Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (6) GO Terms (11) Nucleotides (47) Proteins (20) Interactants (62) Wiki
XB-GENEPAGE-6455903
Gene Symbol:
irs2

Gene Name:
insulin receptor substrate 2

Synonyms:
irsu ( Add synonyms , Nomenclature history )

Gene Function:
RNA polymerase II, large subunit

Protein Function :
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidyl...[+]


InterPro :
IRS PTB , PH domain , PH-like dom sf , IRS

Interactants:
Loading ...

Diseases: 


Disease Ontology:
type 2 diabetes mellitus

OMIM:
TYPE 2 DIABETES MELLITUS; T2D

External Links:
1/3
 
Xenbase Gene ID XB-GENE-6455904 XB-GENE-17346586 XB-GENE-17346587
Gene Symbol irs2 irs2.L irs2.S
Chromosome Chr3 chr3L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 394823
108711802
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein NCBI Protein NCBI Protein  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine irs2 irs2.L irs2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards IRS2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Irs2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Irs2 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR irs2b irs2a ZFIN Ensembl
chicken
GEISHA IRS2 Ensembl
fruit fly
worm
Publications
First Opposite T3 Response of ACTG1-FOS Subnetwork Differentiate Tailfin Fate in Xenopus Tadpole and Post-hatching Axolotl., Front Endocrinol (Lausanne) 2019                
Most Recent Opposite T3 Response of ACTG1-FOS Subnetwork Differentiate Tailfin Fate in Xenopus Tadpole and Post-hatching Axolotl., Front Endocrinol (Lausanne) 2019                
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 2 terms 0 term
PANTHER irs2
KEGG Pathways K16172
KOG [K] RNA polymerase II, large subunit
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks irs2
Clones Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list