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Summary Expression Gene Literature (2) GO Terms (12) Nucleotides (123) Proteins (39) Interactants (15) Wiki
XB-GENEPAGE-971728
Gene Symbol:
unc45b

Gene Name:
unc-45 myosin chaperone B

Synonyms:
cmya4 , unc45 , smunc45 , dicky ticker ( Add synonyms , Nomenclature history )

Gene Function:
Myosin assembly protein/sexual cycle protein and related proteins

Protein Function :
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell assembly. Is necessary for normal early lens devel...[+]


InterPro :
Armadillo , UCS central dom , TPR-contain dom , TPR repeat [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
cataract 43

OMIM:
CATARACT 43; CTRCT43

External Links:
1/2
 
Xenbase Gene ID XB-GENE-971729 XB-GENE-17343539 XB-GENE-971733
Gene Symbol unc45b unc45b.L unc45b.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 493194
108708296
447296
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein TrEMBL RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine unc45b unc45b.L unc45b.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards UNC45B OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Unc45b MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Unc45b Ensembl
zebrafish
ZFIN, AGR unc45b ZFIN Ensembl
chicken
GEISHA UNC45B Ensembl
fruit fly
worm
Publications
First Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky ticker., BMC Dev Biol 2010                      
Most Recent Contractile activity is required for Z-disc sarcomere maturation in vivo., Genesis 2015                  
All View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 3 terms 5 terms
PANTHER unc45b
KEGG Pathways K21991 K21991 K21991
KOG [ODR] Myosin assembly protein/sexual cycle protein and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks unc45b
Morpholinos (on-target & off-target) unc45b MO1 , unc45b MO2 unc45b MO2 unc45b MO2
ORFs unc45b.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info