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Summary Expression Gene Literature (107) GO Terms (32) Nucleotides (313) Proteins (58) Interactants (294) Wiki
XB-GENEPAGE-950934
Gene Symbol:
pam

Gene Name:
peptidylglycine alpha-amidating monooxygenase

Synonyms:
pal , phm , pam-a , pam-b , AE-I ( Add synonyms , Nomenclature history )

Gene Function:
Peptidylglycine alpha-amidating monooxygenase

Protein Function :
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated t...[+]


InterPro :
WD40 repeat CS , CORO7 , WD40 repeat dom sf , WD40 repeat [+]

Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-950935 XB-GENE-950939 XB-GENE-6252615
Gene Symbol pam pam.L pam.S
Chromosome Chr01 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100170159
379207
397736
mRNA RefSeq RefSeq RefSeq
Protein RefSeq RefSeq  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine pam pam.L pam.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PAM OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Pam MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Pam Ensembl
zebrafish
ZFIN, AGR pam ZFIN Ensembl
chicken
GEISHA PAM Ensembl
fruit fly
worm
Publications
First Peptide C-terminal alpha-amidating enzyme purified to homogeneity from Xenopus laevis skin., Biochem Biophys Res Commun 1986  
Most Recent CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis., Sci Rep 2020                                    
All View All Papers 2 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 31 terms 7 terms 7 terms
PANTHER pam
KEGG Pathways K24006 K24006 [+] K18200 [+]
KOG [O] Peptidylglycine alpha-amidating monooxygenase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks pam
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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