Gene Symbol: uba3 Gene Name: ubiquitin-like modifier activating enzyme 3 Synonyms: ube1c Add Xenopus synonyms Gene Function: ubiquitin-protein ligase Interactants:

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001122726|Xenopus (Silurana) tropicalis ubiquitin-like modifier activating enzyme 3 (uba3), mRNA GGTGCATTGTGGGAGGAGAGAGGCTGGGACGAATATGGCGGATGCTGAAGAGCCAATGGCTGTGGATGGTGGGTGTGGGGACACTGGAGACTGGGAAGGTCGCTGGAACCATGTAAAGAAGTTCCTCGAGCGATCAGGACCATTTACACACCCCGAGTTCGAACCAAGCAACGAATCTCTGCAGTTTCTCCTAGAAACCTGTAAAATTCTGGTTGTTGGAGCAGGAGGTTTAGGGTGCGAACTTCTCAAAAATCTGGCACTCTCTGGCTTTCGGCAGATCCATGTTATAGATATGGATACCATAGATGTTTCTAATTTAAACAGACAATTTCTGTTCCGGCCTAAAGATGTTGGAAGGCCTAAAGCAGAGGTTGCAGCAGAATTTATCAACACAAGGATCCCTGATTGCTGTGTCACACCGCACTTTACAAAAATACAAGATTTCGATGAAACGTTCTACCGAGAGTTTCATATCATTGTATGCGGGCTGGATTCAATTATTGCAAGGCGATGGCTGAACGGAATGCTGATGTCTCTTCTAAACTATGAAGACGGCGTGTTGCAGCAAAGTACGGTCATTCCCTTAATTGATGGAGGGACAGAGGGCTTTAAAGGAAATTCCAGAGTTATCCTACCAGGAATGACAGCCTGTGTAGAATGTACCCTTGAATTATACCCACCACAGATCAACTTCCCCATGTGTACAATAGCATCTATGCCCAGATTACCAGAGCACTGCATTGAGTACGTTCGGATACTTCAGTGGCCAAAGGAACAGCCATTTGGAGAGGGCGTGCAATTAGATGGGGACGACCCTGAACACATCCAGTGGATATTTATGAATTCGTTGGAGAGGGCGAAACAGTTCAACATTCGAGGTGTCACGTACAGACTTACTCAAGGTGTTGTAAAGAGAATTATTCCTGCTGTAGCCTCTACAAATGCTGTAATTGCAGCTGCCTGTGCCACTGAAGTTTTTAAAATAGCAACAAGCGCCTACATCCCACTGAACAATTACTTGGTGTTTAATGATGTTGATGGATTATACACTTACACCTTTGAAGCAGAAAAAAAGGAAAATTGTCCCGCTTGCAGCCAACTCCCACAGAACATCCAGTTTCCTTCTTCAGCCAAATTGCAGGAGGTGCTGGATTATTTGACAAATGACACATCACTACAGATGAAATCTCCTGCTATTACTGCAACACTGGATGGGAAAAATAAAACCCTTTATTTACAGACTGTAGCATCTATAGAAGAACGGACAAGGCCTAATCTTTGCAAGACATTGAAAGAGCTTGGTCTGGTCGACGGTCAGGAACTTGCGGTAGCCGACGTCACGACGCCGCAGACCGTGCTGTTCAAACTCCATTTTACAACCTAGTTTCACCGGCCGCGAGACTCTCGCTTGGTCCTTTTTAGCACTAGTTCATTTGGGAGCCTGATCCTAGCGCAAATGTACAGAAGTACGAAGGGGAGATGTGGAACATTAACCCTTGGCTGTACTGCTGGGAAGAAAGGGGCTCCACTTTCCTTACTGCAACCCCCCCAAGAAGGCGGAGTCTGAAAAAATGCTCGCGTAGTACAATTAAGCACCTATTTATAAAACAATATCGGTATCTTTTTAGAAGGCGGCAGGAGCATTTTAAAATTACACTTTTAGAATTGCCCAAGATGTACAGTGTTCTGTTTGAATAAATGAACCATGTAATGACTGTATCATGTACAAAGCCATGTATGTCTTTTATGTAATTTTTCTTATGACAAAACCTTAGGGGGAAAAATTAATTAGTGTAATTAGGCAAAATAAACCCTCTGTACATTGAAAAATAAAGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001096250|Xenopus laevis ubiquitin-like modifier activating enzyme 3 (uba3), mRNA GGTGCATCGTGGGAGGAGAGAGGCTGGGAGGAATATGGCGGATGCTGAAGAGCCGGAGAAGAAAAGAAGGCGGATAGAAGAGCTCCCTGACGAAATGGCTGTGAATGGTGGGTGTGGGGAGACTGGAGACTGGGAAGGTCGCTGGAACCATGTAAAGAAGTTCCTCGAGCGATCAGGACCATTTACACACCCTGAGTTCGAACCAAGCAACGAATCTCTGCAGTTTCTCCTCGAAACCTGTAAACTTCTGGTTGTTGGAGCAGGAGGTCTAGGGTGCGAACTTCTCAAAAACCTGGCACTCTCTGGCTTTCGGCAGATCCATGTTATAGATATGGACACCATAGATGTTTCTAATTTAAACAGACAGTTTCTGTTCCGGCCTAAGGATGTTGGAAGGCCTAAAGCAGAGGTTGCAGCAGATTTTATAAACGCAAGGATCCCTGATTGCTGTGTCACTCCGCATTTTAAGAAAATACAAGACTTTGATGAAACATTCTACCGAGAGTTTCATATCATTGTATGCGGACTGGATTCAATTATTGCAAGGCGATGGCTAAATGGAATGCTGATGTCTCTTCTAAATTATGAAGACAGCGTGTTGCAGCAAAGTACAGTCATCCCCTTAATTGATGGAGGGACAGAGGGCTTTAAAGGAAACTCCAGAGTTATCCTACCAGGAATGACAGCCTGTGTAGAATGTACCCTTGAATTATACCCACCACAGATCAACTTTCCCATGTGTACAATAGCATCCATGCCCAGATTACCAGAGCACTGCATTGAGTATGTTCGGATACTTCAGTGGCCAAAGGAACAGCCATTTGGAGAGGGTGTGCAGTTAGATGGAGATGACCCTGAACACATAGAGTGGATATTTACAAATTCATTGGAAAGGGCAAACCAGTTCAACATTCGAGGCGTCACTTACAGACTTACTCAAGGTGTTGTCAAGCGAATTATTCCTGCTGTAGCCTCAACGAATGCTGTAATTGCAGCTGCCTGTGCCACTGAAGTTTTTAAAATAGCAACAAGCGCCTACATCCCGCTTAACAATTACCTGGTGTTTAATGATGTTGATGGATTATACTCTTACACCTTTGAAGCAGAAAAAAAGGAAAATTGTCCTGCCTGCAGCCAGCTCCCACAGAACATCCAGTTTCCTTCTTCAGCCAAATTGCAGGAGGTGCTGGATTATTTGACAAATGACACATTACAAATGAAAGCTCCTGCTATTACTGCAACACTGGAGGGGAAAAATAAAACCCTCTATTTACAGACTGTAACATCTATAGAAGAACGGACAAGGCCCAATCTTTGCAGGACATTGAAAGAGCTCGGCCTCGTCGATGGTCAGGAACTTGCAGTGGCCGACGTCACAACGCCGCAAACTGTGCTGTTCAAACTGCATTTTACAGCCTAGTGTCACTATCACATGGTCCTTTTTAGCACTAGTTCATTTGGAAGCCTGATCCTAGCGTAAATGTACAGAAGTATGAAGGAGAGATGTGAAACATTAACCCTTGGCTGTACTGTTGGGAAGAAAGGGGCTCCGCTTTCCTTACTGCAACCCTCAAGAAGGTGGAGCCTGAAAATGCTCTCGTTCTAGTCCAATGAAGCACCTATTTATAAAAGTGAGACAAAAATATCAGTATCTTTTTTTTTTAGAAGGCAGCAGGAGCATTTTAAAATGACACTTTTAGAATTGCCCAAAATGTACAGTGTTCTATTTGAATATATGAACCATGTTATGAGTGTATCATGTACAAAGCAATGTATGTCTTTTATGTATTGGGCGGGGGAGGGAATTAGAATTGTAAACAGTGTAATTAGGAAAAATAAACCATCTGTACATTGAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001116198|ubiquitin-like modifier activating enzyme 3 [Xenopus (Silurana) tropicalis] MADAEEPMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPEFEPSNESLQFLLETCKILVVGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDVGRPKAEVAAEFINTRIPDCCVTPHFTKIQDFDETFYREFHIIVCGLDSIIARRWLNGMLMSLLNYEDGVLQQSTVIPLIDGGTEGFKGNSRVILPGMTACVECTLELYPPQINFPMCTIASMPRLPEHCIEYVRILQWPKEQPFGEGVQLDGDDPEHIQWIFMNSLERAKQFNIRGVTYRLTQGVVKRIIPAVASTNAVIAAACATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAEKKENCPACSQLPQNIQFPSSAKLQEVLDYLTNDTSLQMKSPAITATLDGKNKTLYLQTVASIEERTRPNLCKTLKELGLVDGQELAVADVTTPQTVLFKLHFTT	Refseq >NP_001089719|ubiquitin-like modifier activating enzyme 3 [Xenopus laevis] MADAEEPEKKRRRIEELPDEMAVNGGCGETGDWEGRWNHVKKFLERSGPFTHPEFEPSNESLQFLLETCKLLVVGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDVGRPKAEVAADFINARIPDCCVTPHFKKIQDFDETFYREFHIIVCGLDSIIARRWLNGMLMSLLNYEDSVLQQSTVIPLIDGGTEGFKGNSRVILPGMTACVECTLELYPPQINFPMCTIASMPRLPEHCIEYVRILQWPKEQPFGEGVQLDGDDPEHIEWIFTNSLERANQFNIRGVTYRLTQGVVKRIIPAVASTNAVIAAACATEVFKIATSAYIPLNNYLVFNDVDGLYSYTFEAEKKENCPACSQLPQNIQFPSSAKLQEVLDYLTNDTLQMKAPAITATLEGKNKTLYLQTVTSIEERTRPNLCRTLKELGLVDGQELAVADVTTPQTVLFKLHFTA

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.4967 [+] Str.39305	Xl.13960 [+] Xl.58559
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	UBA3
mouse		MGI	Uba3	All(5) Targeted, knock Out(1) Gene Trapped(1) Targeted, other(2)
zebrafish		ZFIN	uba3

Publications
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Most recent:
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Functional Ontologies
GO: Molecular:		catalytic activity ubiquitin activating enzyme activity ubiquitin-protein ligase activity
Biological:		protein modification process ubiquitin cycle
Cellular Component:
EC:		ubiquitinprotein ligase
KOG:		[O] NEDD8-activating complex, catalytic component UBA3

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.39305.1.S1_at [+] Str.4967.1.S1_at	Xl.15474.1.A1_at [+] Xl.13960.1.A1_at
Affymetrix 2.0			Xl2.13960.1.S1_at

Symbol legend[+]

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