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Summary Expression Gene Literature (587) GO Terms (26) Nucleotides (82) Proteins (37) Interactants (229) Wiki
XB-GENEPAGE-876601
Gene Symbol:
gja1

Gene Name:
gap junction protein alpha 1

Synonyms:
connexin 43 , connexin43 , cx43 , alpha 1 gap junction protein ( Add synonyms , Nomenclature history )

Gene Function:
connexon channel component

Protein Function :
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
erythrokeratodermia variabilis [+]

OMIM:
ERYTHROKERATODERMIA VARIABILIS ET PROGRESSIVA 1; EKVP1 [+]

External Links:
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Xenbase Gene ID XB-GENE-876602 XB-GENE-876609 XB-GENE-17334782
Gene Symbol gja1 gja1.L gja1.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 394450
373664
108717910
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine gja1 gja1.L gja1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards GJA1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Gja1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Gja1 Ensembl
zebrafish
ZFIN, AGR gja1b ZFIN Ensembl
chicken
GEISHA GJA1 Ensembl
fruit fly
worm
Publications
First Cloning and expression of a Xenopus embryonic gap junction protein., Science 1989  
Most Recent S-nitrosylation of connexin43 hemichannels elicits cardiac stress-induced arrhythmias in Duchenne muscular dystrophy mice., JCI Insight 2019  
All View All Papers 2 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 17 terms 15 terms 5 terms
PANTHER gja1
KEGG Pathways K07372 K07372 K07372
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks gja1
Morpholinos gja1 MO1 , gja1 MO2 gja1 MO1 , gja1 MO2 gja1 MO1 , gja1 MO2
ORFs gja1.L ORF1
Clones Horizon Source BioScience EXRC Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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