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Summary Expression Gene Literature (121) GO Terms (22) Nucleotides (97) Proteins (28) Interactants (345) Wiki
XB-GENEPAGE- 491845

Gene Symbol: chek1

Gene Name: checkpoint kinase 1

Synonyms: Chk1 , XChk1
Add Xenopus synonyms , Nomenclature history


Gene Function: serine/threonine kinase

Protein Function:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negative...[+]


Interactants: Loading ...

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-491846 XB-GENE-17335159 XB-GENE-866102
Gene Symbol chek1 chek1.L chek1.S
Chromosome scaffold_7 chr7L chr7S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide NCBI Nucleotide Refseq
Protein NCBI Protein NCBI Protein TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.52945 [+] Xl.406
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 15 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine chek1 chek1.L chek1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards CHEK1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Chek1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN chek1 ZFIN Ensembl
chicken
GEISHA CHEK1 Ensembl
fruit fly
worm
WORMBASE
Publications
First: The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. [J Cell Biol 1998]
Most recent: Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition. [Dev Cell 2017]
View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 3 terms 22 terms
EC now divided into EC:2.7.11.1, EC:2.7.11.8, EC:2.7.11.9, EC:2.7.11.10, EC:2.7.11.11, EC:2.7.11.12, EC:2.7.11.13, EC:2.7.11.21, EC:2.7.11.22, EC:2.7.11.24, EC:2.7.11.25, EC:2.7.11.30 and EC:2.7.12.1
PANTHER chek1
KEGG Pathways K02216 K02216
KOG [D] Checkpoint kinase and related serine/threonine protein kinases
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Chek1 Ab1 Chek1 Ab1
Morpholino chek1 MO1 chek1 MO1 chek1 MO1
ORF chek1 ORF1
Affymetrix 1.0 Str.40349.1.S1_at [+] Xl.406.2.S1_a_at [+]
Affymetrix 2.0 Xl2.406.1.S1_a_at [+]

Symbol legend[+]

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