Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (48) GO Terms (9) Nucleotides (212) Proteins (34) Interactants (222) Wiki
XB-GENEPAGE- 952024

Gene Symbol: ptk2

Gene Name: protein tyrosine kinase 2

Synonyms: fak , pp125FAK , XPFAK
Add Xenopus synonyms , Nomenclature history


Gene Function: Focal adhesion tyrosine kinase FAK, contains FERM domain

Protein Function:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin cluste...[+]


Interactants: YYY

OMIM Disease Associations:
1/2
 
Xenbase Gene ID XB-GENE-952025 XB-GENE-952029 XB-GENE-17337918
Gene Symbol ptk2 ptk2.L ptk2.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq Refseq
Protein NCBI Protein Refseq Swiss-Prot Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.16767 Xl.6819
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 16 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine ptk2 ptk2.L ptk2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards PTK2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Ptk2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN ZFIN ptk2ab ptk2aa ZFIN Ensembl
chicken
GEISHA PTK2 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Fibrillarin: a new protein of the nucleolus identified by autoimmune sera. [Biol Cell 1985]
Most recent: Adhesive crosstalk in gastrulation. [Dev Cell 2017]
View All Papers 3 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 8 terms 6 terms
EC now EC:2.7.10.1 and EC:2.7.10.2
PANTHER ptk2
KEGG Pathways K05725 K05725
KOG [T] Focal adhesion tyrosine kinase FAK, contains FERM domain
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Ptk2 Ab1 , Ptk2 Ab2 Ptk2 Ab1 , Ptk2 Ab2
Morpholino ptk2 MO1 , ptk2 MO2 , ptk2 MO3 , ptk2 MO4 , ptk2 MO5 , ptk2 MO6 , ptk2 MO7 ptk2 MO1 , ptk2 MO2 , ptk2 MO3 , ptk2 MO4 , ptk2 MO5 , ptk2 MO6 , ptk2 MO7 ptk2 MO1 , ptk2 MO2 , ptk2 MO3 , ptk2 MO4 , ptk2 MO5 , ptk2 MO6 , ptk2 MO7
ORF MGC83487 ORF1
Affymetrix 1.0 Str.39333.2.A1_at [+] Xl.6819.1.S2_at [+]
Affymetrix 2.0 Xl2.6819.1.S1_at Xl2.47058.1.S1_at

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.5.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556