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Summary Expression Gene Literature (12) GO Terms (14) Nucleotides (147) Proteins (30) Interactants (218) Wiki
XB-GENEPAGE- 955517

Gene Symbol: fen1

Gene Name: flap structure-specific endonuclease 1

Synonyms: mf1 , rad2 , fen-1 , fen1-a , fen1-b
Add Xenopus synonyms , Nomenclature history


Gene Function: 5'-3' exonuclease

Protein Function :
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is ...[+]


Interactants: Loading ...

Disease Ontology Associations:

OMIM Disease Associations: FLAP STRUCTURE-SPECIFIC ENDONUCLEASE 1; FEN1
 
Xenbase Gene ID XB-GENE-955518 XB-GENE-955523 XB-GENE-6254462
Gene Symbol fen1 fen1.L fen1.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.3319 Xl.440 Xl.530
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine fen1 fen1.L fen1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards FEN1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Fen1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR fen1 ZFIN Ensembl
chicken
GEISHA FEN1 Ensembl
fruit fly
FLYBASE Fen1 Ensembl
worm
WORMBASE
Publications
First: Complementation of the DNA repair defect in xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2. [Nature 1993]
Most recent: HMGB1 Stimulates Activity of Polymerase β on Nucleosome Substrates. [Biochemistry 2017]
View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 10 terms 13 terms 13 terms
PANTHER fen1
KEGG Pathways K04799 K04799 K04799
KOG [L] 5'-3' exonuclease (alt_id KOG:2519)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
ORF fen1 ORF1
Affymetrix 1.0 Str.3319.1.S1_at Xl.440.1.S1_at Xl.530.1.S1_at
Affymetrix 2.0 Xl2.440.1.S1_s_at Xl2.530.1.S1_at

Symbol legend[+]
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