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Summary Expression Gene Literature (45) GO Terms (14) Nucleotides (317) Proteins (23) Interactants (429) Wiki
XB-GENEPAGE-478821
Gene Symbol: map2k1

Gene Name: mitogen-activated protein kinase kinase 1

Synonyms: mek1 ( Add synonyms , Nomenclature history )

Gene Function: serine/threonine kinase

Protein Function :
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to th...[+]

Interactants: Loading ...
Disease Ontology: cardiofaciocutaneous syndrome [+]

OMIM Diseases: NOONAN SYNDROME 1; NS1 [+]

 
Xenbase Gene ID XB-GENE-478822 XB-GENE-865216 XB-GENE-17341792
Gene Symbol map2k1 map2k1.L map2k1.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq TrEMBL RefSeq TrEMBL Swiss-Prot NCBI Protein TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine map2k1 map2k1.L map2k1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards MAP2K1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Map2k1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR map2k1 ZFIN Ensembl
chicken
GEISHA MAP2K1 Ensembl
fruit fly
worm
WORMBASE
Publications
First Molecular cloning and sequencing of a carp cDNA encoding mitogen-activated protein kinase kinase., Biochim Biophys Acta 1994  
Most Recent A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway., Front Physiol 2019                    
All View All Papers 3 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 11 terms 6 terms 2 terms
PANTHER map2k1
KEGG Pathways K04368 K04368 K04368
KOG [T] Mitogen-activated protein kinase kinase (MAP2K)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Antibody map2k1 Ab1 map2k1 Ab1 map2k1 Ab1
Morpholino map2k1 AGT MO1 , map2k1 MO2 map2k1 AGT MO1 , map2k1 MO2 map2k1 AGT MO1 , map2k1 MO2
ORF map2k1 ORF1 map2k1.L ORF1
Affymetrix 1.0 Str.10686.1.S1_a_at [+] Xl.5877.1.S1_at
Affymetrix 2.0 Xl2.5877.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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