clspn Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (31)

Nucleotides (130)

Interactants (36)

XB-GENEPAGE-992186

Gene Symbol: clspn Gene Name: claspin Synonyms: xClaspin, claspin Add Xenopus synonyms Gene Function: regulation of cell cycle checkpoints Interactants: atr(26) , chek1(26) , antxr1(22) , atm(5) , rad17(5) , cdc45(4) , plk1(4) View All	1/4

XB-GENE-992187

XB-GENE-6251915

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002938839\|PREDICTED: Xenopus (Silurana) tropicalis claspin (clspn), partial mRNA CGCGAATTCTGAGGCGGCAGCTGGGAAGATTGGCGGGAGCTGTCAGCAGATAGCACCATGGCCGCGCTTTGTGAAGAAGAGCAGTTAGTTTTGGAACCAGAAGACAGCATCAGTCTGAAGATCTTGGAGACAGATTCTGACAGTGGTCAGGGCAGCTGTGAAATGGCTTCTGCTGATGATCAGAACAAAATATTGGATTGTATAGAGGACAGAGATACAGATGAAGAAGAATTCTTGGTGTGTAAAAAATCTAAAAGCAAGAAAATATTGGTGGAAAGTGACAGTGATGAAGAAATGGAAACAAGTAAAATTGCAGATAATGTGAAGGGGAACTCTAAAAATGATGAGGAGAACAATATTTCTGCTCATAGAGAAAAGCCACGAAGAATCCAGTCAGCTCTATTTGATAGTGACAACAGTGATAACGAGGTTGATGTTCAAATGAGTACACGTCAAAATACTATTGAGAGACCTGAGTCAGACCACGGTAGCTTGGAGAAAGAATCCCCTACAGTCAAGCATAAAACAAGCAAGTCCTTGAAGAAACAAGGTGACACCAATAAAGAGAAAAGAGTGAAAAATAAATCGAAGCACAAAATACAGAAAGAGGAGAAGGTTAAAAGGAGGACACAGCAAAAGTCAAAAGCAGTGAAGGAGGATAGGCCAAATTTAAATGACAGTGGCTGCCTACTCAATGGAGATCTTTTTGAAAACGAAGTGGGAAGTGGGGTGGATTCTAATGAAGAAGAGGAATCTCTTGATGCTATCCGCACAAAAATAAAAGGAAAACTGAATAGTCATTCTACTGAAGATTATGAAGGCTTTGAACTTGAAACTGAAGGGATGCAAGAAACCCAAGAAAAACGAAAGGAACGAAAAGCTGCTAGACTTGGTAAAGAAGCCATGAAACAAATGCACAGTGAGACCCAAAGACTGATGCGAGAATCTTCCGTATCTTTACCATATCACTTACCTGAACCGAAAACAATCCATGATTTTTTCAGAAGGCGCCCAAGGCCTCTTTGTCAAGGAAATGCAATGCACCTTATAAAGTCAACAAAGTACCAACCCTGCACTGAAGAAAAAAAGAACACCAAAGAGGAAATTTGTGCTGAAGTTCAAAAGGGTGATTATGTTTCAAAGGAAGATTTAGAAATCAGTGAAGAAAATAATTTGTTAAATCCTCAGTGTTCACATGCTGCTGCACTATTAGATGTGCAAAAGGATGCTCATACCGAGGGGATAAGTAAATCCACAGAGACAGTTGTGAATGGTGAAATTAATGAAAACTTGATACAGTTGGACAAGGAGGACACTTTCAACCACAACAACAATGTTCACAAACAAGAAGCAGTTGGATTAATAGCTGTAAATGAAATATTTCAGTCACCTTCTATTCTCCAGCCAGAGAGTACAGTTTGTGAACAAATTCAGAATAATGTAGACAGCAACCTTATGCCTGAGCAACCCTTGCATAAACCCAAGCTATCCAAGCTTGAAAAGCTGCGGGCTCTTGGAGTGGACTTGTCTATAAAACCCCGCCTTTGCCCTAATGATGGTTCTTTTGTCAACTTAGATGAACCAAAGCCGAATAAAGAATTTGAAGCTTTGAAGGAGCGTTTCCTGAAGCACTCTTTGCAAAAGGCTAAACCCAGAGCGGAGAGGAAAGTCAATCTTAATATAATCCGCAAGGAGACCACTGCTGATGGAAAAGAAGAACTAAAAGCAGAAATAGTGCCAGTAGTTATGGCTACTGAAAAACTGGATGAGAGCATTCATCAAAAGCCAGGTGAGAAACTGCAGGCATTGAAATTCAAACTACAGGAGGCAATGAAAGTCCGTCGCATTGAGGAGCGCCAGAAGCGACAAGCCTTATATAAGCTTGACAATGAAGATGGCTTTGAAGATGATGAAGAGGAGGAAGAAATGACAGATGAGTCTGAAGATGATGATAAAAATGCTGAGACTGCAGATTACCTTGGAGAGGAAGATGAGGAAGAGGCTGGTGATGCTGCTGAAGATGAGGATGATACGGGAAATGTGCCTGAAATTGTTGTACCTGTCCCAAGACCAACAGTAACAACAGATTCCACCCTTATGCTGTTTAAGGACAATTCCTCGAAGATAGGAGATTCACTACCTGATGAAAGTGTATGCAAGAGGACCAACAGGCTAGAAGATGAAGACTCCCTGTTACCACAATTAAAAGAAAACAGCCATAATAGCAGCTTTGAACTTATTAGTTCAATGATACCATCATACCAGCCATTTAATAAAACAGCTCGGGGTGTTACCAACTCTAACAATGGCGGCTTTCGCTCACCATCTCCAGTCAATTTTAAAACAAGCTTTCTCAGCTCTGCATCAAAAAGCTCCGGCAAGATGTCCGAACCATCCCTTCCTGTGGAAGATTCACAGGATCTATATAATGCCTCGCCAGAACCCAAAGTCTCATATCTCTGTGCTGGAAGAAGCTCACAATTTCAATTTTCATTGGAAGATGACACCCAGAGCCAACTGCTTGATGCTGATGGTTTTCTGAATGTTGGTCGCCATCAGAGCAAATATAGTTCTGCCAAACACAGGCTAGCATTGGATACAATGGATGAGAATGCTATGGATGCCAACATGGATGAACTACTAGACCTTTGCTCAGGACAGTTCAAAGACTCCATTTCAGGCACATCTCAGGCCACTGAAAAAGAGGCTAAGAAACAGCCAATGGATGAATTGCTTGAATTGTGCTCTGGCAAGTTTGTCTCTCAAGCTGACTGCTCTACACAAGATTCTTCTGCTTCAGCTAAGGACAGTTCCGCAAATGAAAAGAAGGACATGTCTGATGTAGCAGCGCTGGGTTCAAGCTCCTTCCTTGCTGAAAG	Refseq >NM_001088572\|Xenopus laevis claspin (clspn), mRNA ACGCATAGGGCGCGAATTCCAAGGCGGCAGTAGTGAGGATTGGCGGGAGCTGTCATCACCGGGTAGCACCATGGCCGCGCTTTGCGAAGAAGAGCAGGTATTTTTGGAACCAGAAGACATCAGTCTGAAAATTGTGGAGACTGATTCTGACAGTGGTCAAGGCAGCTGTGAAATGGCTGATCAGAATAAATTATTGGGTTGTGTGGAGGATAAAGATACAGATGATGAAATCTTGGTTCGTAAAAAATCTAAAAAGAAGGAAGTATTGGTGGATAGTGACAGTGACGAAGAATTGGAAATGCGTAATTTTGCAGATAATGTAAAGGGGCACTCTGATAATGAGGAGAATGAGGAGACTATGTCTGCTTATAGAGAAAAACCAAGAAAGATCCGTTCAGCTGTATTGGACAGTGACAATAGTGATCATGAGCTTGATGTTCAAATAAGTACAAGTCAAAATGCAGCTGAAATACCTGAGTCAGAACATGATAGCTTGGAGAAGGAAACTCATACTGTGAAGCCTAAAACAAGCAAGTCCTTGAAAAAACAAACTGACACTAATAAAGAGGAAATCGTGAAGAATAAATCAAAGCGCAAAATTCCGAAAGAGAAGATTAAAAGGAGGACAAAACAGAAGTCAAAAGCAGTTGCTGAAGCTAGGCCAAATTTAAATGACAGTGGCTGCTTACTCACAGATGGAGATCTTTTTGACAATGGGGTGGAAAATGAGATGGATTCTAATGAAGAAGAGGATTCTCTTGAAGCTATCCGGGCAAAAATGAAAAGCAAACTGAATAGTCATTCTGCTGAAAATTTTGAAGACTTTGAACTTGATACTGAAGGCAATCAAGAATCCCCAGAAAAAAGAAAGGAACGAAAAGCTGCGCGACTTGGTAAAGAAGCCATGAAACAAATGCACAGTGAGACCCAAAGACTAATACGTGAATCTTCTGTATCTTTACCATATCATCTACCTGAACCAAAAACAATCCATGATTTTTTCAAAAGGCGTCCAAGGCCTCTTTGTCAAGGAAATGCAATGCAGCTTATAAAGTCAACAAAATACCAGCCCTGCACTGAAGAGAAAAAAAAACCCAATGAGGAAATATGTGCTGAAGTTCCAGAGTTTGATTATGTTTCAAAGGAAGATTTAGAAATCAGTCCAGAGCAACCTTTACTAAATACTCAGTGTTCACATGCTGCAGTCCTATGTGTTGTGCAAAATGATGCTCGGACTGAGGGGTTAAGTAAATCCACAGAGGCAGTTGTGACTGGTCAAATGAATGACCATGAGGATGCTTTCAGTGATTCAAACATTGTTCATGAACAAGAAACAGTTGGATTAATAACCGTAACTGAAACCTTTCAGACACCCTTTATTCCCCAACCAGAGAGCGTAGTATGTGAACAAATCCAGAATGATGTAGTAGAGATGCAACGTATGCCTGAACAACCCACGCATAAACCCAAGTTATCCAAGCTTGAAAAGCTGAAAGCTCTTGGAGTGGACTTGTCTATAAAACCTCGCCTTTGCCCTGATGATGGTTCTTTTGTCAACTTGGATGAACCAAAGCCGAATAAAGAATTTGAAGCTTTGAAGGAGCGTTTCCTGAAGCACACTCTGCAAAAGTCCAAACCCAGAACTGAGCGGAAAGTCAATCTTAATATTATCCGCAAGGAGACCACTGCTGATGGAAAAGAAGAACTAAAAGCAGACGTTGTGCCAATAGTTATGGCTACAGAAAAACCAGACAAGAGCATTTATCAAAAGCCAGGTGAGAAGCTGCAGGTATTGAAAGTCAAACTGCAGGAAGCAATGAAAATCCGTCGCAGTGAGGAGCGCCTGAAGCGGCAAGCCTTGTATAAGCTTGACAATGAAGATGGCTTTGAAGATGATGAAGAGGAGGAAGAAATGACAGAGGAGTCTGAAGATGATGGGGATGGAAATGCTGAGACTGCAGATTATCCTGGAGGGGAAGATGAGGAAGAGGTTGGTGATGCTGAAGATGACAATGATGAGGATGATACTGTAAATGATAGATTGTTGGGAAATGTGCCTGAAATTGTTATCCCACTGCCGAGACCAGTAACTACTGATTCTAGCCTCATGCTGTTCAAGGACAATTCTTCAAAGCTAGGAGATTCGCTACCTGATGAAAGTGGATGCAAGAGAAGCAGCAGGCTAGAATATGAAGAAGACTCCCTGTTGCCACAATTAAAAGAAAACAGCCATAATAGTAGCTTTGAACTTATTAGTTCAATGATACCATCATACCAGCCATGTAATAAAACAACTCGAGTTGTGATCAACTCCAATAACCTTGGCTTTCGCTCACCATCTCCGGTTCATTTCAAAACAAGTTTTCTCAGCTCTGCATCAAAGAGTTCTGGCAAGATGTCTGAACCATCCCTTCCCGTGGAAGACTCACAGGATCTATATAATGCTTCCCCAGAGCCCAAAGCCTCATATCTCTGTGCTGGAAGAAACTCTCAATTTCAATTTTCGTTGGAGGATGACACCCAGAGCCAACTGCTTGATGCTGATGGGTTTCTGAATGTTGGTCGCCATAAATCTAGCTCTGCCAAACACAGGCTAGCTTTGGATACAATGGACGAGAATGCTATGGATGCCAATATGGATGAACTACTAGACCTTTGCTCAGGACAGTTCAAAGAATCTCTTTCAGGCACATCACAGGCAGCTGAAAGTGATGCTAAGAAACAACCAATGGATGAATTGCTTGAATTGTGTTCTGGCAAATTTGTATCTCAAGCTGACTGCTCCACACAAGATTCTTCTGCTTCAGCTAAGGACCGTTCTACAGCTGTAAAAAAGGACATTTCTGATGAAGTGGCAACGGTTTCAAGTTCATTCCTTACTGAGAGAGAACAGGAAGAAGATGAGGAAGAAGAATTTGGTGAATTCAAGCTCTTACCCTGTGATGATTCGGAGAGCGAAAACGAAGAACAAAATGAAGAGGAAGAAGAAGAAGAGGATGCTAAGGATGATGAAGATGAGGAAGAAATTTTGCAGAAGCAGCAAAAGAGAAAATTGAGGCTGAATGACTTCATGGAAGATGAAGCCGAATTGTCTGGAAGTGATGTAGGTAGCGGAGATGAGTATGAAGGAGATGATGATGAGTATGAGGAAGAAGCCATAGATGAAGATCTCCCATCTGATGAGGAACTGCAGGATCAAGTCAATAAAATTCATATGAAAGTTACCATGGATGAAGACCAGCGACAGCTTCGTTTCTATCAGGAGCGGTACCTGGCTGATGGGGATCTCCATAGTGACGGACCAGGGAGAACAAGAAAGTTCAGATGGAAACATCTTGATGATGCCTCACAGGTGGACATGTTCCGCCGAGACTCTGAATTGGAAGAGGTGGACGGAGAGAATGAGGAAACTGAGGAAACCGAACTTAAATGGAGGAAAGAGCGGTTCGAAAGGGAACAATGGCTGCGAGAACAGCCACAAGGTAGTAGAGATAACAATGAGGAGGAGGAGGAGGATATTGGAGAAGACAGCCAGTTTATGAAATTGGCAAAGAAGGTCACTGCAAAAGCCCTACAGAGAAAAGTGAGTACAGAGACTAATGAACCAAAGAAACCTGGGCCTAGAAATCCATATGAAGTGATCAGGCCTTTCAGCCTCCCCAAGTTGCGTACTGGTTCGCTGTTAAGCAAACCAAAAGAAGTTTTACAGAAGCTGGCAGCTGTGTCAGACCTGAATCCAAATGCACCTCGAAACTCAAGAAACTTTGTCTTCCAAACTGTCTCACCCGGAAAGAAAGAAGAAACTACAGACAAGCCAAGATCAAAGGTACGAAAGAATATAGCTGTTGCCATGCCTTCCCCTAAACGTTTTAAAAGGGACAGCACCCCTACTGTTAAAAGCCGCAGTATATTTCAGTTGTTGGAGTAGGTTTCTGCGAATATTCCACTAAATCAGTAATTTGTTTTTGTGTCCTAGTTACAGCAAATTCTATATTTTAATGTAGCTGTGCTTACATGCTACAGTTCTCGCTTTACTGAAATTTGTCAGATACTTGAACTAAGTGTTTTTCATCATGAAATTAGTTGTGCTGCATGTTATTCATACAGAGGCATGTGAAATACACTGTGTATTTCTATTGCCTTGTGTCAAATGTTCTACACTTGTTTTGTTCAAAATTACACAAACCGTATCACCTAATGTAAATCTACCTCATAGAGATACAGATACCCTACAAAAATACAGTAATTTTGTTTACAACCACCCATATATTTTGTACTTTGCATTCTTATTCTATTCTCTAAATGTACTCCATTTACAAGTGCTGATTTATAAAGGGGCATTGTACCTATTTGTTCAACACAAGTTCAATTACGTCATGTGCTGAACATGCTCTCCCCCCCATCTTAAAATATGTTTTTCTTATGAATTGCATTAAACAGGGCAAACACTGAAACTATAAGTTTATGGGAGTGCTGGTAAAAACAACAACCTATTAGTGCTTTATAATATAAAAAATTAGGTTATTATATGGATTGTTTTTAATTAAAACAATAAGCAGAACAAATTTAAAACAAGTCCTATTTATTTTGCTCATGTTAAATAAAAGTGTATATATCCATATACTACCCGTTTAAACTGTGTAATGAATGTGTTTCTTGTAATATATTTTATTGTACATTGTTATAAATGTTTGTGAGATTTGTTAATAAATACATTTTTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002938885\|PREDICTED: claspin, partial [Xenopus (Silurana) tropicalis] MAALCEEEQLVLEPEDSISLKILETDSDSGQGSCEMASADDQNKILDCIEDRDTDEEEFLVCKKSKSKKILVESDSDEEMETSKIADNVKGNSKNDEENNISAHREKPRRIQSALFDSDNSDNEVDVQMSTRQNTIERPESDHGSLEKESPTVKHKTSKSLKKQGDTNKEKRVKNKSKHKIQKEEKVKRRTQQKSKAVKEDRPNLNDSGCLLNGDLFENEVGSGVDSNEEEESLDAIRTKIKGKLNSHSTEDYEGFELETEGMQETQEKRKERKAARLGKEAMKQMHSETQRLMRESSVSLPYHLPEPKTIHDFFRRRPRPLCQGNAMHLIKSTKYQPCTEEKKNTKEEICAEVQKGDYVSKEDLEISEENNLLNPQCSHAAALLDVQKDAHTEGISKSTETVVNGEINENLIQLDKEDTFNHNNNVHKQEAVGLIAVNEIFQSPSILQPESTVCEQIQNNVDSNLMPEQPLHKPKLSKLEKLRALGVDLSIKPRLCPNDGSFVNLDEPKPNKEFEALKERFLKHSLQKAKPRAERKVNLNIIRKETTADGKEELKAEIVPVVMATEKLDESIHQKPGEKLQALKFKLQEAMKVRRIEERQKRQALYKLDNEDGFEDDEEEEEMTDESEDDDKNAETADYLGEEDEEEAGDAAEDEDDTGNVPEIVVPVPRPTVTTDSTLMLFKDNSSKIGDSLPDESVCKRTNRLEDEDSLLPQLKENSHNSSFELISSMIPSYQPFNKTARGVTNSNNGGFRSPSPVNFKTSFLSSASKSSGKMSEPSLPVEDSQDLYNASPEPKVSYLCAGRSSQFQFSLEDDTQSQLLDADGFLNVGRHQSKYSSAKHRLALDTMDENAMDANMDELLDLCSGQFKDSISGTSQATEKEAKKQPMDELLELCSGKFVSQADCSTQDSSASAKDSSANEKKDMSDVAALGSSSFLAE	Refseq >NP_001082041\|claspin [Xenopus laevis] MAALCEEEQVFLEPEDISLKIVETDSDSGQGSCEMADQNKLLGCVEDKDTDDEILVRKKSKKKEVLVDSDSDEELEMRNFADNVKGHSDNEENEETMSAYREKPRKIRSAVLDSDNSDHELDVQISTSQNAAEIPESEHDSLEKETHTVKPKTSKSLKKQTDTNKEEIVKNKSKRKIPKEKIKRRTKQKSKAVAEARPNLNDSGCLLTDGDLFDNGVENEMDSNEEEDSLEAIRAKMKSKLNSHSAENFEDFELDTEGNQESPEKRKERKAARLGKEAMKQMHSETQRLIRESSVSLPYHLPEPKTIHDFFKRRPRPLCQGNAMQLIKSTKYQPCTEEKKKPNEEICAEVPEFDYVSKEDLEISPEQPLLNTQCSHAAVLCVVQNDARTEGLSKSTEAVVTGQMNDHEDAFSDSNIVHEQETVGLITVTETFQTPFIPQPESVVCEQIQNDVVEMQRMPEQPTHKPKLSKLEKLKALGVDLSIKPRLCPDDGSFVNLDEPKPNKEFEALKERFLKHTLQKSKPRTERKVNLNIIRKETTADGKEELKADVVPIVMATEKPDKSIYQKPGEKLQVLKVKLQEAMKIRRSEERLKRQALYKLDNEDGFEDDEEEEEMTEESEDDGDGNAETADYPGGEDEEEVGDAEDDNDEDDTVNDRLLGNVPEIVIPLPRPVTTDSSLMLFKDNSSKLGDSLPDESGCKRSSRLEYEEDSLLPQLKENSHNSSFELISSMIPSYQPCNKTTRVVINSNNLGFRSPSPVHFKTSFLSSASKSSGKMSEPSLPVEDSQDLYNASPEPKASYLCAGRNSQFQFSLEDDTQSQLLDADGFLNVGRHKSSSAKHRLALDTMDENAMDANMDELLDLCSGQFKESLSGTSQAAESDAKKQPMDELLELCSGKFVSQADCSTQDSSASAKDRSTAVKKDISDEVATVSSSFLTEREQEEDEEEEFGEFKLLPCDDSESENEEQNEEEEEEEDAKDDEDEEEILQKQQKRKLRLNDFMEDEAELSGSDVGSGDEYEGDDDEYEEEAIDEDLPSDEELQDQVNKIHMKVTMDEDQRQLRFYQERYLADGDLHSDGPGRTRKFRWKHLDDASQVDMFRRDSELEEVDGENEETEETELKWRKERFEREQWLREQPQGSRDNNEEEEEDIGEDSQFMKLAKKVTAKALQRKVSTETNEPKKPGPRNPYEVIRPFSLPKLRTGSLLSKPKEVLQKLAAVSDLNPNAPRNSRNFVFQTVSPGKKEETTDKPRSKVRKNIAVAMPSPKRFKRDSTPTVKSRSIFQLLE UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.1621 [+] Str.6391	Xl.696
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		5 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	CLSPN
mouse		MGI	Clspn	All(3) Targeted, other(2) Targeted, knock Out(1)
zebrafish

Publications
First:		Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. [Mol Cell 2000]
Most recent:		The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. [Mol Biol Cell 2013]
		View All Papers

Functional Ontologies
GO: Molecular:		exo-alpha-sialidase activity
Biological:
Cellular Component:
EC:		exo-a-sialidase
KOG:		[DT] Claspin, protein mediating phosphorylation and activation of Chk1 protein kinase in the DNA replication checkpoint response

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.1621.1.S1_at [+] Str.36596.1.A1_x_at Str.6391.1.S1_at	Xl.696.1.S1_at
Affymetrix 2.0			Xl2.696.1.S1_at

Symbol legend[+]