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Summary Expression Gene Literature (47) GO Terms (29) Nucleotides (82) Proteins (38) Interactants (365) Wiki
XB-GENEPAGE-920732
Gene Symbol:
insr

Gene Name:
insulin receptor

Synonyms:
Xe-InsR , insulin receptor , hhf5 , cd220 , XTK1 , XTK1a , XTK1b ( Add synonyms , Nomenclature history )

Gene Function:
growth factor receptor, contains protein kinase domain

Protein Function :
Receptor tyrosine kinase which mediates actions of insulin. May be required for forelimb regeneration.


InterPro :
Furin repeat , Rcpt L-dom sf , Kinase-like dom sf , Tyr kinase rcpt 2 CS [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Donohue syndrome [+]

OMIM:
DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS [+]

External Links:
1/2
 
Xenbase Gene ID XB-GENE-920733 XB-GENE-920741 XB-GENE-17333862
Gene Symbol insr insr.L insr.S
Chromosome Chr1 chr1L Scaffold21
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100492718
398006
100158430
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine insr insr.L insr.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards INSR OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Insr MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Insr Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR insrb insra ZFIN Ensembl
chicken
GEISHA INSR Ensembl
fruit fly
worm
Publications
First Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells., Proc Natl Acad Sci U S A 1985  
Most Recent Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study., Peptides 2021  
All View All Papers 3 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 21 terms 16 terms 5 terms
PANTHER insr
KEGG Pathways K04527 K04527 K04527
KOG [T] Insulin/growth factor receptor (contains protein kinase domain)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks insr
Antibodies Insr Ab1 Insr Ab1
Morpholinos (on-target & off-target) insr MO1 insr MO1 insr MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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