lefty Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

Gene Literature (99)

XB-GENEPAGE-6258962

Gene Symbol:

lefty

Gene Name:

left-right determination factor

Synonyms:

leftb , leftyb , lefty-1 , antivin , atv , Xlefty , XATV , lefty1 , lefty-a , lefty-b ( Add synonyms , Nomenclature history )

Gene Function:

Protein Function Downloaded from UniProtKB

InterPro

TGF-beta-rel , Cystine-knot cytokine , TGFb CS , TGF-b propeptide [+]

Interactants:

Loading ...

Diseases:

External Links:

MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, dbVAR, GHR, gnomAD

Xenbase Gene ID

XB-GENE-6258963

XB-GENE-6252409

XB-GENE-6251914

Gene Symbol

lefty

lefty.L

lefty.S

Chromosome

Chr5

chr5L

chr5S

Molecules

X. tropicalis

X. laevis.L

X. laevis.S

Genomic Sequence

Version 9.1

>lefty 9.1 
							GGGAAGGAAGGAGTGAAAGGCACTTGCACCCTGATCACTGTCACAGCAAGATGGGTGTCACTAGCACATGTCTCTGCCTGATCCTCAGCACCCTGTGCCTGGCTGCCAGCAGCGCCTTCAGCCCCGACCATATCCGAGATGCTCTGCTCAGAAAACTCAACCTCCAGGAGCCCCCCAAGCTGGAGAAAAGGGACGTGGAGAAGCTGCTGATCCCCAGGCACATCCAAGCCAAGTACATGTCTATGCTTCATACTCACAGGGAGAGGAAGAGGAGATCCCTGCCCAGCTTGGCCGGCATCCTCAGGGGCATCTCTGGCAACGCAGGTATGCCGAGTCCTATTCACGACTTGCTCATTGTAACCTTGGGATAGGACGTTACTACGGTCGCGGCGACTGTACCCCGATTTATTCTGTATTGCCGGGTACCTGTGTGTCAGTCTGGAATGCAGGGAGTTTCCAGACAGGGGGCTATTGATAGTCTGGGGCATTAGTGGATTGCGCAGCTGGGTGAATGTGGCATTTTGATATTTCGACCTCTTGATGTGCACTTTTTGTGTATATGGGGATTTATTCTAATTGACCCTTTCATGTCTGGGTTCCTGCTGCCTGGAAGTCCCCAGTTGTTATGCTAATGGCCCAACTTGGCCGCTCCACCCTGACTGGCTGGGGATCCCGGACCTAGACACGTCatccataataataattttagcaataataataataatctttattcCATCATTTAGATATTGCCGGGGAGATTGTGTATTCAGACTCCAGCAAGCAAACCTTGGTGTTTGGAATGGAGTCCCGAATCCCAGAGAACAGTGAGGTGACTATGGCTGAACTCAAGCTCTTCAAGAAACCCCCCCAAATCATGAACGTCCCAGAGAGGAGATTCCACCGACCGGTCAATAACGCCAGAGTCAGTGTGTACTATGTGGAGATGCTCACAGATGGGACCAACAGAACCTCCCTGGTGGACTCTAGGTAGGTCAGACCAACCGGCTACACAGTCACCTGTTCGCTGCTAGCCAGAGCCATAGGGAGGGATTATTAGCGCTTATCTTGGATATCTCTCTTTGTGATTCTATGATGATGATTAGTAAAGTCAGTGATCCTCTCAACCAGCAAGAATAGAAAGAACAGAGGGGTTTCACCCAGTAACTTcataataaatgtgaaaaaatcagtggtttatttttttttacattaattttgaaGTCCCTGAGTGCCTCTCTGCATCATTATATACATTActttttgtaaaaatttttttacTTTGGCTTCCTgactatctgtctatcatctatctgtctatcatctatctatctatcatctatctatctatcatctatctatctatctatctatctatctatctatctatctatctatctatctatctatctatctatcatctatctatctatctgtctatcatctatctgtctatcatctatctatctatcatctatctatctatctatctatctatctatctatctatctatctatctgtctatcatctatctatcatcatcatctatcatttctctctatctctccatctgtctatctatctatctatctatctctccatctatctatatatcatctatctatgtatctctccatctatctatctgtcatctatctattatctatctatctatctatctatctatctatctatctatctatctatcatcatctttcTCTATCtctcaatctatctatctatcatcatctttctctctctctctatctctccatctatctatctatctatctatctatctatctatctatctatctatctatctatctatcatctatctatctatcatcatctttctctctctatctatctttctatcatctatctatctatctatctatctatctatctatctatcatcatctttctctctctctctatctctccatctatctatctatctatctatctatctatctatctatctatctatctatctatctatcatctatttatctatctatcatctatctatctatctatctatctatctatctatctatctatcatctatttatctatctatcatctatctatctatctatctatctatatctatcatcatctttctctctctctctatctctccatctatctatctatctatctatctatctatctatctatctatctatcatctctctctctctctctctctctctctctctatcatctatctatctatctatctctccatctatctatctatctatctatctctccatctatctatctatctatctatctatctatctatccaataTAATATGTATTTCCAATTCCTTCCTTCTATAATCTTGCATATAGAATGCCCAGATACATAAACATGGTGACTATAATGCTAATAGGACTAACACCTTCCCGTTTATGTTTGCAGGCTTGTGCCCATCATGGAGTCGGGCTGGAGGAGCTTTGACGTGACCCAGGCTGTGCAGTACTGGACAAGGAGCGGGGGGCAGTCACCGATGCACTTAGAGATCCGGGTGGATGGGGAGCGACATGGAAGTCATGCGTCTGAGATGGCAAAGTTGGTTCGTTTCACCACCCAGAGCGCTTCGGATAACTCTCTGGGGAAACCAGAACTTGTTCTATACACACTCAACCTGGATGAGCATGGGTAAGTGTATCCTTAGTTACTCGGAGCCCTTTAGGATTTGCCATACAGTTGACCAGACTAGGAATGTTCTTTACTAAGGGCTAGGCCATGGCGCCTCCTAGCTTCCAAACTAGTCATGAGtttcttaataaccccctgtttgtattaatgtattctactgtacagcgctgcgtacataagtagcactttataaagatatacatacatacatacaatagccTTAATACCAATATACATTTACTATTTCCTTGTTCTAAACCAATTTCTCTTTGTACGTTCAGGGCCCGCGGCGACTGCTCGGCATCAGGTGCCCAAAAAGACCACATCTGCTGCAGGGAGGAACATTTCATTAACTTCCGGGAGCTTACCTGGACACAGTACTGGATTATAGAACCGGCGGGATACAACGCATTTCACTGCACAGGAAGTTGCAAGCAACCCAAGTACCCCTTGTCCCATTATCACTATGGGCAGCGAACGTGCGCTGTGGTGGAAAGCGCCCCGCTGCCCGTCATGTACCTGGTCAAAAAGGGCGACTACACGGAAATCGAAGTGGCGGAATTCCCCAATATGATAGTTGAAAAATGCGGTTGCACCATGGACAATATCGCTATCATATGATTGGTGGTGTGTGTAGTACTTGCAAATGTGCTCTTAGTAACCAGGCAGGGGCCCATTATATAAAGTGGCACCTTTGGGCCCCTCCAGCTGTcaagagggtgctgggagttgtgcttTAACACCAACTGAAGGGATGCAGTTTGGGCAAACTGATGTAATGCGTTAGTATTGCCACTTTTCCCTACTATCACCATCATGCCCTACTACTATAGTAACTACTATAGGTGCAGCTGCACGTTCAGACTTTTTCTGCTTAAACGAGACGTGCAGTCGCCCCTGTTTGCACCCACCCCGAGGCAGCTCTGTCAGTAACCGAACCGTAAGCCCACGGTTTTACCCAGCGCAAAATCTTACCGCTCCCCCCGggagtttgtaaaaaaaaaaaagcagcgaCGATTTACAATCTTAGTAATGTCTGTGGCAGAACGATAGAAGCATTTAGAGAAGCACTTACCTGTAAATAGACTGATATAGATATTTATCTCTTGTTGACCCAGCCAACACTGCGGCGTGGAGATGGCtcataaaatatgaattaatgaCGGAGGTATTTCTATTGGAAGATCGTTTCAGCATCATTTttcaattctatatatatatatatataatggaaagtTTAATCAAACAATAAAGTTTGTGATGAAATTA

Version 9.2

>lefty.L 9.2 
							CTTGAGGGAAGGAAGAAGTGATACGCACTTGCACCCTGTAGACTGTCACATCAGAATGGGTGTCACTACCAAATCTTTGAGGCTCTGCTTGATCTTCAGCACCCTGTGCCTGGCTGCCATCAATGGCTTCAACCCTGACAACATCAGAGATGCTCTGCTCAAAAAACTCAACCTCCAAGAGGTTCCCAAACTGGAGAAAAGAGACGTTGAGAACCTGGTGATCCCTAGGCACATCCAAGCCAAATACATGTCTATGCTGCACAGTCACAGAGAGAGGAAGAGGAGATCACTGCCCAGCTTGGCTGGCATCCTCAGGGGCATCTCAGGCAATGCAGGTACGACAAGCCCTCATTTCATCATTTTATTATGACAATAACACATTGCTAATTATAATATTAGTATAGTATTAATTATATTACACAATCGAAGTTCTTGATATTGATTGAGTGAGTGCGTTAGGGTTGTAGCTAGGGTTCCAGCCATTGTAGCCCCCGATTTATTCTTTATTGCCGGATACCCTCATGAATCATTTATCTGCCTGTCTGAAATTGAGGGAGTTTCCAGACAGGGGGTTATTTATAGTCTGGGGTATTAGTGAATTGCATAGGTGAATTTTGATATTTTGGCCTCTTGATGTTTACAGCCAGAATGCATTTTTTGTGTATAGGGGGATTTATTTTAATTGACCCTTTCATGTCTGGGATCCTGCTACCTGGAAGTCGTCAGTTGTTATGCTAATGCACATGTTGATGTTCCAGCAGTACAATAACTTGATCGCTCCACCCTGACTGTAGTGACTGGAGTTCATGACACATATATATGTAAACCATAATAATATTAATGAGTTTGCTAATCTCCTTGGTTTTTTTTCATTAGATATTTCTGGGGAGATTCTATACTCAGACTCCAGCAAGCAGACCATGGTCTTTGGAATGGAGTCCCGTATTCCAGAGAACAGTGAGGTGACCATGGCTGAACTCAAGCTCTTCAAGAAACCCCCTAAAATCATGAACGTCCCAGAGAGGAGATTCCACCGACCAGTCAGCAATGCCAGAGTCAGTGTGTATTATGTAGAGATATTGAAAGATGGGACCAACAGAACCTCCCTGGTGGACTCTAGGTAGGTAACCCAACCATAAACTATATCACATGTTTCTGAGATACTTGGTATCTTCCTGTAATCAAATCCATTTAAATATAATATTCATAATACTCTTTAGGATCAGCTGAAAGATAAAAAGGAGTTATCTTGGAAATGTGATCTTTTTACTACGCAGCTACTATGATTCTTTGATTCTGGTTGCTAAAATCAGATTCATTGTCCACATATATAAATTTCAGTGTTGTTCTTAGTATCTAGACCTAACAATATGTGATTGTTATGCTAATGAGACTGGGATTCTCAGGATGTTTAAAGAACTCATGTCCTCACTTAATATTTTCAGGCTTGTGCCAATTATGGAGTCAGGCTGGAGGAGCTTTGATGTGACCCAGGCTGTGCATTACTGGATGAAAAGTGGCGGACATTCATCGATGCACTTAGAGATCCACGTGGATGGTGAACGACATGGAAGTCATGCATCTGAGATGGCAAAAATGGTTCGTTTCACCACCCAGAGCCCATCAGACAACTCTCTGGGAAAACCAGAACTTGTCTTGTTCACTCTCAACCTTGATGAGCATGGGTAAGTCCCTTTTTAGTTACTTCTTCTTTGCCTTAAAGTTTCTTAGATATGACATGAGCTGATATGTTCAGACTGTCATCCACTGTTTTTGAACAGCACCCCCAAATGGACATGCTGAAGAAACGCAATGTCCTGTGCTAAGGGAAACACCATGATATATGTATAAATACAAATATACAGAGAATGAATGTCCTGTGCACACAATATAAGATTAAACCCCTTCAACTGATAATGAAGTTCTATTATTTATGGCCAGTTCCTATCATTAATAAATGAAATATGCAAACAGACTATGTAGAATAACATTAAAACCGATATAAAATGTAATTGTTCTGAACCAATTTTGCTTTTACTTGCAGGGCCCGTGGAGACTGTTCAGCATCAGGTGCTAAAAAAGACAACATCTGCTGCAGAGAGGAATATTTCATTAACTTTCGGGAGCTTACCTGGACACAGTACTGGATTATTGAGCCAGCAGGATATAATGCTTTTCGGTGCGCAGGAAGTTGCAAGCAACCAAAGTACCCCTTGTCTCATCACTATGGAGAGAGAATGTGCGCCGTGGTGGAAAGTGCCCCACTGCCCGTTATGTACCTGGTCAAAAAGGGAGACTACACGGAAATCGAAGTGGCAGAATTCCCCAATATGATTGTGGAAAAATGCGGTTGCACAATGGACAATATCGCTATAATATGAGGAATGGCAGCACTGAGTTCTTGCAGATCTGCTGTGTGTAGTACTTGCAAATGTGCTCTTAGTAAGCAGGCATGTCTGTAGTGCTGGCAGGAGCCCATTATATATAGTAGAACTGTGCACCTTTTGGCCTCTCCAGCTGTCAAAAGGGTGCTGGGAGTTGTGCTTTAACAGCAACTGAAGGGATGCCGTTTGGCCAAACGAATGTAATGTGTGCCCTACTATCACCATCTTGCCTTACTGACAAGTGTTACTACTATAGGTGCTGCTGCACATTAAAAAAAGTTGCCTTCCCCAGACTTTATCTGCTTCAAAGGGATGTGGAAGGCACAGGGCAGATGCCCCTGCTTGCACCCACCCTGATGAACGCTCTGTTAGTAACTGAACCATAAACCTATGGTTTAACCTAGTGCAAATATCACCGCTCCTTCTGGGAGTTTATAAAAGCAACGACAATTTCCGATCTCAGTGATCAGAATGGCAGAATGATAGAAGCATTTAGAGAAGCACTTACCTGTAAATAGACTGATATAGATATTTATCTCTCGTTGACTTGGCCACACTGCGGCATGGAGATGGCTCATAAAATATGAATTTGACAGAGGTATTTCTATTGGATGATCATTGCAGCATATTTTTTCAATTATATATATATATAAAGAAAACAGAAACTTTAATCAAACAATAAAGTTTGTGATGAAACTAT

Version 9.2

>lefty.S 9.2 
							CAGATATTTCCGGGGAGATTCTGTACTCAGACTCCAGCAAGCAGTCCCTGGTTTTTGGAATGGAGTCCCGTATCCCAGAGAACAGTGAGGTTACCATGGCTGAACTCAAGCTCTTCAAGAAACCCCCTAAAATCATGAACGTTCCAGAAAGGAGATTCCACCGACCTGTCAACAATGCCAGAGTTAGTGTGTATTATGTGGAGATATTGAAAGATGGCACCAACAGAACCTCCCTGGTGGACTCTAGGTAGGTCATCCAACCCACCAACTGTCACATGCtcattactctgcaaatccaCTCTGTTTCCAGTCAGTGATACTCTGTATTTTCCTGTAATTATAGCCAGATCAGATGAAAGTtataaaaggagtaaaaatagAGAGGCTTATGTGTACATTtatacaaaattaattaattctgTCCTTATCATTTTGCAGATAGaatgtctaaatatataaatttcagTATTGCTCTCAGTATCTGGACCTAACAAAATGTTGATTGTTATGCTGACACTGTGATTCTCTGGACGATTAAAGAACTTGTGTCCCTCCTTATTATTTCCAGGCTTGTGCCAATCATGGAGTCGGGCTGGAGGAGCTTTGACGTGACCCAGGCTGTGCATTACTGGATGAGAAGTGGTGGACAGTCATCAATGCACTTAGAGATCCACGTGGATGGGGAGCGACATGGAAGTCATGCATCTGAGATGGCAAAGATGGTTCGTTTCACCACCCAGAGCCCATCAGACAACTCTCTGGGAAAACCAGAGCTTGTCCTGTTTACTCTCAACCTCAATGAGCAGGGGTAAGTTCCTTCTTAGTTACTACCTTTTTGCCTTGAACTCTCATTGATTTGACATGAGCTGAGGTGTCCAGACTGTTGTCATCCACTCTTGTTGAACAGCACCCCCCAGTGGAGATGCTTAAACAAAGTAGTATCCTGTGCTAAGGGAAACACCATGgcatatgtataaatagaaataaacagaGAATGCTTTGTACACACAATATCAGATAAAAGCACTTCTAAACTGATAGTGAAGTTCTATTATTTATAATTGAATGAAATATGCAAATAGATAAGACTCTCTTTGCAGAATAACTTTAAtaccaatataaaatgtaattgttctaaaccaattttttttctacttacagGACCCGTGGAgactgctcagcatcaggtgccAAGAAAGACAACATCTGCTGCAGAGAGGAATATTTCATTAACTTTCGGGAACTTACCTGGACACAGTACTGGATTATTGAGCCAGCAGGATACAACGCTTTTCGGTGCACTGGAAGTTGCAAGCAACCAAAGTACCCCTTGTCTCATTATCACTATGGACAGAGAACATGCGCCGTGGTGGAAAGCGCCCCACTACCCGTAATGTACCTGGTCAAAAAGGGAGACTACACGGAAATCGAAGTGGCGGAGTTCCCTAATATGATTGTCGAAAAATGCGGTTGCACAATGGACAATATCGCTATCATATGACAGATGGCAGCACTAAGTTCATGCAGATCCGGTGTGTGTAGTACTTGCAAATGTGCTCTTAGTAACCAGGCATGTGTTCAGTGCTGGCAGGGGCCCATTTCGTAAAGTAGGACTGAGCGCCTTTTGGCCTCTACAGCTTTTAAAAGGATGCTGTGAGTTGTACTTTAACAGCAGGGTTGCAGTTTGGGCAAACTGATGTAATGTGCAccctgctgtcaccatcttgccctactgacagGTGTTAGTTACTACTGTAGGTGCTGCCTCAAAGGGATGTGGAGGGCCCAGTGCAGCTGCCCCTGCACTTACCCTGAAGACAGCCCTGTTAGCAACGGAACCGTAAGAATATGGTTTTACCTAGACCAAATCTTACTACTCCTTCTGGGAGTTTGTAAAAGCAGCGACAATTTCCGATCTCAGTAATGTCTGTGGCAGAATGATAGAAGCATTTAGAGAAGCACTTACCTGTAAATAGACTAATATAGATATTTATCTCTCGTTGACTCAGCCACACTGCGGCATGGAGATGgctcataaaatataaatttgacaGAGGTATTTCTATTGGAAGATCatttcagcatattttttaaattctataaatatatatataacggaAACTTTAATCAAACAATAAAGTTTGTGATGAAAATA

CDS

Gene model

Entrez Gene

100170470

373829

398193

mRNA

RefSeq

>NM_001085745|Xenopus laevis left-right determination factor L homeolog (lefty.L), mRNA
								ggcacgagcttgagggaaggaagaagtgatacgcacttgcaccctgtagactgtcacatcagaatgggtgtcactaccaaatctttgaggctctgcttgatcttcagcaccctgtgcctggctgccatcaatggcttcaaccctgacaacatcagagatgctctgctcaaaaaactcaacctccaagaggttcccaaactggagaaaagagacgttgagaacctggtgatccctaggcacatccaagccaaatacatgtctatgctgcacagtcacagagagaggaagaggagatcactgcccagcttggctggcatcctcaggggcatctcaggcaatgcagatatttctggggagattctatactcagactccagcaagcagaccatggtctttggaatggagtcccgtattccagagaacagtgaggtgaccatggctgaactcaagctcttcaagaaaccccctaaaatcatgaacgtcccagagaggagattccaccgaccagtcagcaatgccagagtcagtgtgtattatgtagagatattgaaagatgggaccaacagaacctccctggtggactctaggcttgtgccaattatggagtcaggctggaggagctttgatgtgacccaggctgtgcattactggatgaaaagtggcggacattcatcgatgcacttagagatccacgtggatggtgaacgacatggaagtcatgcatctgagatggcaaaaatggttcgtttcaccacccagagcccatcagacaactctctgggaaaaccagaacttgtcttgttcactctcaaccttgatgagcatggggcccgtggagactgttcagcatcaggtgctaaaaaagacaacatctgctgcagagaggaatatttcattaactttcgggagcttacctggacacagtactggattattgagccagcaggatataatgcttttcggtgcgcaggaagttgcaagcaaccaaagtaccccttgtctcatcactatggagagagaatgtgcgccgtggtggaaagtgccccactgcccgttatgtacctggtcaaaaagggagactacacggaaatcgaagtggcagaattccccaatatgattgtggaaaaatgcggttgcacaatggacaatatcgctataatatgaggaatggcagcactgagttcttgcagatctgctgtgtgtagtacttgcaaatgtgctcttagtaagcaggcatgtctgtagtgctggcaggagcccattatatatagtagaactgtgcaccttttggcctctccagctgtcaaaagggtgctgggagttgtgctttaacagcaactgaagggatgccgtttggccaaacgaatgtaatgtgtgccctactatcaccatcttgccttactgacaagtgttactactataggtgctgctgcacattaaaaaaagttgccttccccagactttatctgcttcaaagggatgtggaaggcacagggcagatgcccctgcttgcacccaccctgatgaacgctctgttagtaactgaaccataaacctatggtttaacctagtgcaaatatcaccgctccttctgggagtttataaaagcaacgacaatttccgatctcagtgatcagaatggcagaatgatagaagcatttagagaagcacttacctgtaaatagactgatatagatatttatctctcgttgacttggccacactgcggcatggagatggctcataaaatatgaatttgacagaggtatttctattggatgatcattgcagcatattttttcaattatatatatatataaagaaaacagaaactttaatcaaacaataaagtttgtgatgaaactaaaaaaaaaaaaaaaaaaaaaa

RefSeq

Protein

NCBI Protein

RefSeq

More..

NCBI Protein

RefSeq

More..

NCBI Protein

RefSeq

More..

Genomic

X. tropicalis

X. laevis.L

X. laevis.S

Genome Browser

(Click image to open in Genome Browser)

Genomic Synteny

Genomicus PANTHER

Expression

Development Stages

Embryonic Tissues

Adult Tissues

Summary for

More Information

Xenbase Expression Details

In situ images

Single cell data at SPRING

Ensembl

Data Mining

X. tropicalis

X. laevis.L

X. laevis.S

XenMine

lefty

lefty.L

lefty.S

Phenotype

X. tropicalis

X. laevis.L

X. laevis.S

Smith Morpholino Screen

lefty-har183

Orthology

Knowledgebases

Entrez Gene

Genetic Phenotypes

Gene Expression

human

Protein Atlas

mouse

rat

zebrafish

chicken

fruit fly

worm

Publications

First

Embryonic asymmetry: left TGFbeta at the right time?, Curr Biol 1997

Most Recent

Chromatin accessibility and histone acetylation in the regulation of competence in early development., Dev Biol 2020

All

View All Papers 17 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology

Functional Ontologies

X. tropicalis

X. laevis.L

X. laevis.S

15 terms

7 terms

PANTHER

lefty

KEGG Pathways

K04668

KOG

Reagents

X. tropicalis

X. laevis.L

X. laevis.S

CRISPRscan Tracks

lefty

Morpholinos

lefty MO1 , lefty MO2 , lefty MO3 , lefty MO4 , lefty MO5 , lefty MO6 , lefty MO7 , lefty MO8

Clones

EXRC Horizon Source BioScience

Horizon Source BioScience

Plasmids

Addgene

Symbol legend:

Blast sequence

View sequence

Literature or expression images

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