Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (46) GO Terms (25) Nucleotides (331) Proteins (32) Interactants (433) Wiki
XB-GENEPAGE-478821
Gene Symbol:
map2k1

Gene Name:
mitogen-activated protein kinase kinase 1

Synonyms:
mek1 ( Add synonyms , Nomenclature history )

Gene Function:
serine/threonine kinase

Protein Function :
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to th...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
cardiofaciocutaneous syndrome [+]

OMIM:
NOONAN SYNDROME 1; NS1 [+]

External Links:
 
Xenbase Gene ID XB-GENE-478822 XB-GENE-865216 XB-GENE-17341792
Gene Symbol map2k1 map2k1.L map2k1.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 493420
379991
108712802
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq RefSeq Swiss-Prot Swiss-Prot NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine map2k1 map2k1.L map2k1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards MAP2K1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Map2k1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Map2k1 Ensembl
zebrafish
ZFIN, AGR map2k1 ZFIN Ensembl
chicken
GEISHA MAP2K1 Ensembl
fruit fly
worm
Publications
First Molecular cloning and sequencing of a carp cDNA encoding mitogen-activated protein kinase kinase., Biochim Biophys Acta 1994  
Most Recent Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning., Development 2020  
All View All Papers 3 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 22 terms 6 terms 2 terms
PANTHER map2k1
KEGG Pathways K04368 K04368 K04368
KOG [T] Mitogen-activated protein kinase kinase (MAP2K)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks map2k1
Antibodies map2k1 Ab1 map2k1 Ab1 map2k1 Ab1
Morpholinos map2k1 AGT MO1 , map2k1 MO2 map2k1 AGT MO1 , map2k1 MO2 map2k1 AGT MO1 , map2k1 MO2
ORFs map2k1 ORF1 map2k1.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556