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Summary Expression Gene Literature (12) GO Terms (6) Nucleotides (218) Proteins (39) Interactants (236) Wiki
XB-GENEPAGE-954260
Gene Symbol:
ldlrap1

Gene Name:
low density lipoprotein receptor adaptor protein 1

Synonyms:
arh , arh1 , arh2 , fhcb1 , fhcb2 , xptb , ldlrap1-a , ldlrap1-b ( Add synonyms , Nomenclature history )

Gene Function:
Adaptor protein CED-6, contains PTB domain

Protein Function :
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR). Also involved in the vitellogenin receptor mediated endocytosis of nutrients...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
autosomal recessive hypercholesterolemia

OMIM:
HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE; ARH

External Links:
 
Xenbase Gene ID XB-GENE-954261 XB-GENE-954266 XB-GENE-6256035
Gene Symbol ldlrap1 ldlrap1.L ldlrap1.S
Chromosome Chr02 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 549868
414519
398568
mRNA RefSeq RefSeq RefSeq
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine ldlrap1 ldlrap1.L ldlrap1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards LDLRAP1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Ldlrap1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Ldlrap1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR ldlrap1b ldlrap1a ZFIN Ensembl
chicken
GEISHA LDLRAP1 Ensembl
fruit fly
worm
Publications
First ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2., J Biol Chem 2002  
Most Recent High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration., Development 2017                                                                                          
All View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 3 terms 3 terms 3 terms
PANTHER ldlrap1
KEGG Pathways K12474 K12474 K12474
KOG [R] Adaptor protein CED-6, contains PTB domain
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks ldlrap1
Antibodies Ldlrap1 Ab1 Ldlrap1 Ab1 Ldlrap1 Ab1
ORFs ldlrap1.S ORF1
Clones Horizon Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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