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Summary Expression Gene Literature (7) GO Terms (15) Nucleotides (297) Proteins (45) Interactants (150) Wiki
XB-GENEPAGE-491635
Gene Symbol:
sesn1

Gene Name:
sestrin 1

Synonyms:
nuclear factor XPA26-T2 , XPA26 , PA26 ( Add synonyms , Nomenclature history )

Gene Function:
Uncharacterized conserved protein

Protein Function :
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TO...[+]



Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-491636 XB-GENE-866080 XB-GENE-17336241
Gene Symbol sesn1 sesn1.L sesn1.S
Chromosome Chr05 chr5L chr5S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100170187
379559
108717942
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq RefSeq Swiss-Prot Swiss-Prot NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine sesn1 sesn1.L sesn1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SESN1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Sesn1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Sesn1 Ensembl
zebrafish
ZFIN, AGR sesn1 ZFIN Ensembl
chicken
GEISHA SESN1 Ensembl
fruit fly
worm
Publications
First A Xenopus homolog of a human p53-activated gene, PA26, is specifically expressed in the notochord., Mech Dev 2001    
Most Recent Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles., Sci Rep 2020                    
All View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 13 terms 6 terms 0 term
PANTHER sesn1
KEGG Pathways K10141 K10141
KOG [S] Uncharacterized conserved protein (alt_id KOG:3746)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks sesn1
ORFs sesn1.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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