Gene Symbol: lefty Gene Name: left-right determination factor Synonyms: leftb, leftyb, lefty-1, antivin, atv, Xlefty, XATV Add Xenopus synonyms Gene Function: Interactants: nodal(36) , nodal1(18) , pitx2(13) , tgfb1(12) , shh(9) , cer1(8) , t(8) View All

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		Refseq >NM_001130253|Xenopus (Silurana) tropicalis left-right determination factor (lefty), mRNA GGGAAGGAAGGAGTGAAAGGCACTTGCACCCTGATCACTGTCACAGCAAGATGGGTGTCACTAGCACATGTCTCTGCCTGATCCTCAGCACCCTGTGCCTGGCTGCCAGCAGCGCCTTCAGCCCCGACCATATCCGAGATGCTCTGCTCAGAAAACTCAACCTCCAGGAGCCCCCCAAGCTGGAGAAAAGGGACGTGGAGAAGCTGCTGATCCCCAGGCACATCCAAGCCAAGTACATGTCTATGCTTCATACTCACAGGGAGAGGAAGAGGAGATCCCTGCCCAGCTTGGCTGGCATCCTCAGGGGCATCTCTGGCAACGCAGATATTGCCGGGGAGATTGTGTATTCAGACTCCAGCAAGCAAACCTTGGTGTTTGGAATGGAGTCCCGAATCCCAGAGAACAGTGAGGTGACTATGGCTGAACTCAAGCTCTTCAAGAAACCCCCCCAAATCATGAACGTCCCAGAGAGGAGATTCCACCGACCGGTCAATAACGCCAGAGTCAGTGTGTACTATGTGGAGATGCTCACAGATGGGACCAACAGAACCTCCCTGGTGGACTCTAGGCTTGTGCCCATCATGGAGTCGGGCTGGAGGAGCTTTGACGTGACCCAGGCTGTGCAGTACTGGACAAGGAGCGGGGGGCAGTCACCGATGCACTTAGAGATCCGGGTGGATGGGGAGCGACATGGAAGTCATGCGTCTGAGATGGCAAAGTTGGTTCGTTTCACCACCCAGAGCGCTTCGGATAACTCTCTGGGGAAACCAGAACTTGTTCTATACACACTCAACCTGGATGAGCATGGGGCCCGCGGCGACTGCTCGGCATCAGGTGCCCAAAAAGACCACATCTGCTGCAGGGAGGAACATTTCATTAACTTCCGGGAGCTTACCTGGACACAGTACTGGATTATAGAACCGGCGGGATACAACGCGTTTCACTGCACAGGAAGTTGCAAGCAACCCAAGTTCCCCTTGTCCCATTATCACTATGGGCAGCGAACGTGCGCTGTGGTGGAAAGCGCCCCGCTGCCCGTCATGTACCTGGTCAAAAAGGGCGACTACACGGAAATCGAAGTGGCGGAATTCCCCAATATGATAGTTGAAAAATGCGGTTGCACCATGGACAATATCGCTATCATATGATTGGTGGTGTGTGTAGTACTTGCAAATGTGCTCTTAGTAACCAGGCAGGGGCCCATTATATAAAGTGGCACCTTTGGGCCCCTCCAGCTGTCAAGAGGGTGCTGGGAGTTGTGCTTTAACACCAACTGAAGGGATGCAGTTTGGGCAAACTGATGTAATGCGTTAGTATTGCCACTTTTCCCTACTATCACCATCATGCCCTACTACTATAGTAACTACTATAGGTGCAGCTGCACGTTCAGACTTTTTCTGCTTAAACGAGACGTGCAGTCGCCCCTGTTTGCACCCACCCCGAGGCAGCTCTGTCAGTAACCGAACCGTAAGCCCACGGTTTTACCCAGCGCAAAATCTTACCGCTCCCCCCGGGAGTTTGTAAAAAAAAAAAAAGCAGCGACGATTTACAATCTTAGTAATGTCTGTGGCAGAACGATAGAAGCATTTAGAGAAGCACTTACCTGTAAATAGACTGATATAGATATTTATCTCTTGTTGACCCAGCCAACACTGCGGCGTGGAGATGGCTCATAAAATATGAATTAATGACGGAGGTATTTCTATTGGAAGATCGTTTCAGCATCATTTTTCAATTCTATATATATATATATATAATGGAAAGTTTAATCAAACAATAAAGTTTGTGATGAAATTAAAAAAAAAAAAAAAAA	Refseq >NM_001085745|Xenopus laevis left-right determination factor (lefty-a), mRNA GGCACGAGCTTGAGGGAAGGAAGAAGTGATACGCACTTGCACCCTGTAGACTGTCACATCAGAATGGGTGTCACTACCAAATCTTTGAGGCTCTGCTTGATCTTCAGCACCCTGTGCCTGGCTGCCATCAATGGCTTCAACCCTGACAACATCAGAGATGCTCTGCTCAAAAAACTCAACCTCCAAGAGGTTCCCAAACTGGAGAAAAGAGACGTTGAGAACCTGGTGATCCCTAGGCACATCCAAGCCAAATACATGTCTATGCTGCACAGTCACAGAGAGAGGAAGAGGAGATCACTGCCCAGCTTGGCTGGCATCCTCAGGGGCATCTCAGGCAATGCAGATATTTCTGGGGAGATTCTATACTCAGACTCCAGCAAGCAGACCATGGTCTTTGGAATGGAGTCCCGTATTCCAGAGAACAGTGAGGTGACCATGGCTGAACTCAAGCTCTTCAAGAAACCCCCTAAAATCATGAACGTCCCAGAGAGGAGATTCCACCGACCAGTCAGCAATGCCAGAGTCAGTGTGTATTATGTAGAGATATTGAAAGATGGGACCAACAGAACCTCCCTGGTGGACTCTAGGCTTGTGCCAATTATGGAGTCAGGCTGGAGGAGCTTTGATGTGACCCAGGCTGTGCATTACTGGATGAAAAGTGGCGGACATTCATCGATGCACTTAGAGATCCACGTGGATGGTGAACGACATGGAAGTCATGCATCTGAGATGGCAAAAATGGTTCGTTTCACCACCCAGAGCCCATCAGACAACTCTCTGGGAAAACCAGAACTTGTCTTGTTCACTCTCAACCTTGATGAGCATGGGGCCCGTGGAGACTGTTCAGCATCAGGTGCTAAAAAAGACAACATCTGCTGCAGAGAGGAATATTTCATTAACTTTCGGGAGCTTACCTGGACACAGTACTGGATTATTGAGCCAGCAGGATATAATGCTTTTCGGTGCGCAGGAAGTTGCAAGCAACCAAAGTACCCCTTGTCTCATCACTATGGAGAGAGAATGTGCGCCGTGGTGGAAAGTGCCCCACTGCCCGTTATGTACCTGGTCAAAAAGGGAGACTACACGGAAATCGAAGTGGCAGAATTCCCCAATATGATTGTGGAAAAATGCGGTTGCACAATGGACAATATCGCTATAATATGAGGAATGGCAGCACTGAGTTCTTGCAGATCTGCTGTGTGTAGTACTTGCAAATGTGCTCTTAGTAAGCAGGCATGTCTGTAGTGCTGGCAGGAGCCCATTATATATAGTAGAACTGTGCACCTTTTGGCCTCTCCAGCTGTCAAAAGGGTGCTGGGAGTTGTGCTTTAACAGCAACTGAAGGGATGCCGTTTGGCCAAACGAATGTAATGTGTGCCCTACTATCACCATCTTGCCTTACTGACAAGTGTTACTACTATAGGTGCTGCTGCACATTAAAAAAAGTTGCCTTCCCCAGACTTTATCTGCTTCAAAGGGATGTGGAAGGCACAGGGCAGATGCCCCTGCTTGCACCCACCCTGATGAACGCTCTGTTAGTAACTGAACCATAAACCTATGGTTTAACCTAGTGCAAATATCACCGCTCCTTCTGGGAGTTTATAAAAGCAACGACAATTTCCGATCTCAGTGATCAGAATGGCAGAATGATAGAAGCATTTAGAGAAGCACTTACCTGTAAATAGACTGATATAGATATTTATCTCTCGTTGACTTGGCCACACTGCGGCATGGAGATGGCTCATAAAATATGAATTTGACAGAGGTATTTCTATTGGATGATCATTGCAGCATATTTTTTCAATTATATATATATATAAAGAAAACAGAAACTTTAATCAAACAATAAAGTTTGTGATGAAACTAAAAAAAAAAAAAAAAAAAAAA		Refseq >NM_001088574|Xenopus laevis left-right determination factor (lefty-b), mRNA GGCACGAGGGAAGAAGTGATAGGCACTTGCACCCTGTGTCACATCAGAATGGGTGTCACTACCAAATCTTTGAGACTCTGCTTGATCTTCAGCACCCTGTGCCTGGCTGGCATCAGTGCCTTCAACCCAGATGACATCAGAGATGCTCTGCTAAAAAAACTCAACCTCCAAGAGGTCCCCAAACTGGAGAAAAGAGACGTGGAGAACCTGGTGATCCCCAGGCACATCCAAGCCAAGTACATGTCTATGCTGCACAATCACAGAGAGAGGAAGAAGAGATCACTGCCCAGCTTGGCTGGCATCCTCAGGGGCATCTCGGGCAATGCAGATATTTCCGGGGAGATTCTGTACTCAGACTCCAGCAAGCAGTCCCTGGTTTTTGGAATGGAGTCCCGTATCCCAGAGAACAGTGAGGTTACCATGGCTGAACTCAAGCTCTTCAAGAAACCCCCTAAAATCATGAACGTTCCAGAAAGGAGATTCCACCGACCTGTCAACAATGCCAGAGTTAGTGTGTATTATGTGGAGATATTGAAAGATGGCACCAACAGAACCTCCCTGGTGGACTCTAGGCTTGTGCCAATCATGGAGTCGGGCTGGAGGAGCTTTGACGTGACCCAGGCTGTGCATTACTGGATGAGAAGTGGTGGACAGTCATCAATGCACTTAGAGATCCACGTGGATGGGGAGCGACATGGAAGTCATGCATCTGAGATGGCAAAGATGGTTCGTTTCACCACCCAGAGCCCATCAGACAACTCTCTGGGAAAACCAGAGCTTGTCCTGTTTACTCTCAACCTCAATGAGCAGGGGACCCGTGGAGACTGCTCAGCATCAGGTGCCAAGAAAGACAACATCTGCTGCAGAGAGGAATATTTCATTAACTTTCGGGAACTTACCTGGACACAGTACTGGATTATTGAGCCAGCAGGATACAACGCTTTTCGGTGCACTGGAAGTTGCAAGCAACCAAAGTACCCCTTGTCTCATTATCACTATGGACAGAGAACATGCGCCGTGGTGGAAAGCGCCCCACTACCCGTAATGTACCTGGTCAAAAAGGGAGACTACACGGAAATCGAAGTGGCGGAGTTCCCTAATATGATTGTCGAAAAATGCGGTTGCACAATGGACAATATCGCTATCATATGACAGATGGCAGCACTAAGTTCATGCAGATCCGGTGTGTGTAGTACTTGCAAATGTGCTCTTAGTAACCAGGCATGTGTTCAGTGCTGGCAGGGGCCCATTTCGTAAAGTAGGACTGAGCGCCTTTTGGCCTCTACAGCTTTTAAAAGGATGCTGTGAGTTGTACTTTAACAGCAGGGTTGCAGTTTGGGCAAACTGATGTAATGTGCACCCTGCTGTCACCATCTTGCCCTACTGACAGGTGTTAGTTACTACTGCCTCAAAGGGATGTGGAGGGCCCAGTGCAGCTGCCCCTGCACTTACCCTGAAGACAGCCCTGTTAGCAACGGAACCGTAAGAATATGGTTTTACCTAGACCAAATCTTACTACTCCTTCTGGGAGTTTGTAAAAGCAGCGACAATTTCCGATCTCAGTAATGTCTGTGGCAGAATGATAGAAGCATTTAGAGAAGCACTTACCTGTAAATAGACTAATATAGATATTTATCTCTCGTTGACTCAGCCACACTGCGGCATGGAGATGGCTCATAAAATATAAATTTGACAGAGGTATTTCTATTGGAAGATCATTTCAGCATATTTTTTAAATTCTATAAATATATATATAACGGAAACTTTAATCAAACAATAAAGTTTGTGATGAAAATAAAACAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001123725|left-right determination factor precursor [Xenopus (Silurana) tropicalis] MGVTSTCLCLILSTLCLAASSAFSPDHIRDALLRKLNLQEPPKLEKRDVEKLLIPRHIQAKYMSMLHTHRERKRRSLPSLAGILRGISGNADIAGEIVYSDSSKQTLVFGMESRIPENSEVTMAELKLFKKPPQIMNVPERRFHRPVNNARVSVYYVEMLTDGTNRTSLVDSRLVPIMESGWRSFDVTQAVQYWTRSGGQSPMHLEIRVDGERHGSHASEMAKLVRFTTQSASDNSLGKPELVLYTLNLDEHGARGDCSASGAQKDHICCREEHFINFRELTWTQYWIIEPAGYNAFHCTGSCKQPKFPLSHYHYGQRTCAVVESAPLPVMYLVKKGDYTEIEVAEFPNMIVEKCGCTMDNIAII	Refseq >NP_001079214|left-right determination factor precursor [Xenopus laevis] MGVTTKSLRLCLIFSTLCLAAINGFNPDNIRDALLKKLNLQEVPKLEKRDVENLVIPRHIQAKYMSMLHSHRERKRRSLPSLAGILRGISGNADISGEILYSDSSKQTMVFGMESRIPENSEVTMAELKLFKKPPKIMNVPERRFHRPVSNARVSVYYVEILKDGTNRTSLVDSRLVPIMESGWRSFDVTQAVHYWMKSGGHSSMHLEIHVDGERHGSHASEMAKMVRFTTQSPSDNSLGKPELVLFTLNLDEHGARGDCSASGAKKDNICCREEYFINFRELTWTQYWIIEPAGYNAFRCAGSCKQPKYPLSHHYGERMCAVVESAPLPVMYLVKKGDYTEIEVAEFPNMIVEKCGCTMDNIAII		Refseq >NP_001082043|left-right determination factor precursor [Xenopus laevis] MGVTTKSLRLCLIFSTLCLAGISAFNPDDIRDALLKKLNLQEVPKLEKRDVENLVIPRHIQAKYMSMLHNHRERKKRSLPSLAGILRGISGNADISGEILYSDSSKQSLVFGMESRIPENSEVTMAELKLFKKPPKIMNVPERRFHRPVNNARVSVYYVEILKDGTNRTSLVDSRLVPIMESGWRSFDVTQAVHYWMRSGGQSSMHLEIHVDGERHGSHASEMAKMVRFTTQSPSDNSLGKPELVLFTLNLNEQGTRGDCSASGAKKDNICCREEYFINFRELTWTQYWIIEPAGYNAFRCTGSCKQPKYPLSHYHYGQRTCAVVESAPLPVMYLVKKGDYTEIEVAEFPNMIVEKCGCTMDNIAII

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny

Expression		tropicalis	laevis a		laevis b
UniGene		Str.57186	Xl.708		Xl.1044
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		13 expression image(s) for tropicalis and laevis

Phenotype		tropicalis	laevis a		laevis b
Smith Morpholino Screen		tgas031a08

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human
mouse
zebrafish

Publications
First:		Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. [Genes Cells 1997]
Most recent:		Serotonin has early, cilia-independent roles in Xenopus left-right patterning. [Dis Model Mech 2013]
		View All Papers 11 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:
Cellular Component:
EC:
KOG:

Reagents		tropicalis	laevis a		laevis b
Clones			EXRC - 1 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.14828.1.S1_at	Xl.708.1.S1_at		Xl.1044.1.S1_at
Affymetrix 2.0			Xl2.708.1.S1_at		Xl2.1044.1.S1_at

Symbol legend[+]

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   - Literature Or Expression Images