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Summary Expression Gene Literature (513) GO Terms (10) Nucleotides (293) Proteins (46) Interactants (2414) Wiki
Gene Symbol: otx2

Gene Name: orthodenticle homeobox 2

Synonyms: Xotx2 , otx-2 , Xotx-2 , otxA , otx2-a , otx2-b ( Add synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor

Protein Function :
May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer ...[+]

Interactants: Loading ...
Diseases:  Disease Ontology: microphthalmia


External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
Xenbase Gene ID XB-GENE-485220 XB-GENE-485224 XB-GENE-6254039
Gene Symbol otx2 otx2.L otx2.S
Chromosome Chr08 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 548931
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq TrEMBL Swiss-Prot RefSeq TrEMBL Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine otx2 otx2.L otx2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tgas114a06      
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards OTX2 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Otx2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR ZFIN, AGR otx2b otx2a ZFIN Ensembl
fruit fly
First Neural induction by the secreted polypeptide noggin., Science 1993  
Most Recent Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction., Dev Biol 2020          
All View All Papers 136 paper(s) referencing morpholinos 10 paper(s) referencing OMIMs 20 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 9 terms 4 terms 5 terms
KEGG Pathways K18490 K18490 K18490
KOG [K] Homeobox transcription factor
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks otx2
Mutants Xtr.otx2emHorb
Antibodies Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4 Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4 Otx2 Ab1 , Otx2 Ab2 , Otx2 Ab3 , Otx2 Ab4
Morpholinos otx2 MO1 , otx2 MO2 , otx2 MO3 otx2 MO1 , otx2 MO2 , otx2 MO3 otx2 MO1 , otx2 MO2 , otx2 MO3
ORFs otx2 ORF1 otx2.L ORF1 otx2.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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