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Summary Expression Gene Literature (283) GO Terms (18) Nucleotides (70) Proteins (34) Interactants (105) Wiki
XB-GENEPAGE-982766
Gene Symbol:
scn4a

Gene Name:
sodium channel, voltage gated, type IV alpha subunit

Synonyms:
nav1.4 , na(v)1.4 ( Add synonyms , Nomenclature history )

Gene Function:
Voltage-gated Ca2+ channels, alpha1 subunits

Protein Function :
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sod...[+]


InterPro :
Volt channel dom sf , Na channel asu , Na trans assoc , IQ motif EF-hand-BS [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
congenital myasthenic syndrome 16 [+]

OMIM:
HYPOKALEMIC PERIODIC PARALYSIS, TYPE 1; HOKPP1 [+]

External Links:
 
Xenbase Gene ID XB-GENE-982767 XB-GENE-17336552 XB-GENE-17336553
Gene Symbol scn4a scn4a.L scn4a.S
Chromosome Chr10 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model
Entrez Gene 100492371
mRNA NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine scn4a scn4a.L scn4a.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SCN4A OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Scn4a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Scn4a Ensembl
zebrafish
chicken
GEISHA SCN4A Ensembl
fruit fly
worm
Publications
First Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis., Biophys J 2001  
Most Recent Myasthenic congenital myopathy from recessive mutations at a single residue in NaV1.4., Neurology 2019              
All View All Papers 2 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 18 terms 0 term 0 term
PANTHER scn4a
KEGG Pathways
KOG [PT] Voltage-gated Ca2+ channels, alpha1 subunits
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks scn4a
Clones Horizon
Plasmids Addgene Addgene

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