Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (24) GO Terms (20) Nucleotides (83) Proteins (24) Interactants (308) Wiki
XB-GENEPAGE-481046

Gene Symbol: stat3.1

Gene Name: signal transducer and activator of transcription 3, gene 1

Synonyms: Xstat3 , aprf , hies , Stat3 ( Add Xenopus synonyms , Nomenclature history )

Gene Function: intracellular signaling

Protein Function :
Transcription factor that binds to target promoter sequences and activates transcription upon il6st/gp130 stimulation. Mediates ventralization of embryos, at least in part via inhibition of smad2 signa...[+]

Interactants: Loading ...
Disease Ontology: JOB'S SYNDROME

OMIM Diseases: HYPER-IgE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT [+]

1/2
 
Xenbase Gene ID XB-GENE-481047 XB-GENE-865436 XB-GENE-17332303
Gene Symbol stat3.1 stat3.1.L stat3.1.S
Chromosome scaffold_113 Scaffold75417
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein TrEMBL Refseq Swiss-Prot TrEMBL Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine stat3.1 stat3.1.L stat3.1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards STAT3 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Stat3 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR stat3 ZFIN Ensembl
chicken
GEISHA STAT3 Ensembl
fruit fly
worm
WORMBASE
Publications
First Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4., Dev Biol 1999                
Most recent AKT signaling displays multifaceted functions in neural crest development., Dev Biol 2018  
All View All Papers 3 paper(s) referencing morpholinos 24 paper(s) referencing OMIMs 24 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 6 terms 20 terms 0 term
PANTHER stat3.1
KEGG Pathways K04692
KOG [KT] STAprotein
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 3 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
Antibody Phospho-Stat3 (Tyr705) Ab1 , phospho-Stat3 Ab2 Phospho-Stat3 (Tyr705) Ab1 , phospho-Stat3 Ab2 Phospho-Stat3 (Tyr705) Ab1 , phospho-Stat3 Ab2
Morpholino stat3.1 MO1 stat3.1 MO1 stat3.1 MO1
Affymetrix 1.0 Str.15060.1.S1_at [+] Xl.916.2.S1_a_at [+]
Affymetrix 2.0 Xl2.916.2.S1_a_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.10.2


Major funding for Xenbase is provided by grant P41 HD064556