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Summary Expression Gene Literature (17) GO Terms (4) Nucleotides (60) Proteins (24) Interactants (64) Wiki
XB-GENEPAGE-979946
Gene Symbol:
dio1

Gene Name:
deiodinase, iodothyronine type 1

Synonyms:
type I iodothyronine deiodinase , type 1 deiodinase , deiodinase I ( Add synonyms , Nomenclature history )

Gene Function:
thyroxine 5'-deiodinase

Protein Function :
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).


Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-979947 XB-GENE-979948 XB-GENE-17345940
Gene Symbol dio1 dio1.L dio1.S
Chromosome Chr04 chr4L
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 100497874
733447
mRNA RefSeq RefSeq
Protein RefSeq RefSeq Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine dio1 dio1.L dio1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards DIO1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Dio1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Dio1 Ensembl
zebrafish
ZFIN, AGR dio1 ZFIN Ensembl
chicken
GEISHA DIO1 Ensembl
fruit fly
worm
Publications
First Type I iodothyronine deiodinase is a selenocysteine-containing enzyme., Nature 1991  
Most Recent Reference gene identification and validation for quantitative real-time PCR studies in developing Xenopus laevis., Sci Rep 2018              
All View All Papers 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 4 terms 0 term
PANTHER dio1
KEGG Pathways K01562
KOG
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks dio1
Clones Horizon Source BioScience Horizon Source BioScience

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