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bmp4xenopus joint 

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Experiment details for bmp4

Joint development in Xenopus laevis and induction of segmentations in regenerating froglet limb (spike).

Joint development in Xenopus laevis and induction of segmentations in regenerating froglet limb (spike).

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Gene Clone Species Stages Anatomy
bmp4.L laevis NF stage 59 joint
bmp4.L laevis NF stage 59 joint

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  Figure 3. Expression patterns of bmp-4, gdf-5, and sox-9 during hindlimb development. A,B: Bmp-4 expression in Xenopus st52 hindlimb bud. Section revealed that bmp-4 was expressed in both proximal and distal regions (A). Bmp-4 was also expressed in the distal region (B). C: In st54 limb bud, bmp-4 was expressed in the interdigital regions. D: The section of the st54 hindlimb bud revealed the expression in perichondrial cells surrounding the skeletal element. E: Higher magnification of the boxed region in D. F,G: In st59 hindlimb, bmp-4 was expressed in the joint region (F,G, arrows) and the perichondrium (F, arrowheads). Bmp-4 expression was detectable in the digit-joint region, that is, before the differentiation into three layers (G, arrowheads). H-L: Gdf-5 expression in the developing hindlimb bud. In st52 hindlimb bud, gdf-5 was expressed at low levels in the posterior region, which was similar to the expression of bmp-4 (H). In the st53 hindlimb bud, gdf-5 expression was detectable in the autopodium (I). Gdf-5 expression was restricted to the joint region (J). In the st58 hindlimb bud, clear signals of gdf-5 expression were detectable in the joint region (K). The section revealed that the expressions were restricted to the joint region and also slightly detectable in chondrocytes (L). M: Sox-9 was strongly expressed in chondrocytes. The sox-9 expression was detectable broadly from the distal to proximal regions. N: In the st55 hindlimb bud, sox-9 expression in the presumptive joint region was decreased (arrows). Scale bar = 200 mu m.
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