Gene Symbol: tcf7 Gene Name: transcription factor 7 (T-cell specific, HMG-box) Synonyms: tcf1, Xtcf1, Xtcf-1, tcf-1 Add Xenopus synonyms Gene Function: high mobility group transcription factor Interactants: lef1(11) , tcf4(9) , tcf3(8) , tcf7l1(6) , tle4(6) , sia1(5) , ctnnb1(4) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_204090|Xenopus (Silurana) tropicalis transcription factor 7 (T-cell specific, HMG-box) (tcf7), mRNA ATGCCCCAAATGAACAGCGCCGGCGAAGATGACTTGGGGGCCAGCGATGAAATGATTTCCTTCAAGGACGAAGGGGACCAGGAAGAAAAGATACGGGAAAGCGCCTTTACCGAGAGGGATCTGGCAGATCTGAAGTCATCGCTCGTAAACGAGTCCGAAGTCAGCTCGCATCCCCGTGTCCCGGAGAGTCATCCCGAGGCGATGAGGCGCACACAGGATGCCCAGCTAGTGTATCAGGACAAACTCACAGATCACATGGAAGATGGTGTTAAGCACCAAGACGAAGGTATGTACAAAGGATCTGGATATCCCAGCTACCCATTCCTTATGTTATCGGATCCCTACCTTTCCAACGGATCTGTGTCAGCACTGTCCAGCAAAGTTCCTGTGGTACAACCATCACACGGAGTTCATCCTCTCATTCCCTATAATAACGAGTCCTTCAGCCATGGCTCCCATTCTACACACCTTCCCGCCGATCTGAATCAGAAGCAAGGTGTGCATAGACCTGCCCAAACAGCTGATATCCCCACCTTCTACCCTTTGCCTTCTGGAGGAGTTGGACAGATATCCCCTTCAGTGGGGTGGTTTCCTCATCCTCTGATGCTGAGCCCCAGCATGCACACGACCGGGATTCCTCACCCAGCAATAATACCGCATTCAGGAAATAAAGACATAGACTGCTATGAAAGAAATATGAAACCACATTCTGAGCCAAAGAGAGAAAGAGAGCCCAAGAAACCTACTATTAAGAAACCATTAAATGCCTTTATGCTGTACATGAAAGAAATGAGAGCAAAAGTGATTGCAGAATGCACGCTAAAAGAGAGTGCAGCCATTAATCAGATCCTAGGGAGAAGGTGGCATGCATTGTCCAGAGAAAAACAATCAAAATACTATGAACTGGCCAGAAAAGAGAGGCAGCTACACATGCAGTTATACCCAGGGTGGTCTGCAAGAGATAACTATGGAAAAAGAAAGAGAAGAACCAGAGAAAAACACCAGGATTCTAGTTCAGACCCTGGCTCCCCTAAGAAATGCAGAGCTCGCTTTGGCCTCAACCAACAAACAGACTGGTGCGGTCCATGCAGATAA	Refseq >NM_001089222|Xenopus laevis transcription factor 7 (T-cell specific, HMG-box) (tcf7), mRNA AGCCTCCCCACAACTTTCTCATGCTGCACCGCCGGCCGTGACTTCCAGCAGCCTCTTAGTCTTAGCACTGCCTCCCCCTTCCCCTTCACACACCCAGAGAAATGCCCCAAATGAACAGCGCCGGGGAGGATGACTTGGGCGCCAGCGATGAAATGATCTCGTTTAAGGATGAAGGGGACCAGGAAGAAAAGATACGGGAGAACGGCTTTACCGAGAGGGACCTGGCTGATCTCAAGTCGTCGCTCGTCAACGAGTCCGAAGTCGCCTCACATCCCCGAGTCCCTGAAACTCACCCCGAGGCGATCCGTCGCGCACAGGATGTCCAGCTGGTGTATCAGGACAAATTCTCCGCTCACATGGAAGATGGTATTAAACACCAAGACGAAGGTATGTACAAAGGATCTGGATATCCCGGCTACCCATTCCTTATGTTATCGGATCCCTACCTTTCCAACGGATCTGTGTCGGCGCTGTCCAACAAAGTTCCTGTGGTACAGCCGTCACATGGTGTTCATCCTCTCATTCCCTATAATAGCGAGTCCTTCAGCCATGGCTCCCATTCTCCACACCTTCCTGTCGATCTGAATCAGAAGCAAGGTGTCCACAGACCTTCCCAAACACCTGATGTTCCCACCTTCTACCCCTTGCCTTCTGGAGGAGTTGGACAGATATCCCCTTCCATGGGGTGGCAAAGCCAGCCTGTCTATCCTATCCCTTCTTGTGGGTTTAGACAGCCATACTCGGCGACAATGTCCTCCGGCCCTTCCTATTCCAGGTTTCCTCATCCTCTGATGCTCAGCCCCAGCATGCACACAACAGGGATTCCTCACCCAGCCATAATACCCCACTCAGGAAATAAAGACATGGACATCTACGAAAGAAATATGAAGCAACATTCAGAGCCAAAGAGAGAAAAAGAGCCCAAGAAACCTGCTATTAAGAAACCATTAAATGCCTTTATGCTCTACATGAAAGAAATGAGGGCAAATGTTATTGCAGAATGCACGCTAAAAGAAAGCGCAGCCATTAATCAGATCCTAGGGAGAAGGTGGCATGCATTGTCCAGAGAAGAACAATCAAAATACTATGAATTGGCCAGAAAAGAGAGGCAGTTACACATGCAGTTATACCCAGGCTGGTCTGCAAGAGACAACTATGTAGGGAAAAAGAAAGAGAAGAACCAGAGAAAAGCACCAGGATTCCAGTTCAGGAGGAAAAAGAAGTGCATTCGGTACTTACAAGGAGAAGGACGATGTGGCAGCCCAGTTTCTTCCGATGGAAGTGCTATAGACTCTCCTCCTTCTCCAATAAATTCACTGCAATGCCTACCATCTTCTGCTTATCCTTCAGCCAAGCTTTCTAGCCCTGCTGATACTGCAGAAAGTGCTCAGACTTTCTCTCCATCTTCATCTAGCACGGCCAGATCCAGCCTTGTATCCGCAGGATATAAGGGAGCATTCTTGTCCGAAACTGTCAATGCATCTAAAAACTCTTGAATTCGGGACCCACTTTAAAATACTGTAGCACCATCTTGGTCACAGTAACTGTTTTTAATGCTTCATTGGACATTTTGTAACTGCTCTTACACTTTTCTGTAGCTTCTGAGGGCTCCTCGGTTATGGTTTGTAAGCTCAAGACTTGGGAAAACGTTGCATTGTTGCCCAATCATTTGGACTTTTTATAGAGCTTCATCATTTTCTTTCTCCCCTGTTCGCCTTGGAAAGCTTTGGCTTTATACATACTGTTTGCAACCCCTGCAACATATCTTAGTGCACAATATTTTTTATTGCTTCCTATTGTACGTTATTTTGCAGTAATGTTTACCCAAGTCTATAACAAAATCATAAGAACTAGATAAAAAAATCCACCCAAAACCTAGCACTTGAAATGTATGTGACGGCAACATACCGCAGCTTTAGAACAGGAATTGGTCGGAAAGCAGATCTAGAGGAGCTACAAGATTTTTTTACCGAGGCAGAGGGCTATTTTGGCACCAGTTCTTAACTTTTTCCCTTTTAAACTTTTGTTAGAGGCCAGGCAAAGGGCCTCATTCAGTCTCCTGTTAATAAGATTCTACAGAGATTAGATACCACTGAATTTCACCTTTGAATATTGTACACCAACCGAATGCAAAAAAAAAAAAAATATATAGAAAATAAAATACAAAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_989421|T cell-specific transcription factor 1, isoform C [Xenopus (Silurana) tropicalis] MPQMNSAGEDDLGASDEMISFKDEGDQEEKIRESAFTERDLADLKSSLVNESEVSSHPRVPESHPEAMRRTQDAQLVYQDKLTDHMEDGVKHQDEGMYKGSGYPSYPFLMLSDPYLSNGSVSALSSKVPVVQPSHGVHPLIPYNNESFSHGSHSTHLPADLNQKQGVHRPAQTADIPTFYPLPSGGVGQISPSVGWFPHPLMLSPSMHTTGIPHPAIIPHSGNKDIDCYERNMKPHSEPKREREPKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREKQSKYYELARKERQLHMQLYPGWSARDNYGKRKRRTREKHQDSSSDPGSPKKCRARFGLNQQTDWCGPCR	Refseq >NP_001082691|T cell-specific transcription factor 1, isoform C [Xenopus laevis] MPQMNSAGEDDLGASDEMISFKDEGDQEEKIRENGFTERDLADLKSSLVNESEVASHPRVPETHPEAIRRAQDVQLVYQDKFSAHMEDGIKHQDEGMYKGSGYPGYPFLMLSDPYLSNGSVSALSNKVPVVQPSHGVHPLIPYNSESFSHGSHSPHLPVDLNQKQGVHRPSQTPDVPTFYPLPSGGVGQISPSMGWQSQPVYPIPSCGFRQPYSATMSSGPSYSRFPHPLMLSPSMHTTGIPHPAIIPHSGNKDMDIYERNMKQHSEPKREKEPKKPAIKKPLNAFMLYMKEMRANVIAECTLKESAAINQILGRRWHALSREEQSKYYELARKERQLHMQLYPGWSARDNYVGKKKEKNQRKAPGFQFRRKKKCIRYLQGEGRCGSPVSSDGSAIDSPPSPINSLQCLPSSAYPSAKLSSPADTAESAQTFSPSSSSTARSSLVSAGYKGAFLSETVNASKNS

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.8106 [+] Str.78972	Xl.3962
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		2 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	TCF7
mouse		MGI	Tcf7	All(6) Targeted, knock Out(3) Targeted, other(3)
zebrafish		ZFIN	tcf7	7 Lines(s)

Publications
First:		XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. [Cell 1996]
Most recent:		The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation. [Int J Dev Biol 2013]
		View All Papers 5 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding
Biological:		regulation of transcription, DNA-dependent
Cellular Component:
EC:
KOG:		[K] Transcription factor TCF-4

Reagents		tropicalis	laevis
Clones			EXRC - 4 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.8106.1.S1_at	Xl.3962.1.A1_at
Affymetrix 2.0			Xl2.3962.1.S1_at [+] Xl2.3962.2.S1_a_at

Symbol legend[+]

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