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Summary Expression Gene Literature (9) GO Terms (8) Nucleotides (64) Proteins (21) Interactants (64) Wiki
XB-GENEPAGE-988967

Gene Symbol: apaf1

Gene Name: apoptotic peptidase activating factor 1

Synonyms: apaf-1 ( Add synonyms , Nomenclature history )

Gene Function: apoptosis/apoptosome scaffold protein with WD-40 domains, caspase recruitment domain (CARD), and an ATPase domain

Protein Function :
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Interactants: Loading ...
Disease Ontology:

OMIM Diseases:

 
Xenbase Gene ID XB-GENE-988968 XB-GENE-988971 XB-GENE-17330402
Gene Symbol apaf1 apaf1.L apaf1.S
Chromosome Chr03 chr3L
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide RefSeq
Protein TrEMBL RefSeq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine apaf1 apaf1.L apaf1.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards APAF1 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Apaf1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR apaf1 ZFIN Ensembl
chicken
GEISHA APAF1 Ensembl
fruit fly
worm
WORMBASE
Publications
First Bcl-xL does not inhibit the function of Apaf-1., Cell Death Differ 2000  
Most Recent Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation., Genetics 2016  
All View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 7 terms 5 terms 0 term
PANTHER apaf1
KEGG Pathways K02084
KOG [T] Apoptotic ATPase
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
ORF apaf1 ORF1 apaf1.L ORF1
Affymetrix 1.0 Str.42521.1.S1_at [+]
Affymetrix 2.0 Xl2.47594.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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