Gene Symbol: gbx2.1 Gene Name: gastrulation brain homeobox 2, gene 1 Synonyms: XGBX-2 Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: gbx2.2(14) , otx2(10) , en2(9) , egr2(5) , fgf8(5) , snai2(5) , pax2(4) View All	1/2

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002932000|PREDICTED: Xenopus (Silurana) tropicalis homeobox protein GBX-2-like, transcript variant 1 (LOC100485559), mRNA GGGGAGAGAAGAAGCTGCACATCCAGGTCACCAAGGAAGAGAGGAGATCCCATTACACCGACTGCAATTGACAAGGTCCCACCAAACAGACAGGAGCACGGATCTAACAGTACAGGCAGAGAGGAGAGACCCCATTTCTGCGGGAAGAATCCCAAACACAGAAGGAGAAAGTCCCCAGAAAGCAGAAAGTGGGAGCTGTGCGTGCAGGGCACCCAGAAAGGAGCACCCAGGAAAGCAAAGCAAAATCGTCACTCAGAGAGAGAAATGGCCCTCAGCACCCAGTGAAGAAGCAACACAGCCAGGAAACTGGAAGGGGTGAAGTGATTCCTTCAGAGGAGACAATTCCCATATAGAGAGGCTGTGTACTCAGGGCATCCAATAAGAGAGGGGTACTAGAGAGACCCCCCACTATACAGAGAGGGACTCACATAAGCCTGGCGCACATAAAGCTGTCACCAAAGAATCTCCAGAGAGCAGTGGGAGGCCCTCCTTTACTTAATGAAGGTTTAGTCTGTGACCCATACAGAATACTGCTTTGTATATCTGGCTTTGGCACCCATCACCCACTTCTACCCAAATCACTGGCACTCTACCAATGGTAACTGTGGCAGACTGTGGCTCTGGTGCCTGCTGAGAGCTGCTCTAGTTGTTTGTGCCCAACTTTGGGAGCATTTTCTTAGCCTTCCTTTGACTCCCAGTAGCTTATATGAGTGCAGCCTTTCAGCCCCCTCTCATGATGATGCAGCGTCCCCTGGGCAGCAGTACAGCCTTTAGTATAGACTCACTGATAGGGAGCCCACCACAACCCAGCCCTGGACATTTTGTGTACACCGGATACCCCATGTTCATGCCTTACCGGCCTGTGGTCTTGCCCCCTCCACCACCCCCTCCTCCATCTCTGTCTCAAGCCACTCTGCAGCCAACTCTCCCTTCAGCGCATCCCCACCACCAGATCCCCAGCCTGCCCAGTGGATTCTGTTCCAGCCTTGCCCAGGGCATGGCACTTACCTCTACCCTCATGGCTACTCTGCCAGGGGGATTCTCAGCCTCCGCCCAGCACCAGGAGGCAGCCAGAAAGTTTGGAGCTCAAAGTCTCCAGGGGGCCTTTGAAAAAAGCGACGGGGGTCAGTCAGATGGAGAAGATGGTAACAAGACCTACATAACCAAAGAGGGCACCTTACTGCCTTTCTCTGCTTCGGAAGTTTCTCTGGGTCCAGTCCGTGGGCAGGGGAAAGAGGAGTCTGGGAAAGAAGCAGAAGGAAAGGGCAAGGAGGATTCCTACCTGATGGACAGTGACCTGGACTACAGTTCAGATGACAATATCTCCTGCCAAACTGCACACAAAGAGGACGACACCCCAGAGGAAAGCCCCCCAAACTCAAATCCTTCTAATAACAGCAACACCAGCTCCACGGGGAAGAACCGACGGAGGAGGACTGCCTTCACCAGTGAACAACTGCTGGAACTAGAGAAAGAGTTCCACTGCAAGAAGTACTTGTCCCTGACAGAGAGATCCCAGATCGCACATGCGCTCAAACTCAGCGAGGTCCAGGTCAAAATCTGGTTCCAGAACCGCAGAGCCAAGTGGAAGAGGGTCAAGGCTGGTAATGCGAACTCCAAAACTGGGGAGCCCTCTAGAAACCCCAAAATTGTTGTGCCCATCCCAGTCCATGTCAGTAGGTTTGCCATACGGAGCCAACACCAGCAGCTGGAGCAAGCAAGACCTTGAAATGGGCAATGGACATCAGCAGAGAAATCCATTTTGTGGCCCTCCAGTTGTTAATCTACATCTACCAGTATCCCCTGACAGCCAAGGGCAATTAGAGGGTGGTGGAAGTTGTAGTTTTACAACAACGATAGGGCCATAATCTGGTCATCCCCGGACAATGAACAGATTAGCCATGGGTCAGACAATGGAGGTCACAGGACGTCAATAACCAATTCCCTCCTAGACTTTCCAGAAAGACCCCAGTACTTATTATGTTAAGAAGAAGGGGTGATTTTTGCACTTGGGGTGGCTAAAAGGTTAGTTCTTCAGGAACTTAATTTTATGTACAGATAGATGGAAGCTGGCCTCTTTTTAGGGGTGGTGGACAAAACCCTCTCAAAGCCGTCTTAATTCTAATGTTCTGGACTTTCTATGGACAGAGGCTTAGTGAGAGCTCTGGAACCGGCCACAGGGTTGCGTTGCCTGAAAAGTGCTGTGGGAGCAAAGTTACTTCGGTACGACTGAGGGGGGTACATGCCGAAAAGATGGTAACATCTTCCCCCCCCCCTGCCCTGGGGTGCAATCCCCTTAAACAAACTGAACATGTTTTCTAAATTCTCCCAGAGCCTCAGATTATGTTGTGGTTAATTTATTCTGTGTTGCTTATTTCTTATAAGTTATAAAACTTAAAAAACTCAGTCTTGTGAAATCCAATCATGTCTCTAATAAATAATTCCTTGCAGCC	Refseq >NM_001090431|Xenopus laevis gastrulation brain homeobox 2, gene 1 (gbx2.1), mRNA GGGAGAGAAGAAGCTGCACATCCAGGTCACCAAGGAAGAGAGAAGATCCCACCACACCGACTGCAAGTGGCAAAGCCCCGCCAAACACACAGGAACAAGGATCTGACAGTACAGACAGAGAGGAAAGTCCCCATTTCTGCTGGAAGAATCCCAACCACAGAAGGAGAGAGTCCACAGAAAGTATAAAGTGATAGCTGCGAGTGCAGGTCGGCCAAAAAGGAGAGAGAGAAAAGAAGGAAAGAGAAGGAAATCGTAACTGCAAGGGGCAAAGTGAGACAATTCAGAGGAGACAATCCCTGTGTGACCCACACAGAACACTGCTTTGTATATCGGACTTTGGCATCCATCACCCACTTCTACCCTATTGCTGGCACTCTATCAATGGTCACTGTGACAGACTGTGGCTCTGGTGCCTACTGAGGGCTGTTCTAGTTGTTTGTGCCCAACTTTGGGAGAATTTTTTAGGCTTTCTTTGACTCCCAGTAGCTTATATGAGTGCAGCCTTTCAGCCCCCTCTCATGATGATGCAGCGTCCCCTGGGCAGCAGTACAGCCTTTAGTATAGACTCGCTGATAGGGAGTCCACCACAGCCCAGTCCAGGACATTTTGTATATACTGGATACCCCATGTTCATGCCTTACCGGCCTGTGGTCTTGCCACCGCCACCACCCCCTCCTCCATCTCTGTCTCAAGCCACTCTCCCTTCAGCGCACCCTCACCACCAGATCCCCAGCCTGCCCAGTGGATTCTGTTCTAGTCTTGCCCAGGGCATGGCACTCACCTCTACTCTCATGGCTACGCTGCCAGGGGGATTCTCAGCCTCCACCCAGCACCAAGAGGCAGCCAGAAAGTTTGGAGCTCAAAGTCTCCATGGAGCATTTGAAAAAAGCGACGGGAGTCAGTCAGACGGAGAAGATGGCAATAAGACCTACATAACCAAAGAGGGCACCTTACTGCCTTTCTCTACTTCGGAAGCTTCTCTGGGTCCAGTCCGTGGGCAGGGGAAAGAGGAGTCTGGGAAAGAAGCAGAAGGAAAGGGCAAGGAGGATTCCTACCTGATGGATAGTGACCTGGACTACAGTTCAGATGACAATATCTCCTGCCAAACTGCCCACAAAGAAGAAGACACCCCAGAAGAAAGCCCCCCAAACTCAAACCCTTCTAATAACAGCAACACCAGCTCCACGGGGAAGAACCGGCGGAGGAGAACTGCCTTCACCAGTGAACAACTGCTGGAACTAGAGAAAGAGTTCCACTGCAAGAAGTACCTGTCCCTGACAGAGAGATCCCAGATCGCACATGCGCTCAAACTTAGCGAAGTCCAGGTCAAAATATGGTTCCAGAACCGCAGAGCCAAGTGGAAGAGGGTCAAGGCTGGCAATGCGAACTCCAAAACTGGGGAGCCCTCTAGAAACCCTAAAATTGTTGTTCCCATCCCAGTCCATGTCAGTAGGTTTGCCATACGGAGCCAACACCAGCAGCTGGAGCAGACAAGACCTTGAAATGGTCAAAGGACAACAGCAAAGAAATCCATTTTGTGGCCCTCCAGTTGTTAATCTACATCTACCATGTAATTAGACAGTGGTGGAAGTTGTAGTTTTACGACAGTAATAGGGCCATAATATGGTCATCCCTGGACAATGAACAAATTAGCCACGGGGTCAGACAATGCAGGTTGTTGGTTGCCAATAACCAATTCCCTCCTAGACTTTCCAGAAAGACCCCAGTACTGATTATGTTAAGAAGGGGTGATTTTTGCACTTGAGGAGGCTAAAAGGTTAATTCTTCAGGAACTTAATTTTATGTATAGATAGATGGAAGCTGGCCACATTTAAGGGATGGCAGGTAAAACCTCTTAATTCTAATATTATGGACTTGATATGGACAGAGGTTTAGTGAGAACCGGAAACGGCCACAGGGTTGTGTTACCTGCAATGGAAAGTGCTGTGGGAGCATGTTGGTGATGGTGAAAAGAATATAACATCACCCCTTGGTACAATATCCTTTAACAAACTGAACTTGTTTTTCTAAACTCTCCCAGAGCCTCAAATTATGTTGTGGTTAATTTATTCTGTGTTGCTTATTTCTTATAAGTTATAAAACTTGAAAAAAAAAAAATGAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002932046|PREDICTED: homeobox protein GBX-2-like isoform 1 [Xenopus (Silurana) tropicalis] MSAAFQPPLMMMQRPLGSSTAFSIDSLIGSPPQPSPGHFVYTGYPMFMPYRPVVLPPPPPPPPSLSQATLQPTLPSAHPHHQIPSLPSGFCSSLAQGMALTSTLMATLPGGFSASAQHQEAARKFGAQSLQGAFEKSDGGQSDGEDGNKTYITKEGTLLPFSASEVSLGPVRGQGKEESGKEAEGKGKEDSYLMDSDLDYSSDDNISCQTAHKEDDTPEESPPNSNPSNNSNTSSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGNANSKTGEPSRNPKIVVPIPVHVSRFAIRSQHQQLEQARP	Refseq >NP_001083900|gastrulation brain homeobox 2, gene 1 [Xenopus laevis] MSAAFQPPLMMMQRPLGSSTAFSIDSLIGSPPQPSPGHFVYTGYPMFMPYRPVVLPPPPPPPPSLSQATLPSAHPHHQIPSLPSGFCSSLAQGMALTSTLMATLPGGFSASTQHQEAARKFGAQSLHGAFEKSDGSQSDGEDGNKTYITKEGTLLPFSTSEASLGPVRGQGKEESGKEAEGKGKEDSYLMDSDLDYSSDDNISCQTAHKEEDTPEESPPNSNPSNNSNTSSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGNANSKTGEPSRNPKIVVPIPVHVSRFAIRSQHQQLEQTRP

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.77345
Unigene EST Profile			EST Profile
GEO data			GEO
Images		12 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	GBX2
mouse		MGI	Gbx2	All(9) Targeted, knock Out(1) Targeted, other(8)
zebrafish		ZFIN	gbx2	4 Lines(s)

Publications
First:		The Xenopus laevis homeobox gene Xgbx-2 is an early marker of anteroposterior patterning in the ectoderm. [Mech Dev 1996]
Most recent:		Induction of the neural crest state: control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions. [Dev Biol 2012]
		View All Papers 3 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[R] Transcription factor zerknullt and related HOX domain proteins

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0			Xl.12088.1.S1_at
Affymetrix 2.0			Xl2.12088.1.S1_at

Symbol legend[+]

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