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bdnfxenopus neural nucleus 

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Experiment details for bdnf

The cellular patterns of BDNF and trkB expression suggest multiple roles for BDNF during Xenopus visual system development.

The cellular patterns of BDNF and trkB expression suggest multiple roles for BDNF during Xenopus visual system development.

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Gene Clone Species Stages Anatomy
bdnf.L laevis NF stage 40 neural nucleus

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  FIG. 1. Onset of BDNF expression in the developing optic tectum. In situ hybridization with a digoxygenin-labeled antisense BDNF probe shows specific alkaline phosphatase reaction signals over the cytoplasm of midbrain cells of stage 40 and 45 tadpoles. (A) Transverse cryostat section at the level of the rostral midbrain of a stage 40 tadpole shows weak digoxygenin-positive cell bodies in dorsal and ventral midbrain cells. (B) An adjacent section to that in A, hybridized with a sense control BDNF probe shows no signal. (C) Sagittal section of a stage 40 tadpole reveals that the highest BDNF-expressing cells are localized to the ventral part of the rostral midbrain, presumably in the developing ventral mesencephalic nuclei (vmn). (D) Hybridization of a stage 45 tadpole with the antisense BDNF probe shows specific hybridization in ventral mesencephalic nuclei (vmn) as well as in dorsolateral cells laying in close proximity to the tectal neuropil (np). (E) Hybridization of a stage 45 transverse section at the level of the rostral midbrain with a sense control BDNF probe shows no signal. D, diencephalon, M, mesencephalon; me, melanocyte; R, rhombencephalon; T, telencephalon. Dorsal is up, ventral is down. Scale bar, 50 mm.
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