lrrk2 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Nucleotides (124)

Interactants (0)

XB-GENEPAGE-5768571

[provisional- machine annotated only] Gene Symbol: lrrk2 [Predicted: Source is Human Entrez Gene] Gene Name: leucine-rich repeat kinase 2 [Predicted: Source is Human Entrez Gene] Add Xenopus synonyms Gene Function: tyrosine kinase Interactants:

XB-GENE-5768572

XB-GENE-6252262

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >BC158475\|Xenopus tropicalis hypothetical protein LOC100145062, mRNA (cDNA clone IMAGE:7698773), partial cds GGCCAGGTTGTAGACCATATAGATTCTCTGATGGAGGAATGGTTTCCAGGTCTACTTGAGTCTGGTATTTGTGAGGAAGGTGAAGCGCTTTTAAAAAAATGGGTACTATACAGCTTTGATGATGGCCAAGAACACAAAAAAATATTGCTGTCTGACTTGCAGGCAAAAGCAGAAGAAGGAGATTTGTTGGTAAATCCTGAGGATCCAAGACAAACCATTCCTGTCTCCCAGATTGCACCTGACATTGTGTTGGCTGACCTTCCTAGAAATATTATGTTAAATGCTGAAGAACTGGAATTTGATCAGGCTCCTGAATTTCTACTGGGGGATGGAGGGTTTGGATCGGTGTATAGAGCATCATACAAAGGAGAAGATGTAGCTGTGAAAATTTTTAACAAACACACTTCTTCAAGGCTTTTAAGACAGGAGCTTACTGTTCTCAGTCACCTTCATCATCCTAGCTTGGTGTGTTTGTTAGCAGCTGGAGTACATCCAAGAATGTTAGTTATGGAACTTGCACCTAAAGGCTCTCTGGATCATCTCCTGCAGCAAGACTGTGCCAGCCTCACAAGAACTCTTCAGCACCGGATAGCTCTGCATGTAGCTGATGGACTAAGGTATCTCCATTCAGCCATGATCATATACCGTGATTTAAAGCCTCACAATGTCCTGCTTTTTACTCTGTATCCTAACTCTGCAATTATAGCAAAGATTGCAGACTATGGAATTGCACAGTACTGTTGCAGAATGGGTATCAAAACATCTGAAGGTACACCTGGATTTCGGGCACCTGAAGTTGCTAGAGGAAATGTTATTTACAACCAGCAAGCTGATGTCTATTCGTTTGGGTTGCTTCTATATGACATTCTAACAGGTGGAGCCCGGATGGTAGAAGGTCTGAAATTTCCAAATGAATTTGATGAGTTGGCAATTCATGGAAGATTACCTGATCCAGTCAAAGAATATAATTGTGCTCCTTGGCCTGAAGTTGAAGTATTGATTAAAAAATGTTTAAAAGAAAATCCCCAGCAACGTCCCACATCTGCCACGGTATATGAGATCTTAAACTCAGCAGAACTACTCTGTTTAATGAGGAACATTGTGATATTCAGTATGTTAACAGCAGAATGCATGGTGGCTGCCAGTCCTCTTGTCAAGAAGCATGCTGTTTGGGTAGGAAACGGCAGCACAAGAAAGGGACAGATGTGCTGTATAGATTTAAATAAAGGTGGACAAACATGTGAGGACTTTTCGGACAGCCGAATCTTATGCCTTACACTAGTCACATTACCTGGAGAGAAACAAAGCTGGATTTTGGCTGGAACTCAGTCTGGAGAAATTATAGCTGCAGATTCAGAAGATCTTAAGATAAAACACACTCTGCATAAATTGACAGATTCTGTTACTTGCTTGTTGTTCTCATGTATCCAGGGAGAGAGCCCAAAGAAATATTACATTCTAGCAGGTACTGCAAACGGCCGTGTAGCAGTTTTTGAGAATACTGCAGTTAAGTGTACAGATGCTGCACCTATGAAGGTGATCAACATTGGTGATAGCAGCACTCCAGTGATGCATTTGTGTGAATCCACTTATTCATCTGAAAAAAAATCAGTCTGGGGTATCTGTGGGACAAAGATTTTCTCACTTTCTAGTGAATTCACTGTACAAAAGACAATTGATACCAGAGTTGCCACACTGTATTCCCACGGCTCATACAGTGAATCCAATATCACATGCATTGCGATTGACAAATACATCTATGTAGCAAAAAAAAAAAAAAA	NCBI Nucleotide >BC076853\|Xenopus laevis hypothetical protein LOC445832, mRNA (cDNA clone IMAGE:6637919), partial cds GATTGCGCCTGACATTGTGCTGGCAGACCTTCCTAGAAATATTATGTTAAATGCTGAAGAACTGGAATTTGATCAGGCTCCTGAATTTTTGCTGGGGGATGGAGGGTTTGGATCGGTGTATAGAGCATCGTACAAAGGCGAAGATGTAGCTGTGAAAATTTTTAACAAACATACTTCTTCAAGGCTTTTAAGACAGGAACTTACAGTCCTTAGTCACCTTCATCATCCTAGCTTGGTGTATTTGTTAGCGGCTGGAGTACATCCAAGAATGTTAGTTATGGAACTTGCACCTAAAGGCTCTCTGGATCATCTCCTGCAGCAAGACAGCGCTAGCCTCACAAGAACTCTCCAGCACCGGATAGCTCTGCATGTAGCTGATGGACTAAGGTACCTTCATTCAGCCATGATTATATACCGTGATTTAAAGCCTCATAATGTCCTTCTTTTTACTCTGTATCCAAACTCGGCAATTATTGCAAAAATTGCAGACTATGGAATTGCACAGTACTGTTGCAGAATGGGTATTAAAACCTCTGAGGGTACCCCAGGATTTCGGGCACCTGAGGTTGCTAGAGGAAACGTTATCTACAACCAGCAGGCTGATGTCTATTCATTTGGGTTGTTGCTGTATGACATTCTGACAGGTGGAGCCCGCATGGTGGAAGGTCTGAAATTTCCAAATGAATTTGATGAGTTGGCAATTCATGGAAGATTACCTGATCCAGTCAAAGAATATAATTGTGCCCCTTGGCCTGAAGTTGAAGTATTGATTAAAAAGTGTTTAAAAGAAAATCCCCAGCAACGTCCTACATCTGTCACGGTATACGAGATCTTAAACTCAGCAGAACTACTCTGTTTAATGAGAAACCATGTGATATTCAGTATGTTAACAGCAGAATGCATGGTGGCTGCCAGTCCTCTTGTCAAGAAGCATGTTGTTTGGGTAGGAAATGGCTGCACTGAAAAGGGACAGATGTGCTGTATCGATTTAAATAAAGGTGGACAAACGTGTGAGGATTTTTCGGACAGCAGAATCTTATGCCTTACACTAGTCACATTACCCGGAGAGAAACAAAACTGGATTGTGGCTGGAACTCAGTCTGGAGAAATTATAACTGCAGATTTAGACGAACTTAAAATAAAACACACTCTGCATAAATTGACAGATTCTGTTACATGTTTGTTGTTCTCGTGCATCCAAGGACAGAGCCAAAAGAAATATCACATTCTAGCAGGTACTGCAAATGGCCGAATAGCAATTTTTGAAAATACTGCAGTAAAGTGTGCATATGCTGCACCAATAAAGGTGATCGACATTGGTGATAACAGCACTCCTGTAATGTGTCTGTGTGAATCCACTTATTCATCTGAAAAGAATTCAGTCTGGGGTATCTGTGGGACAAAGATTTTCTCACTTTCTAGTGAATTCACTGTACAAAAGACAATTGATACCAGAACTGCCACACTGTATTCTCATGGCTCATACAGCGAATCCAATATCACATGCTTTGCGATTGACAAATACATTTATGTGGCAAAGAAAATCAGTCCCTATGTAGAAATATGGGACAAGAAGACAGAAAAAATATGTGAAGTCCTTGATTGTGTCCAGTTCCTGAAAGAAGATAGCAGGAAGAGAAGAAAATGTAAACAGGAAGAAGCTTATACTTCACGAGTAAAAGCTTTATATTTGCAAAAAAATACTGCTCTTTGGGTAGGAACTGGGGGAGGCCATATTCTGTTAATTGACTTATCAACTCGTCAACCAATACGAATAATCACAAGCTTCTGCGATTCTATTCGAAGTATGGTGCCTGCACAGTTAGACAGAGGAAGTATAAAGAATGTTGTGCTTGTTTTGGGATGTCGGTGCACACCACAAAAAGAGATACAATCATTTCTCTCTGTCTGGGATACTAACCTTCCACATGAGGTCCAGAATCTTAAAAAACACAATGAAATCAGACAAGAATTTGCTGATAAACTGAGAGGATTATCAATGGACTAATGAATAATCGGTATAGGGAATTCGGAGTATAATTAAAAGCTTGGCCTAATCACTGCTCTAAAGAGGATTTAATTAAGAACTCTTCCAAATGAGTACAGCGATGGAGCTCATACATCGTTGGATTATGTACCACTTTTATTCCGAGTTGTTTTTTTAATAGATTGCATTTTACTGATTTTTTGTTCTGGGCTGCCTGATCTAAGATTCCTAATATTATTTATCTGTTAAATGTTGGGTATCCATCCTCATTGCCTTTGAACCAGGCATTGTGCTTTCAACCTCCTTGCCTGCCTTTATAGCTATTTTTACTTACATCTTAAAATGCAATTTGCTGTTTTAATAAGTAATGTTTACCAGTTTATTTAACCATAAAAAGAGGCTATAGATATAGAACATGCCACCTATATTTTAATTCATATGTGAGAGTTAAAGTTACAATATTGCCACAAGTAGGACCAACCAACAAAATGTTTAATTAAAGCAGTATGGGCAGTATTTTATCTCCAATTTCTGTAGTGCATGCTTATACAAAGAGAAAAAAATGTTCTTGGTCCTTTTAAAGCTGCTATTGCATGCTTGTACAGTGGCGTAACTATAGCAGAAGCAGACCCCAAGGCTTGGGGGGGGGGGGCATTCCAGGAAGGGAGGTATCAGAATGGGCGGGAAGTAGGTGGGAGGGATTGCCGTGTGCCAGGCCCCTATGAAGACTTTTTTTTATAGCTGGGGACCCTGGCGCACACCAGTTACGCCACTGTGCTTCCACATCTGTTTTAGAGCAAATGACTAGAACACTAATGTCCCTTACATGAAGTTCTGGTCATTTAAACACTCAAAATGTATTTATAATCCAAAGACTGAAACTTTTAAAAACATTGGTCAACAAAGTGAAGTACAGTATGTATTGAGTTTAATCCAGTTTTTATGCAGAATATTTTAACTGTGCATGCACACACACGCACTTAGGGGCGTATGTATTATGTTGTGTAAAAGGAAATTTTCCAAAAAAAATGGTGTAAAAATCTGCATAAAATAAATGGTGAATTTCTCAAGGTGTGTTTAATTTTATGCCTCGCAAACCCCAGATTTGCCTCTGTTCTTTTACATTGCTTCAGATGGAAGAAACAAAAACGCATAAAAAAATGATGGCGTTTTTTTACACAGCAACGTCTGGTGATATGTGGTGTATTATCCCACCATTTTTACACAGCATAATAAATATACAGCTTAGAGACATAACCCTGCAATGCTGCTGGATGGTTTTGGGGGGAGGTGTTTAAAAAAATAAAATAAAACTGTGCATATAACTGTAAAATATAATAGCAATTTTTCATATGTCAGTTCTGTGTTTTTACCCTTAATGTTAAATGGACATTTTTATTTAGACATCTGCAATAAAAAGTAAATACTGAAAAAAAAAAAAAAA
Protein		NCBI Protein >AAI58476\|LOC100145062 protein [Xenopus (Silurana) tropicalis] GQVVDHIDSLMEEWFPGLLESGICEEGEALLKKWVLYSFDDGQEHKKILLSDLQAKAEEGDLLVNPEDPRQTIPVSQIAPDIVLADLPRNIMLNAEELEFDQAPEFLLGDGGFGSVYRASYKGEDVAVKIFNKHTSSRLLRQELTVLSHLHHPSLVCLLAAGVHPRMLVMELAPKGSLDHLLQQDCASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNSAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTGGARMVEGLKFPNEFDELAIHGRLPDPVKEYNCAPWPEVEVLIKKCLKENPQQRPTSATVYEILNSAELLCLMRNIVIFSMLTAECMVAASPLVKKHAVWVGNGSTRKGQMCCIDLNKGGQTCEDFSDSRILCLTLVTLPGEKQSWILAGTQSGEIIAADSEDLKIKHTLHKLTDSVTCLLFSCIQGESPKKYYILAGTANGRVAVFENTAVKCTDAAPMKVINIGDSSTPVMHLCESTYSSEKKSVWGICGTKIFSLSSEFTVQKTIDTRVATLYSHGSYSESNITCIAIDKYIYVAKKKK	NCBI Protein >AAH76853\|LOC445832 protein [Xenopus laevis] IAPDIVLADLPRNIMLNAEELEFDQAPEFLLGDGGFGSVYRASYKGEDVAVKIFNKHTSSRLLRQELTVLSHLHHPSLVYLLAAGVHPRMLVMELAPKGSLDHLLQQDSASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNSAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTGGARMVEGLKFPNEFDELAIHGRLPDPVKEYNCAPWPEVEVLIKKCLKENPQQRPTSVTVYEILNSAELLCLMRNHVIFSMLTAECMVAASPLVKKHVVWVGNGCTEKGQMCCIDLNKGGQTCEDFSDSRILCLTLVTLPGEKQNWIVAGTQSGEIITADLDELKIKHTLHKLTDSVTCLLFSCIQGQSQKKYHILAGTANGRIAIFENTAVKCAYAAPIKVIDIGDNSTPVMCLCESTYSSEKNSVWGICGTKIFSLSSEFTVQKTIDTRTATLYSHGSYSESNITCFAIDKYIYVAKKISPYVEIWDKKTEKICEVLDCVQFLKEDSRKRRKCKQEEAYTSRVKALYLQKNTALWVGTGGGHILLIDLSTRQPIRIITSFCDSIRSMVPAQLDRGSIKNVVLVLGCRCTPQKEIQSFLSVWDTNLPHEVQNLKKHNEIRQEFADKLRGLSMD

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.38502	Xl.48462
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	LRRK2	OMIM:607060
mouse		MGI	Lrrk2	All(14) Targeted, knock Out(9) Targeted, other(2)
zebrafish		ZFIN	lrrk2	1 Lines(s)

Publications
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Most recent:
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Functional Ontologies
GO: Molecular:		3-phosphoinositide-dependent protein kinase activity AMP-activated protein kinase activity ATP binding More[+] DNA-dependent protein kinase activity G-protein coupled receptor kinase activity GTP binding IkappaB kinase activity JUN kinase activity JUN kinase kinase activity JUN kinase kinase kinase activity Janus kinase activity MAP kinase 1 activity MAP kinase 2 activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP/ERK kinase kinase activity MP kinase activity NF-kappaB-inducing kinase activity SAP kinase activity atypical protein kinase C activity cGMP-dependent protein kinase activity calcium-dependent protein kinase C activity calmodulin-dependent protein kinase activity casein kinase I activity casein kinase activity cobinamide kinase activity cyclic nucleotide-dependent protein kinase activity cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein kinase activating kinase regulator activity cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity diacylglycerol-activated phospholipid-dependent protein kinase C activity elongation factor-2 kinase activity eukaryotic elongation factor-2 kinase activator activity eukaryotic elongation factor-2 kinase regulator activity eukaryotic translation initiation factor 2alpha kinase activity galactosyltransferase-associated kinase activity glycogen synthase kinase 3 activity multifunctional calcium- and calmodulin-regulated protein kinase activity non-membrane spanning protein tyrosine kinase activity phenol kinase activity phosphatidylinositol phosphate kinase activity phosphofructokinase activity phosphoinositide 3-kinase activity phosphorylase kinase activity phosphorylase kinase regulator activity phosphotransferase activity, alcohol group as acceptor protein kinase C activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein serine/threonine kinase activity receptor signaling protein tyrosine kinase activity ribosomal protein S6 kinase activity transmembrane receptor protein kinase activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation protein transport small GTPase mediated signal transduction
Cellular Component:
EC:		Phosphotransferases with an Alcohol Group as Acceptor
KOG:		[T] Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.52080.1.S1_at [+] Str.38502.1.A1_at
Affymetrix 2.0			Xl2.48462.1.S1_at

Symbol legend[+]