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Summary Expression Gene Literature (11) GO Terms (9) Nucleotides (175) Proteins (47) Interactants (41) Wiki
Gene Symbol:

Gene Name:
SPC25, NDC80 kinetochore complex component

( Add synonyms , Nomenclature history )

Gene Function:
Uncharacterized conserved protein

Protein Function :
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integ...[+]

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External Links:
Xenbase Gene ID XB-GENE-950628 XB-GENE-950634 XB-GENE-17334828
Gene Symbol spc25 spc25.L spc25.S
Chromosome Chr8 chr8L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 448571
mRNA RefSeq NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine spc25 spc25.L spc25.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC AGR, OMIM:Gene, GeneCards SPC25 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Spc25 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Spc25 Ensembl
ZFIN, AGR spc25 ZFIN Ensembl
GEISHA SPC25 Ensembl
fruit fly
FLYBASE Spc25 Ensembl
First The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment., Curr Biol 2004  
Most Recent Cenp-meta is required for sustained spindle checkpoint., Biol Open 2014          
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 8 terms 7 terms 0 term
KEGG Pathways K11550 K11550
KOG [S] Uncharacterized conserved protein (alt_id KOG:4657)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks spc25
ORFs spc25 ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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