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bdnfxenopus optic tectum 

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Experiment details for bdnf

The cellular patterns of BDNF and trkB expression suggest multiple roles for BDNF during Xenopus visual system development.

The cellular patterns of BDNF and trkB expression suggest multiple roles for BDNF during Xenopus visual system development.

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Gene Clone Species Stages Anatomy
bdnf.L laevis NF stage 45 optic tectum

  FIG. 2. Expression of BDNF mRNA in the developing diencephalon and optic tectum, and its relation with projecting and arborizing optic nerve fibers. Transverse cryostat sections of stage 45 tadpoles hybridized in situ with an antisense BDNF probe (A, C, E) are compared with equivalent sections of sibling embryos in which optic nerve fibers were anterogradely labeled from the retina with the lipophylic dye, DiI (B, D, F). (A) A transverse� oblique section at the level of the optic tract (B; arrowhead) shows digoxygenin-positive cell bodies over dorsomedial, dorsolateral, as well as ventromedial cellular diencephalic regions. (C�F) Hybridization of transverse cryostat sections at the level of the developing optic tectum shows individual digoxygenin-positive cell bodies that lay dorsolaterally (C, E), in close proximity to the tectal neuropil (np). Note that cell bodies are all restricted to the central gray matter region, while DiI fiber labeling is restricted to the neuropil formed of arborizing optic nerve fibers (D, F; diffuse DiI label) and mesencephalic neuritic processes (G; retrogradely labeled with biotin�dextran). High BDNF-expressing cell bodies also localize to the ventral mesencephalic nuclei (C), just dorsal to the infundibulum (if). (E�G) High-magnification photomicrographs at the level of the optic tectum show some intensely stained digoxygenin-positive cell bodies (E; black arrow) that lay in close proximity to branching retinal arbors (F; white arrow). As seen by the retrograde label with biotin�dextran, this population of tectal cells project their dendrites (G; arrowhead) to the tectal neuropil, where RGC axons arborize. Dorsal is up, ventral is down. Scale bar, 50 mm.
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