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Summary Expression Gene Literature (24) GO Terms (106) Nucleotides (177) Proteins (48) Interactants (487) Wiki
XB-GENEPAGE-977112
Gene Symbol:
fmr1

Gene Name:
fragile X mental retardation 1

Synonyms:
fmr-1 , fmrp , fmr1-a , fmr1-b ( Add synonyms , Nomenclature history )

Gene Function:
RNA binding, putative role in synaptic protein synthesis

Protein Function :
Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
fragile X-associated tremor/ataxia syndrome [+]

OMIM:
FRAGILE X SYNDROME; FXS [+]

External Links:
1/5
 
Xenbase Gene ID XB-GENE-977113 XB-GENE-6252724 XB-GENE-977118
Gene Symbol fmr1 fmr1.L fmr1.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 448049
373706
735034
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine fmr1 fmr1.L fmr1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards FMR1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Fmr1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Fmr1 Ensembl
zebrafish
ZFIN, AGR fmr1 ZFIN Ensembl
chicken
GEISHA FMR1 Ensembl
fruit fly
FLYBASE Fmr1 Ensembl
Publications
First FXR1, an autosomal homolog of the fragile X mental retardation gene., EMBO J 1995  
Most Recent FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells., J Cell Biol 2020                                                
All View All Papers 3 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 105 terms 84 terms 86 terms
PANTHER fmr1
KEGG Pathways K15516 K15516 K15516
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks fmr1
Morpholinos fmr1 MO2 , fmr1 MO1 fmr1 MO2 , fmr1 MO1 fmr1 MO2 , fmr1 MO1
ORFs fmr1 ORF1 fmr1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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