Gene Symbol: en2 Gene Name: engrailed homeobox 2 Synonyms: engrailed homolog 2, En-2, engrailed-2, engrailed 2, eng2, xen2, maben Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: egr2(72) , otx2(68) , t(30) , ss18l1(29) , chrd(28) , nog(28) , hoxb9(26) View All	1/3

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		NCBI Nucleotide >XM_002932479|PREDICTED: Xenopus (Silurana) tropicalis homeobox protein engrailed-2-A-like (LOC100498251), mRNA ATGGAAGAGAATGAGCAGAATAACAGGGAAGTGGAACCGCAGGAGTCGGGAGATGAGTCCAACAGGGGGATCCTTCATCAGGCTCCTCCTGGGAACCACCAGCCCCACCACAGGATAACCAACTTCTTCATTGACAACATCCTACGGCCGGAGTTCGGGAGGAGGAAAGAAGGAATAAGCCATCAGGATGAGCTCTTTTCTGGCAGAGACAGTGGGGCTTTGTCTGGGGCAGAGAGCGCCCACCATAGAGCCAATGCCACCGAGGGCGCAGGGGGCTCCAAAGCCATCACTCTTACTGGGGATAAGAAAAGTGACATAGCCATGGAAGAAAGCTTAAAATCCAGAGGGCATAATGGAGACCATTCCCTCAGCTCAGACTCTGACAGTTCCCAAGCCAGCTCCAAAACCTCTCAGCAGCCCATGTTGTGGCCAGCCTGGGTCTACTGCACCAGGTATTCAGACAGACCTTCATCAGGTCCCAGATCCCGCAAACCAAAGAAGAAGACGACGACGACTGTCACTAAAGAGGACAAAAGGCCCCGAACTGCCTTCACTGCCGACCAGCTTCAGAGGCTCAAGGCCGAGTTCCAAACAAACAGGTATTTGACTGAGCAGAGGAGGCAAAGTTTGGCTCAGGAACTCAGTCTTAACGAATCTCAAATCAAGATCTGGTTTCAGAATAAACGAGCAAAGATTAAGAAAGCCACGGGGAACAAAAATTCCCTGGCCTTGCATCTAATGGCTCAAGGACTTTACAACCATTCGACCACTTCAAAGGACAGCAAATCAGACAGCGAATAGTAGCGGTTCGGTAACGCAAAGGCCTTGCAATGCAATAATTTAATGGGGAAATAAAGGGCCATTGTACAAAGAATATACCAGCATTTGGCTTCGGAGTGTGGGATAAATCCGCAATATTCTATGTAAATATAATTTACAGGCAAAAACAAACACAAGAAAAACATAAAATCGAAACTATGGACACAACTCTTTTTGCTTTGATTTAATTATTATTTTATTTTTTTAATTTTAGAGCCTATCCTTTACCAATCATTTTTCTGCTTAGATTTTATTTTATACTAAGCGA	Refseq >NM_001101743|Xenopus laevis engrailed homeobox 2 (en2-a), mRNA GGAGCGTGTAAAAATTGGTCTCTCTTAGGAGACAGCTCTGGAAGCGCCGTGGGTTCATGTGCTGCTCCTCCTGCTGTAACAAGAGTGGGGCAGCTCCTATAGACTTTATTTTTAATAATTATATATCTTATATACATATATCTTATGTCACACTCCCTCAGCTCCACCACTGGGGCTTGGATGGTCTACAAACATCTCCCTACTGGCTGCTCTCAAGGATTTCCCCCCCAGGAACCTGGATCTGGAAGGAGGGGGTAATGAGCCCGTCCTGGGGAAGAAGAAGGAGAAGATGCTTTGCTTGGCTGAAGTGAAACATTAAAATCTGCAGAGAAACCGAGAGAGAGCAAAAAAAGAGGAGGCAGAACCTTTCCTGCAGGAACGTCCCTGGGTCAGAGGCAATTTGAATGTGTAGCTGACTGGAGCCTGTAGGAAACACAAGGGGTTAAAGGCAAGAAGAAGCTTTGGAATAACAGCATGGAAGAGAATGAGCAGAATAACAGGGAAGTGGAGCCACAGCAGGAGTCAGGAGAAGAGTCCAACAGGGGGATCCTTCATCAGGCTCCTCCTGGGAACCACCAGCCCCATCACAGGATAACGAACTTCTTCATTGACAACATTCTACGGCCGGAGTTCGGGAGGAGGAAAGAAGGAATAAGCCATCAGGATGAGCTCTATACTGAGAGAGACACTGGGGCTTTGTCTGGGGCAGAAAGCGGCCACCACCGAGTCAATGTCCCCGAGGGCGCAGGAGGCTCTTCCAAAGTCATCACTGTTACTGGAGAGAAGAAAAGTGACCTGGCCATGGAAGAAACCCTGAAATCCAGAGGACTTAATGGAGACCATTCCCTCAGCTCAGACTCTGATAGTTCCCAAACCAGCTCCAAAGCCACTCAACAGCCCATGTTGTGGCCAGCCTGGGTCTACTGCACCAGATATTCAGACAGACCTTCATCAGGTCCGAGATCCCGCAAACCAAAGAAGAAGAGTGTCAGTAAAGAGGACAAGAGGCCCAGAACTGCCTTCACTGCTGATCAGCTCCAGAGGCTCAAGGCCGAGTTCCAAACAAACAGGTATTTGACTGAGCAGAGGAGGCAAAGTTTGGCTCAGGAACTCAGTCTTAACGAATCTCAAATCAAGATCTGGTTTCAGAATAAAAGAGCAAAGATTAAAAAAGCAACAGGGAACAAAAATTCATTGGCCCTGCATTTAATGGCTCAAGGACTTTACAACCACTCAACCACTTCAAAGGACGGCAAATCAGACAGCGAATAGTAACGTTTCGGTAACGCGAAGGCCTCGCAATGCAATAATTTAAGGAAGAATAAAGGGCCAGTGTATAAAGATTAAACCAGCATTTGGCTTTGGAGTGTGTGTGTTGGGATAAATCCGCAATATTCTATGTAAATATAATTTACAGGCAAAAACAAACAAAAAAAAAAAAAAACGGAATTC		Refseq >NM_001101791|Xenopus laevis engrailed homeobox 2 (en2-b), mRNA GCTCTGGAAGCGCAGGGGATTGATGTGCTGCTCCTCCTGCTGTGCAGATGTTACAGTGATATAGACTGTACATGTAATATCTTTCTATTATTTTATATCTATTATATGTCACACTTGCTGAGCTCCACCACTGGGACTTGGATGGGGCTACAAACATCTCCCTGCTGGCTACTCTGAAGGATTTCTCCCCAGGAGTCTGGATCTGGAAGGAGGGGGGTAATGAGCCCGTCCTGGGGAAGAAGAAGAAGAAGATGCTGTGGTTGGCAGAAGTGAAACATTAAAAATCTGCAGAGGAACCAACAGAGGAACCAAGAGAACAAGAAGAAGGGTCAAAGCCTTTCTGCTGGAACGTCTGTCGGAGCCTTGGGGTTAGAGGCAATTTGAATGTGTAGCTGACTGGAGCCAGTAGGAAACACAAGGGGTTAAAGGCAAGAAGAAGCTTTGGGGAACAGCATGGAAGAGAATGAGCAGAATAACAGGGAAGTGGAACCGCAGCAGGAGTCAGGAGAAGAGTCCAACAGGGGGATCCTTCATCAGGCTCCTCCTGGGAACCACCAGCCCCATCACAGGATAACTAACTTCTTCATTGACAACATCCTACGGCCGGAGTTCGGGAGGAGAAAAGAAAGAATAAACCACCAGGATGAGCTCTTTACTGGGAGAGACACTGGGGCTTTGTCTGGGGCAGAGAGCGGCCACCACCGAGTCAATGTCCCCGAGGGCGCAGGAGGCTCTTCCAAAGTCATCACTGTTACTGGAGAGAAGAAAAGTGATCTAGCGATGGAAGAAACCTTAAAATCCAGAGGACTTAATGGAGACCATTCCCTCAGCTCAGACTCTGATAGTTCCCAAGCCAGCTCCAAAGCCACTCAAAAGCCTATACTGTGGCCAGCCTGGGTCTACTGCACCAGATATTCAGACAGACCTTCATCAGGTCCGAGATCCCGAAAACCAAAGAAGAAGAGTGTCAGCAAAGAGGACAAGAGGCCCAGAACTGCCTTCACTGCTGAACAGCTTCAGAGGCTCAAGGCCGAGTTCCAAACTAACAGGTATTTGACTGAGCAGAGGAGGCAAAGTCTGGCCCAGGAACTCGGTCTGAACGAATCTCAGATCAAAATCTGGTTTCAGAATAAACGAGCAAAGATTAAAAAATCCACAGGGAACAAAAATTCCCTGGCCCTGCATTTAATGGCCCAAGGACTTTACAACCACGCGACCACTTCAAAGGACGGCAAATCAGACAGCGAATAGTAACGTTTCGGTAGCGCAAAGGCCTCGCAATGCAATAAAAAAGCCTGTGTATAAAGAATCTACCAGCATTTGGCTTCGGAGTGTGTTTATTGGGATAAACCCGCAATATTCTATGTAAATATCATTTACAGACAAACAAACAAAAGGAAAAAGTCGAAAATATGGACACAACTATTTTTTCTTTGATTTCATTATTATTTTATTTTGTTTAATCCTTTCCAGTCCTTTTTTTTCCTGCCTTTAGATTTTATTTTATACTAAACGATGCTCGTGGATGTCGGAGAGAAAAAAAAAATCAAAAAAAGTCAACCTTTTTTTTTTTTTTTGCTAAAGTGGAAAGATGAAATTGCTGCATTTCGCACTACTGTGAATTTAATTAAAAAAAAAAAAAGCTAATATTTGTTGTGTTTTTTTTTGTTTTTGTTAATATTTGAAACTTTTTGTTGTAAAATAAATCAAAGCAGGGGCCATGTCCTGTCGCTGTTGTAATTAAAGGTGTATTTTAATTGATTTAATTTTTTTGTTTTTATATGCATTTTTTTTATAGTTGTGCAGAATATGATTTATTTATATACACTGGCGGGGTGATTTATAGTTTTGCACTTAGTGTTTTTTTTTTAAATGACATATTGGGGCAACTTTTTTCTTTAAAATGACATATTGGGCAACTTTTTTTTTTTTTGCTGACAAATTGTATTATTTCCCAGAAATTGAAGATATTGAAGCCTGACAGCTGCATATGTACTAGGAACAAGCAAACCAAACATTTGCCAATCACTGTCCCAATAAATGGTTAATTTATCCAATCCACTTTCCCCTCCTACTATGACGTAATCCCCCCTTCCCCACTCTGCTGCACCCCCCTTCCCTGTTTATGGATCCCTCCTTTGTTTCCAACTTCCCTGAATTTTAAAAAAAGACCCTGCAAAAATAATACATGAGCCCAATGAATAATGGAGAGGTTTATAATGAATCAGGTCAATGGACTACAGCTGATTTGGGCCATTTCTTTTGTTACAGTTCATTTTTTTTTTAAAGATATTAAAGTTTTTTTTGTTTTTTAAATCAATCACCGATTTCATCGTAAAGAATGTAATATTTAGCCTTGGACAGAAGTAAAACTTAAAAATCATGCAAAAGAACCTCTTTTCTCCAATTCTAGGGGAACTTACTACATTTATTCTCTTACTGTATATGTACCATTTGCCTTCTTTTAATTGATTTTTTTTTTTTTAAATTAAAAAACATAAAAAGGAAAAAAAAAAATCTGGCAAGACAAAGCCAGAAATCTAATGATACAATTAGTGTAAATACAATGTTTCCAACACTGGCAATGTTTGTTTTCATTTGAATGTACAGAGATGCAAATAATAAATATTTCCCCCTTTCTGATTTTAAAAATAAACCGGAATTCC
Protein		NCBI Protein >XP_002932525|PREDICTED: homeobox protein engrailed-2-A-like [Xenopus (Silurana) tropicalis] MEENEQNNREVEPQESGDESNRGILHQAPPGNHQPHHRITNFFIDNILRPEFGRRKEGISHQDELFSGRDSGALSGAESAHHRANATEGAGGSKAITLTGDKKSDIAMEESLKSRGHNGDHSLSSDSDSSQASSKTSQQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKTTTTVTKEDKRPRTAFTADQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNSLALHLMAQGLYNHSTTSKDSKSDSE	Refseq >NP_001095213|homeobox protein engrailed-2-A [Xenopus laevis] MEENEQNNREVEPQQESGEESNRGILHQAPPGNHQPHHRITNFFIDNILRPEFGRRKEGISHQDELYTERDTGALSGAESGHHRVNVPEGAGGSSKVITVTGEKKSDLAMEETLKSRGLNGDHSLSSDSDSSQTSSKATQQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKSVSKEDKRPRTAFTADQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNSLALHLMAQGLYNHSTTSKDGKSDSE UniProtKB		Refseq >NP_001095261|homeobox protein engrailed-2-B [Xenopus laevis] MEENEQNNREVEPQQESGEESNRGILHQAPPGNHQPHHRITNFFIDNILRPEFGRRKERINHQDELFTGRDTGALSGAESGHHRVNVPEGAGGSSKVITVTGEKKSDLAMEETLKSRGLNGDHSLSSDSDSSQASSKATQKPILWPAWVYCTRYSDRPSSGPRSRKPKKKSVSKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELGLNESQIKIWFQNKRAKIKKSTGNKNSLALHLMAQGLYNHATTSKDGKSDSE UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene			Xl.1173		Xl.1174
Unigene EST Profile			EST Profile		EST Profile
GEO data			GEO		GEO
Images		114 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	EN2	OMIM:611016
mouse		MGI	En2	All(11) Targeted, knock Out(6) Targeted, other(5)
zebrafish		ZFIN ZFIN	eng2a eng2b	1 Lines(s)

Publications
First:		Expression of an engrailed-related protein is induced in the anterior neural ectoderm of early Xenopus embryos. [Development 1989]
Most recent:		The XenopusTGFBI is required for embryogenesis throughregulation of canonical Wnt signalling. [Dev Biol 2013]
		View All Papers 40 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		multicellular organismal development regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[R] Transcription factor Engrailed, contains HOX domain

Reagents		tropicalis	laevis a		laevis b
Clones			EXRC - 1 clone(s)
			open biosystems		open biosystems
			geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		StrEns.988.1.S1_at	Xl.1173.1.S1_at		Xl.1174.1.S1_at
Affymetrix 2.0			Xl2.1173.1.S1_at		Xl2.1174.1.S1_at

Symbol legend[+]

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