pcna Summary [species: Xenopus laevis and Xenopus tropicalis]

Summary

Expression

XB-GENEPAGE-972521

[provisional- machine annotated only]

Gene Symbol: pcna [Predicted: Source is Human Entrez Gene]

Gene Name: proliferating cell nuclear antigen [Predicted: Source is Human Entrez Gene]

Add Xenopus synonyms

Gene Function: DNA polymerase delta processivity factor (proliferating cell nuclear antigen)

Interactants: cdkn1a(14) , cdt1(9) , dtl(9) , pola1(9) , cdk2(7) , mcm2(6) , rpa1(6) View All

XB-GENE-972522

XB-GENE-972527

Molecules	tropicalis	laevis
Gene	JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
	Entrez Gene	Entrez Gene
mRNA	Refseq >NM_001007920\|Xenopus (Silurana) tropicalis proliferating cell nuclear antigen (pcna), mRNA CGGAGCTTCAGTTGGGAGGAGGTACCACAGAGGTACTAGGGAATTCAGCTACTGAGCTCCGCCATCTGCACCCCCCGGCACACTTCTCTCTTTCCCCAGCTCCGTACAGCCGTCACCATGTTTGAAGCTCGCTTGGTGCAGGGTTCCATCCTGAAGAAAGTGCTGGAGGCCCTGAAGGACCTGATCGATGAGGCGTGCTGGGACATCACATCGAGCGGCATCAGCTTGCAGAGCATGGACTCCTCGCACGTCTCGTTGGTGCAGCTCACTCTGCGATCGGACGGCTTTGACACCTACAGGTGCGATCGCAATCAATCCATCGGCGTCAAGATGAGCAGTATGTCTAAGATCTTGAAGTGTGCTGCAAGTGAAGATATCATTACTCTGAGGGCAGAAGACAATGCTGATACAGTTACAATGGTGTTTGAGTCGCCAAATCAAGAGAAAGTTTCTGACTATGAAATGAAGCTAATGGACCTTGATGTGGAGCAGCTGGGCATTCCTGAACAAGAGTACAGCTGTGTAATAAAGATGCCATCTGGTGAATTTGCACGCATCTGCAGAGATCTAAGCCAGATTGGTGACGCAGTTGTTATTTCTTGTGCAAAGGATGGGGTAAAGTTCTCTGCAAGTGGAGAGCTGGGCACTGGAAACGTAAAGCTGTCACAAACTTCAAATGTGGATAAAGAGGAGGAAGCTGTTACAATAGAAATGAATGAGCCAGTACAGCTTACATTTGCTTTGCGGTACCTGAACTTCTTTACCAAAGCTACACCCCTGTCCCCAACAGTTACACTCAGTATGTCTGCAGATATCCCACTTGTTGTGGAATACAAAATCGCAGATATGGGTCATGTGAAATATTACCTGGCTCCCAAGATTGAAGATGAAGAAGCTTCATAATATCTGAACTAGCTTATTTTATAAACCTTAACCGAACGTCAGATGGCGCTTTTTGACACCTGCCTTGTGTTAACAGCTTTGGCTGAACATACCCAACCTGTAACAACTGGCTGTACTTCTAGGCATGTCTGTAGATATTCTTGTAAATATGTCACAATTTTTGTAAAATCTCTGCCCTATGAAGTCAATAAATCTTTGTAATAACAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001087542\|Xenopus laevis proliferating cell nuclear antigen (pcna), mRNA TTGAAGTACCGTCGCGGTAATCCCTTACAGCCGCCGCCATGTTTGAGGCTCGCTTGGTGCAGGGTTCCATCCTGAAGAAGGTGTTGGAGGCCCTGAAGGACCTAATCGATGAGGCGTGCTGGGACATTACATCCAGCGGCATCAGCTTGCAGAGCATGGATTCCTCGCACGTCTCGCTGGTTCAGCTCACTCTGCGATCAGACGGCTTTGACACCTACCGGTGTGATCGCAATCAATCTATCGGCGTCAAGATGAGCAGTATGTCCAAAATCTTGAAGTGTGCCGCAAGTGACGATATCATTACTCTGAGGGCAGAAGACAATGCTGATACAGTCACAATGGTGTTTGAGTCGCCAAATCAAGAGAAAGTTTCAGACTATGAAATGAAGTTAATGGACCTTGATGTGGAGCAGCTGGGCATTCCTGAACAAGAGTACAGCTGTGTAATAAAGATGCCATCTGGTGAATTTGCACGTATCTGCCGAGATCTCAGCCAGATTGGTGACGCAGTAGTAATTTCTTGTGCTAAGGATGGGGTAAAGTTCTCTGCAAGCGGAGAGCTGGGAACTGGAAATGTAAAGCTGTCACAGACTTCAAATGTGGATAAAGAAGAGGAAGCTGTTACAATAGAAATGAATGAGCCAGTACAGCTTACATTTGCTTTGCGGTATCTGAACTTCTTCACCAAAGCTACACCCCTGTCCCCAACAGTTATTCTCAGTATGTCTGCAGATATCCCACTTGTTGTGGAATACAAAATTGCAGATATGGGACATGTGAAATACTACCTGGCTCCCAAGATTGAAGATGAAGAAGCTTCTTAATGTCTGAACTAGCTTATTTTATAAACCTCAACTGAACGTCCAATGGCGCTTTCACACACCTGCCTTGTTTTAACAGCTTTGGCTGAACCTACCCAACTTGTACCAACTGGCTGTACTTCTAGGCATGTCTGTAGATATTTTTGTAAATACGTCACGATTTTTGTAAAATCTCTGCCCTAGGAGGTCAATAAATCTTTGTAATAACAAACACGAAAAAAAAAAAAAAA
Protein	Refseq >NP_001007921\|proliferating cell nuclear antigen [Xenopus (Silurana) tropicalis] MFEARLVQGSILKKVLEALKDLIDEACWDITSSGISLQSMDSSHVSLVQLTLRSDGFDTYRCDRNQSIGVKMSSMSKILKCAASEDIITLRAEDNADTVTMVFESPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVIKMPSGEFARICRDLSQIGDAVVISCAKDGVKFSASGELGTGNVKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVTLSMSADIPLVVEYKIADMGHVKYYLAPKIEDEEAS	Refseq >NP_001081011\|proliferating cell nuclear antigen [Xenopus laevis] MFEARLVQGSILKKVLEALKDLIDEACWDITSSGISLQSMDSSHVSLVQLTLRSDGFDTYRCDRNQSIGVKMSSMSKILKCAASDDIITLRAEDNADTVTMVFESPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVIKMPSGEFARICRDLSQIGDAVVISCAKDGVKFSASGELGTGNVKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSPTVILSMSADIPLVVEYKIADMGHVKYYLAPKIEDEEAS UniProtKB

Genomic	tropicalis
Genome Browser	Xenbase	Xenbase JGI Ensembl UCSC	Xenbase

Synteny	Metazome

Expression	tropicalis	laevis
UniGene	Str.6228 [+] Str.41693 Str.47241	Xl.34965
Unigene EST Profile	EST Profile	EST Profile
GEO data		GEO
Images	8 expression image(s) for tropicalis and laevis

Orthology	MOD	Entrez Gene	Genetic Phenotypes	Morphants
human	OMIM:Gene, HGNC	PCNA
mouse	MGI	Pcna	All(5) Targeted, knock Out(1) Targeted, other(4)
zebrafish	ZFIN	pcna

Publications
First:		DNA replication and cell cycle control in Xenopus egg extracts. [J Cell Sci Suppl 1989]
Most recent:		Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation. [Cell Div 2013]
		View All Papers 5 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding DNA polymerase processivity factor activity DNA-directed DNA polymerase activity More[+] alpha DNA polymerase activity beta DNA polymerase activity delta DNA polymerase activity epsilon DNA polymerase activity eta DNA polymerase activity gamma DNA-directed DNA polymerase activity iota DNA polymerase activity kappa DNA polymerase activity lambda DNA polymerase activity mu DNA polymerase activity nu DNA polymerase activity sigma DNA polymerase activity theta DNA polymerase activity zeta DNA polymerase activity
Biological:		regulation of DNA replication
Cellular Component:		delta-DNA polymerase cofactor complex nucleus
EC:		DNA-directed DNA polymerase
KOG:		[L] DNA polymerase delta processivity factor (proliferating cell nuclear antigen)

Reagents	tropicalis	laevis
Clones		EXRC - 1 clone(s)
	open biosystems	open biosystems
	geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0	Str.6228.1.S1_at [+] Str.47241.1.A1_at	Xl.840.1.S1_at [+] Xl.840.1.S1_s_at
Affymetrix 2.0		Xl2.34965.1.S1_at

Symbol legend[+]