Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (21) GO Terms (21) Nucleotides (288) Proteins (42) Interactants (425) Wiki
XB-GENEPAGE-6258451
Gene Symbol:
cbl

Gene Name:
Cbl proto-oncogene, E3 ubiquitin protein ligase

Synonyms:
c-cbl , rnf55 ( Add synonyms , Nomenclature history )

Gene Function:


Protein Function :
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
juvenile myelomonocytic leukemia

OMIM:
JUVENILE MYELOMONOCYTIC LEUKEMIA; JMML [+]

External Links:
1/2
 
Xenbase Gene ID XB-GENE-6258452 XB-GENE-6251913 XB-GENE-17339778
Gene Symbol cbl cbl.L cbl.S
Chromosome Chr07 chr7L Scaffold106
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 594900
398194
108705407
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq NCBI Protein NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine cbl cbl.L cbl.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CBL OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Cbl MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Cbl Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR cbl cblb ZFIN Ensembl
chicken
GEISHA CBL Ensembl
fruit fly
FLYBASE Cbl Ensembl
worm
Publications
First Functional expression of transcobalamin II cDNA in Xenopus laevis oocytes., Biochem Biophys Res Commun 1991  
Most Recent Conservation and divergence of protein pathways in the vertebrate heart., PLoS Biol 2019                                                      
All View All Papers 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 21 terms 9 terms 6 terms
PANTHER cbl
KEGG Pathways K04707 K04707 K04707
KOG
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks cbl
Clones Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556