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bmp4xenopus blastema 

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Experiment details for bmp4

Joint development in Xenopus laevis and induction of segmentations in regenerating froglet limb (spike).

Joint development in Xenopus laevis and induction of segmentations in regenerating froglet limb (spike).

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Gene Clone Species Stages Anatomy
bmp4.L laevis NF stage 57 to NF stage 58 blastema

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  Figure 4. Expression of bmp-4, gdf-5, and sox-9 in regenerating froglet blastema. A-C: Middle stage of a blastema. Bmp-4 expression was detectable in the distal region of the blastema (A, arrowheads). A′: Higher magnification of A. Bmp-4 was expressed in the mesenchyme beneath the epidermis. Gdf-5 expression was also observed in the region corresponding to bmp-4 expression (B, arrowheads). B′: Some signals of gdf-5 transcription were present not only beneath the epidermis but also in the interior. Sox-9 was expressed in chondrocytes (C,C′). D–F: Late stage of a blastema. Arrowheads point to several bmp-4 expressing cells (D,D′). Note the “salt and pepper” pattern characteristics of the bmp-4 signal. The accumulation of bmp-4 expressing cells was not detectable in the peripheral region of the cartilage. In the peripheral region of the cartilage, bmp-4 was expressed sparsely (D′). E: Gdf-5 expression in the late stage of blastema. E′,E′: Higher magnifications of E. In many cases, blastema consisted of some cartilage elements. The blastema expressed Gdf-5 in the boundaries of each element (E,E′, arrowheads), which expressed sox-9 (F). Gdf-5 was also expressed in the proximal cartilage (E, E′, arrows). Scale bar = 500 μm (A′,B′,C′,D′,E′,E′) and 100 μm (A–F).
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