Gene Symbol: dlx5 Gene Name: distal-less homeobox 5 Synonyms: dll3, X-dll3 Add Xenopus synonyms Gene Function: homeodomain and LIM zinc binding domain transcription factor Interactants: ss18l1(15) , bmp4(10) , msx1(9) , pax6(9) , dlx3(7) , chrd(6) , sox2(6) View All	1/2

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001004778|Xenopus (Silurana) tropicalis distal-less homeobox 5 (dlx5), mRNA CCAGCCTCCTCCTCCTCTCTCTCTTCCTCCTCCTCCTGCTCAGATCACTAAGGAACCTTCCCAAGCTCTCACTATTTCAGTGCCAGTCCCAGCAGTAGCAGCAGCATGGCCGCCTGAGCAGCTTCCCAGCGCCCCCAATGCAGGCAGATCGCAGTCCCCAGAGCATGACAGGAGTCTATGAGCGGAGAGTCGCCACCATCAGAGCCACTGAGTTCCAGAGCATCATGCACCATCCTTCCCAGGACTCACCAACACTGCCCGAATCCACAGCCACTGACTCTGGCTACTACAGCCCAGGAGGGGCAGCTGGCCACCCACACCATGGCTACTGTTCGCCCACTTCGGCCACTTATGGAAAGGCGCTTAATGCTTATCAGTACCAGTACCATGGCATGAATGGAGCAGCGGGAAACTACCCTGGCAAAGCCTATAGCGATTATGGCTATGGGAGCCCTTACCACCCTCACCACCAGTACAGCGGAGCGTACAACAGGGTGCAGCCCCCCAGCAGTCAGCCAGAAAAAGAAGTATCAGAGCCCGAGGTGAGAATGGTGAATGGGAAACCAAAGAAAATCCGAAAGCCGCGCACCATCTACTCCAGTTTCCAGCTCGCAGCGCTACAGAGGCGCTTCCAGAAGACGCAATACTTAGCGCTGCCGGAGCGCGCAGAACTGGCGGCATCTCTGGGACTAACGCAAACACAGGTAAAAATATGGTTCCAGAATAAAAGATCCAAGATTAAGAAAATCATGAAGAACGGAGAGCTGCCTCCAGAACACAGCCCCAGCTCCAGTGACCCCATGGCGTGTAATTCTCCCCAGTCTCCAGTAGTGTGGGAACCCCAAGGATCTTCAAGGTCACTCAGCCACCACCCCCATGTACATTCCCACCCCCAGGCCTCCGGCAGCTCCCCTGCATCCTCCTATCTGGAGAACTCCAGCGTCTGGTACCCTACAGGCACCCACCTGCAGAACCTGCAGAACCATGCCTCTTTACAGCACCCCTTGGCCTTGGCATCAGGGACTCTCTACTAAAAGACACCCGGGCCGCCTTTTTGTCTTTTTTTGGACTATCATTTTTTTCATTGTTAAGGAGTCATACAAAACAATGCATAACATGGATTTTTTAAGGCAAAGTATATTGTGTAAAGCTTGTTGCATGTAACTTATTGCATTTCAAAGGAGACCGTGTGTTTTTTACAGATTGTCTTTGCGCAACTGGGGACACTATCTCAATGGTGCCTTGAATCTATGACCTCATTTTTTTCCAGAGACTTTTTTTCAATGTTTATTTTAACCATGTAAATACATGTAGATAGAGGAATTAAACTGTATATTCTGGATAAATAAAATTATTTCGACCAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001090564|Xenopus laevis distal-less homeobox 5 (dlx5), mRNA GCAGCAGCAGCAGCAGCATGGCCGCCTGATCAGCTTCCCAGAGCCCCCAATGCAGCCAGAGCGCAGCCCCCAGAGCATGACAGGAGTCTATGAGCGGAGAGTCGCCTCCATCCGAGCCAGTGAGTTCCAGAGCATGATGCACCACCCTTCCCAGGATTCCCCCACTCTGCCCGAATCCACGGCCACTGACTCTGGCTACTACAGCCCGGGAGCAGCCGCTGGCCACCCTCACCATGGCTACTGTTCGCCCACTACGGCCACTTATGGAAAGGCGCTGAATGCGTATCAGTACCAGTACCATGGCATGAATGGAGCAGCTGCAAACTACTCTGGCAAAGCCTACAGCGACTATGGCTATGGGAGCCCTTACCACCCTCACCACCAGTACAGCGGAGCGTATAACAGGGTGCAGCCCCCCAGCACTCAGCCAGAGAAAGAAGTATCAGAGCCCGAGGTGAGAATGGTAAATGGAAAACCGAAGAAAATCCGAAAACCGCGCACCATCTACTCCAGCTTTCAACTCGCAGCATTACAAAGACGCTTCCAGAAGACGCAGTACTTGGCGCTGCCGGAACGCGCAGAACTGGCGGCATCGCTGGGACTAACGCAAACACAGGTAAAAATATGGTTTCAGAATAAAAGATCCAAAATTAAGAAAATCATGAAGAACGGAGAGCTGCCTCCAGAACACAGTCCCAGTTCCAGTGACCCCATGGCGTGTAATTCTCCCCAGTCTCCAGTGGTGTGGGAACCCCAAGGATCCTCAAGGTCACTCAGCCACCACCCCCATGTACATTCCCACCCCCAGCCCTCCAGCAGCTCCCCTGCATCCTCCTATCTGGAGAACTCGGGCGTCTGGTACCCTACAGGCACCCACCTGCAGAACCATGCCTCTTTACAGCACCCCTTGGCCTTGGCATCAGGGACTCTCTACTAAAAGCCACCTGGGCTTCTTTTTGTCTTTTTATTTTTGGACTATCATTTTTTCATTGTTAAGGAGTCATACAAACCAATGCATAAGATGGATTTTTTTTAAGGCAAAGTATATTGTGTAAAGCTTGTTGCATGTAACTTATTGCATTTCAAAGGAGACCGTGTGTTTTTTACAGATTGTCTTTGCGCAACTGGGGACACTATCTCAATGGTGCCTTGAATCTATGACCTCATTTTTTTCCAGAGACTTTTTTTTCAATGTTTATTTTAACCGTGTAAATACATGTAGATAGAGGAATTAAACTGTATATTCTGGATAAATAAAATTATTTCGACCAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001004778|distal-less homeobox 5 [Xenopus (Silurana) tropicalis] MTGVYERRVATIRATEFQSIMHHPSQDSPTLPESTATDSGYYSPGGAAGHPHHGYCSPTSATYGKALNAYQYQYHGMNGAAGNYPGKAYSDYGYGSPYHPHHQYSGAYNRVQPPSSQPEKEVSEPEVRMVNGKPKKIRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGELPPEHSPSSSDPMACNSPQSPVVWEPQGSSRSLSHHPHVHSHPQASGSSPASSYLENSSVWYPTGTHLQNLQNHASLQHPLALASGTLY	Refseq >NP_001084033|homeobox protein DLL-3 [Xenopus laevis] MTGVYERRVASIRASEFQSMMHHPSQDSPTLPESTATDSGYYSPGAAAGHPHHGYCSPTTATYGKALNAYQYQYHGMNGAAANYSGKAYSDYGYGSPYHPHHQYSGAYNRVQPPSTQPEKEVSEPEVRMVNGKPKKIRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGELPPEHSPSSSDPMACNSPQSPVVWEPQGSSRSLSHHPHVHSHPQPSSSSPASSYLENSGVWYPTGTHLQNHASLQHPLALASGTLY UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.11087	Xl.18401 [+] Xl.59391
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		22 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	DLX5
mouse		MGI	Dlx5	All(6) Targeted, knock Out(1) Targeted, other(5)
zebrafish		ZFIN	dlx5a	3 Lines(s)

Publications
First:		Xenopus Distal-less related homeobox genes are expressed in the developing forebrain and are induced by planar signals. [Development 1993]
Most recent:		Induction of the neural crest state: control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions. [Dev Biol 2012]
		View All Papers 3 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains

Reagents		tropicalis	laevis
Clones		EXRC - 1 clone(s)	EXRC - 2 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.11087.1.S1_at [+] Str.26629.1.A1_at	Xl.18401.1.S1_at
Affymetrix 2.0			Xl2.18401.1.S1_at

Symbol legend[+]

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