCCTGTCCATGAATCCCCATCCTCAGGTTCAGCTGGCGGTTGGAGAGAAACTAGCTTTAACGTGCACTGCTCATACTCCCCTAAATGTGAGGGTTGACTTTAAATGGGACTATCCTGCAATAATGGAGAAAAGTGCAGAGACCAAAGGGCTCAAAAAAGAACTTCATGGGGGACTGGAACTTTCAGGGATCTTTATTATCGACTCTGTTACATTGAAAGACAGAGGCAACTACAGCTGCACAGCATACACTGGCCTCATGTCAAAGACCAGCAGTACAACTGTGATTGTACATGTGCCTCCAAAGATATGCGAGAAGGCTGTGCCTGCCCCACTGGATTCTTACAAATATGGCAATCTGTATATTTTAACCTGCACAGCATCTGGAATTCCTACCCCAGTCAGTATAAAGTGGGAGTGGCAGCTGGAAGAAGAGTGTTCTTTTTCCTCATACCAGTATGATATTGGGAAAAACCCCTACACATGTGCAAGATGGAGGGATATTTTTGACAAAAATGGTGGAAATGTGATTGAAACCAATGAAACTCGCACAGATGTCATAGAAGGCAAAGTGAAGACTGTGAGTAAACTGGTCATTCACTCAGCCAGAGTATCTTCTCTGTACCGATGCTCAGCCACAAACCAAGCAGGAGAGGATGAGCATGTGATCTCTTTCCATGTTACCAGAGGCCTAGAAATTGACATGCAGCCGAACAGCAAGCTCACTGAGCGGGACAACATAACATTAATATGCACAGCTGACAAGTTTACTTATGGGAATGTCATGTGGTTCAAGCTTAGTCCCAGCACAGTGGAAAAGCATCATATGGGATGGCCAATACCAGTGTGCAAAAACCTTGTTGGCCTGGTTAGAATGCATGCCACAACTACAAATACCAATGGAGACAACGTGACCTCGGCCCTGGTCCTGCATAACATATCAATGCGTGAACAAGGAAACTATGTTTGTGTTGCACAAGACAAAAAGACCCAGAAAAAATATTGTTTGATCAGACACATAAGAATACAAGCACAAAAAGTTCCCTTTATCTACCAGGACCTGAAAAACCAAACTAGAAATGTCAGTGAAACGGTGGTAGTGAAATGTCAGGCCTCTGGAACGCCTGATCCACAAATCATTTGGTTTAAGGATGACGACAGCCTTGTAGAAGACTCAGGCATTATTTTAAAAGACCATAATAGGACTTTGACTATCCAGAGAGTTCGGAAGGAAGACGAAGGAATCTATTCTTGCAGGGCTTGTAATGACTTGGGATGCACAAAGTCAGAAATGTACTTCACAGTAAATGGCACAGACGAGAAAACAAATCTGGAGCTCATTATTCTGGTTGGCACCGGAATCATTGCCATGTTTTTTTGGGTGCTTCTCGTAATCATCCTCCGGACCGTAAAGAGGCCCAATGGAGGGGAGCTTAAGGCTGGCTATTTGTCAATCATTATGGACCCTGGTGAAGTTCCTATAGAGGAACAGTGTGAGCGGCTTTCTTATGATGCCAGCAAGTGGGAGTTCCCGAGAGATCGTCTCAAATTAGGGAAGCCGCTTGGTCGTGGGGCTTTTGGACAAGTCTTGGAAGCTGATGCCTTTGGAATAGACAAAAGTGGTAGCTGCAAAACTGTAGCAGTAAAAATGCTAAAAGAAGGGGCTACCACCAGTGAACACAGTGCATTAATGTCAGAGCTGAAGATTCTGAGCCATATTGGTCACCATCTAAATGTTGTCAACCTTCTTGGAGCCTGCACTAAACCTGGAGGTCCCTTAATGGTGATTGTGGAATACTGTAAAAATGGCAATCTGTCTGCATATTTAAGAAGCAAAAGAAGTGAATTTGTATTATACAAGACAAAAACACCCCGCTACAGGAAGCAGCACTACGTTGAAGTTTCAAGAGACCTTAAGCGGCGCTTAGATAGTATTGCAAGTAGCCAAAGCTCAGCCAGCTCTGGGTTTGCGGAAGAGAAATCTCTCAGTGATGTTGAGGAAGAAGATGCAGGGGAAGTTTCTGAAGACACATGCAAGAGTTCTTTGTGTATGGAAGATCTGATATCTTACAGCTTTCAGGTGGCCAAAGGCATGGAATATATGGCATCACGTAAGTGCATCCATCGGGACTTAGCAGCGCGCAATATACTCCTGGCAGAAAACAACGTGGTAAAAATCTGTGACTTTGGTCTGGCACGGGATATCTACAAAGACCCTGATTATGTGAGGAAAGGAGATGCTCGTCTCCCTTTGAAGTGGATGGCACCAGAAACCATCTTTGACAGAGTATACACTACACAGAGTGATGTCTGGTCGTTTGGAGTACTTCTTTGGGAAATTTTTTCCTTAGGAGCCTCACCCTATCCTGGAGTTCAAATTGATGAAGACTTCTGCAGGCGGTTAAAAGAGGGGACAAGAATGAGGGCGCCAGAATATGCAACAGTGGAAATATATCAGACAATGTTGGATTGCTGGCATGGGGATCCACAACAAAGGCCTGTTTTTTCAGAGCTAGTAGAGCATTTAGGAAATCTGTTGCAAGCCAGTGTGCAACAGGATGGAAAAGACTATATTCCACTTACAGTATCTTTAAACATTGAAGATGATTCTGGCCTCTCTGTGCCAACTTCACCTGTTTCCTGTATGGAGGAAGAGGAAGTTTGTGATGCAAAATTCCATTATGATAACACAGCTGGATTAAGGTTCCTTCACAGCAGCAGCAAGAGACAGAGCCGTCCTGTTAGTGTCAAGACATTTGAGGACATTCCTGTAGAGCCTGCAGTGAAAGCCATTCAAGATGAGAGCCAGACAGACAGTGGAATGGTTCTTGCATCAGAAGAGCTGAAAACACTGCAAAACAGAACTGACCAAACACAGTTTTTTAGCATTTTGAAGCAGAGTAAAAGCAAGGAATCCGTAACATCAGAGTCTTCGAACCAAACTAGTGATTACCAGTCGGGGTACCATTCTGATGACACGGAGGCAGCTACAGATTCTAATGAAAAGACACAACTACTCCAGAGAAATTCTTCATCAGACACTTGCCATACGGACATCATTCGACATGAAACGGTTCTCCAGTTAAGCACAGATGTTTAA	NCBI Nucleotide >AF007760\|Xenopus laevis receptor tyrosine kinase (flk-1) mRNA, partial cds CTGATTTGCTACAGCTTTCAAGTGGCTAAAGGCATGGAGTTCTTGGCTTCAAGAAAATGTATCCACAGGGACCTAGCAGCACGCAATATACTACTGGCTGAGAACAATGTGGTAAAAATCTGTGACTTCGGTCTGGCACGAGATGTCTACAAAGACCCTGATTATGTCAGAAAAGGAGATGCTCGGCTTCCTTTGAAGTGGATGGCACCAGAAACCATCTTTGACAGGGTATACACTACACAGAGTGATGTTTGTTCGTTCGGAGTACTACTTTGGGAAATCTTTTCCTTAGGAGCTTCGCCCTATCCTGGAGTGCAAATTGATGAAGACTTCTGCAGACGCTTAAAAGAGGGAACAAGAATGAGGGCGCCGGAATATGCAACAGTGGAAATATATCAGACAATGCTGGACTGCTGGCATGGAGATCCACAACAAAGGCCTGTATTTTCTGAACTAGTAGAGCATTTAGGAAATGTGTTGCAAGCCAGTGCGCATCAGGACGGAAAAGACTATATTCCACTCACAGTATCTTTAAACATTGAAGATGATTCTGGAGTTTCTATGCCAACTTCACCTGTTTCCTGCATGGAGGAAGAGGAAGTTTGCGATGCAAAATTCCATTATGATAACACAGCTGGATTAAGGTTTCTTCACAGCAGCAGCAAGAGACACAGCCGCCCTGTTAGTGTCAAGACATTTGAGGACATTCCTGTAGAGCCTGTGGTTAAATCCATTCAAGAAGAGAACCAGACAGATAGTGGAATGATTCTGGCATCAGAAGAACTGAAGACACTGCAGATCAAAGCAGACCAAACACAGTTTTTTAGTATTTTGATGCCCAGTAAAAGCAAGGAGTCAGTTACATCTGAGACGTCAAACCAAACTAGCGACTACCAGTCCGGGTACCATTCCGATGATACGGAGGCAGCTACAGATTCTAATGAAAAGACACAACTACTCAAAAGAATTTCATCATCGGACACTTGCCAACCAGACATCATTTGCCATAAAACTGTTCTCCAGTTAAGCACAGATGTTTA
Protein	NCBI Protein >XP_002934715\|PREDICTED: vascular endothelial growth factor receptor 2-like [Xenopus (Silurana) tropicalis] MSAVLPGCLLLLLLGSLMASDFPSLSAKKDHLVIAANETLTIACRGQRPVNWSWPINHSNSINNRLSVSECNESSYCLTLTLTKVVANDSGIYKCYYEDSNATASVRVFIRDERSPFVPSISEQLLAVYITENKTVTVPCLASKPDLNVTLCAKYPDSTFHPNGNSIHWDHKKGFTILSELLKTVSWVSCETKLNGEVYRSPSYFVLVVGFKIYSLSMNPHPQVQLAVGEKLALTCTAHTPLNVRVDFKWDYPAIMEKSAETKGLKKELHGGLELSGIFIIDSVTLKDRGNYSCTAYTGLMSKTSSTTVIVHVPPKICEKAVPAPLDSYKYGNLYILTCTASGIPTPVSIKWEWQLEEECSFSSYQYDIGKNPYTCARWRDIFDKNGGNVIETNETRTDVIEGKVKTVSKLVIHSARVSSLYRCSATNQAGEDEHVISFHVTRGLEIDMQPNSKLTERDNITLICTADKFTYGNVMWFKLSPSTVEKHHMGWPIPVCKNLVGLVRMHATTTNTNGDNVTSALVLHNISMREQGNYVCVAQDKKTQKKYCLIRHIRIQAQKVPFIYQDLKNQTRNVSETVVVKCQASGTPDPQIIWFKDDDSLVEDSGIILKDHNRTLTIQRVRKEDEGIYSCRACNDLGCTKSEMYFTVNGTDEKTNLELIILVGTGIIAMFFWVLLVIILRTVKRPNGGELKAGYLSIIMDPGEVPIEEQCERLSYDASKWEFPRDRLKLGKPLGRGAFGQVLEADAFGIDKSGSCKTVAVKMLKEGATTSEHSALMSELKILSHIGHHLNVVNLLGACTKPGGPLMVIVEYCKNGNLSAYLRSKRSEFVLYKTKTPRYRKQHYVEVSRDLKRRLDSIASSQSSASSGFAEEKSLSDVEEEDAGEVSEDTCKSSLCMEDLISYSFQVAKGMEYMASRKCIHRDLAARNILLAENNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVQIDEDFCRRLKEGTRMRAPEYATVEIYQTMLDCWHGDPQQRPVFSELVEHLGNLLQASVQQDGKDYIPLTVSLNIEDDSGLSVPTSPVSCMEEEEVCDAKFHYDNTAGLRFLHSSSKRQSRPVSVKTFEDIPVEPAVKAIQDESQTDSGMVLASEELKTLQNRTDQTQFFSILKQSKSKESVTSESSNQTSDYQSGYHSDDTEAATDSNEKTQLLQRNSSSDTCHTDIIRHETVLQLSTDV	NCBI Protein >AAB63281\|receptor tyrosine kinase [Xenopus laevis] LICYSFQVAKGMEFLASRKCIHRDLAARNILLAENNVVKICDFGLARDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVCSFGVLLWEIFSLGASPYPGVQIDEDFCRRLKEGTRMRAPEYATVEIYQTMLDCWHGDPQQRPVFSELVEHLGNVLQASAHQDGKDYIPLTVSLNIEDDSGVSMPTSPVSCMEEEEVCDAKFHYDNTAGLRFLHSSSKRHSRPVSVKTFEDIPVEPVVKSIQEENQTDSGMILASEELKTLQIKADQTQFFSILMPSKSKESVTSETSNQTSDYQSGYHSDDTEAATDSNEKTQLLKRISSSDTCQPDIICHKTVLQLSTDV

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC	Xenbase

Synteny

Expression	tropicalis	laevis
UniGene	Str.60278 [+] Str.83510	Xl.21507
Unigene EST Profile	EST Profile	EST Profile
GEO data		GEO
Images	23 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	KDR	OMIM:602089
mouse	MGI	Kdr	All(16) Targeted, knock Out(1) Targeted, other(13)
zebrafish	ZFIN ZFIN	kdr kdrl	15 Lines(s)

Publications
First:		Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. [Proc Natl Acad Sci U S A 1993]
Most recent:		VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus. [Development 2013]
		View All Papers 8 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		ATP binding protein kinase activity protein serine/threonine kinase activity More[+] protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor receptor activity
Biological:		protein amino acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component:		membrane
EC:		now EC:2.7.10.1 and EC:2.7.10.2
KOG:

Reagents	tropicalis	laevis
Clones	open biosystems	open biosystems
	geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0	Str.29023.1.A1_at	Xl.21507.1.A1_at [+] Xl.21507.1.S1_at
Affymetrix 2.0		Xl2.21507.1.S1_at [+] Xl2.21507.1.A1_at

Symbol legend[+]