Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (167) GO Terms (11) Nucleotides (178) Proteins (34) Interactants (1773) Wiki
XB-GENEPAGE-478517
Gene Symbol: not

Gene Name: notochord homeobox

Synonyms: Xnot , noto , Xnot-2 , Xnot2 , flh , floating head , Znot , not-a , not-b , not1 , Xnot1 ( Add synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor

Protein Function :
Transcriptional repressor. Plays a fundamental role in notochord formation, acting within the mesodermal region. Acts downstream of gsc and upstream of chrd and foxa4-A/pintallavis.

Interactants: Loading ...
Diseases:  External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
1/7
 
Xenbase Gene ID XB-GENE-478518 XB-GENE-6252631 XB-GENE-865187
Gene Symbol not not.L not.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100038059
397703
397961
mRNA RefSeq RefSeq RefSeq
Protein RefSeq TrEMBL RefSeq Swiss-Prot TrEMBL RefSeq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine not not.L not.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tgas141c24      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM Protein Atlas, Allen Brain Atlas
mouse
MGI, IMPC Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR noto ZFIN Ensembl
chicken
fruit fly
FLYBASE not Ensembl
worm
WORMBASE
Publications
First The evolution of vertebrate gastrulation., Dev Suppl 1992  
Most Recent The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer., Elife 2020                                                          
All View All Papers 40 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 9 terms 5 terms 5 terms
PANTHER not
KEGG Pathways
KOG [K] Transcription factor EMX1 and related HOX domain proteins
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks not
ORFs not.L ORF1 not.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.13.0


Major funding for Xenbase is provided by grant P41 HD064556