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Summary Expression Gene Literature (23) GO Terms (20) Nucleotides (83) Proteins (24) Interactants (272) Wiki
XB-GENEPAGE- 481046

Gene Symbol: stat3.1

Gene Name: signal transducer and activator of transcription 3, gene 1

Synonyms: Xstat3 , aprf , hies , Stat3
Add Xenopus synonyms , Nomenclature history


Gene Function: intracellular signaling

Protein Function :
Transcription factor that binds to target promoter sequences and activates transcription upon il6st/gp130 stimulation. Mediates ventralization of embryos, at least in part via inhibition of smad2 signa...[+]


Interactants: Loading ...

Disease Ontology:
   JOB'S SYNDROME

OMIM Diseases:
   HYPER-IgE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT [+]
1/2
 

Xenbase Gene ID XB-GENE-481047 XB-GENE-865436 XB-GENE-17332303
Gene Symbol stat3.1 stat3.1.L stat3.1.S
Chromosome scaffold_113 Scaffold75417
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus PANTHER
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Xl.57141 [+]
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 10 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine stat3.1 stat3.1.L stat3.1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards STAT3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Stat3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR stat3 ZFIN Ensembl
chicken
GEISHA STAT3 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4. [Dev Biol 1999]
Most recent: JAK-STAT pathway activation in response to spinal cord injury in regenerative and non-regenerative stages of Xenopus laevis. [Regeneration (Oxf) 2017]
View All Papers 3 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 6 terms 20 terms 0 term
PANTHER stat3.1
KEGG Pathways K04692
KOG [KT] STAprotein
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 3 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience
Antibody Phospho-Stat3 (Tyr705) Ab1 , phospho-Stat3 Ab2 Phospho-Stat3 (Tyr705) Ab1 , phospho-Stat3 Ab2 Phospho-Stat3 (Tyr705) Ab1 , phospho-Stat3 Ab2
Morpholino stat3.1 MO1 stat3.1 MO1 stat3.1 MO1
Affymetrix 1.0 Str.15060.1.S1_at [+] Xl.916.2.S1_a_at [+]
Affymetrix 2.0 Xl2.916.2.S1_a_at [+]

Symbol legend[+]
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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556