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dlx5xenopus anterior hypothalamus 

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Experiment details for dlx5

Papalopulu N and Kintner C (1993) Assay

Xenopus Distal-less related homeobox genes are expressed in the developing forebrain and are induced by planar signals.

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Gene Clone Species Stages Anatomy
dlx5.L laevis NF stage 37 and 38 anterior hypothalamus

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  Fig. 5. Expression pattern of X-dll3 and 4 in sections of Xenopus tadpoles, after whole-mount in situ hybridization. Serial sections through the brain of a stage 37 tadpole after in situ hybridization with a X-dll3 probe (A-E) or an X-dll4 probe (F-G). The plane of sectioning and the A-P level of the sections shown is approximately the same between A-E and F-G and is indicated by arrowheads in T, superimposed on whole-mount in situ hybridization of a stage 37 brain with X-dll3. For definition of the A-P and D-V axis see Fig. 6. In A and F, an arrowhead points to the dorsal limit of expression in the telencephalon. In B and C, arrowheads point to the ‘segment-like’ expression of x-dll3 in the ventral thalamus. The upper arrowhead marks the sulcus medius (unlabelled) that separates the dorsal from the ventral thalamus. Note however, that expression continues ventrally in more posterior sections, into the anterior hypothalamus (B,C and D for X-dll3, and G, H and I for X-dll4). In E and J, arrowheads point to restricted punctate expression in the posterior hypothalamus. (N,S) Sections that also show the restricted expression of X-dll3 (N) and X-dll4 (S) in the posterior hypothalamus at a level more posterior to that shown in E and J, and at slightly older embryos (stage 39). The sections shown in E, J, N and S, pass though the punctate ‘line’ of expression that is indicated by an arrow in T and by arrowheads in O. (O) Parasagittal section though a stage 37 brain hybridized with x-dll3 (the same result was obtained with X-dll4; data not shown) In O also note that there is non-expressing ‘band’ of tissue between the telencephalon and diencephalon (unlabelled), which is presumably the tel-diencephalic boundary. Although Xdll3 and X-dll4 appear to have the same A-P and D-V limits of expression within the neural ectoderm, they differ in that X-dll3 is expressed more medially than Xdll4, as can be seen by comparing the mediolateral limit of expression (arrow) between B (X-dll3) and G (X-dll4), or between C (X-dll3) and H (X-dll4). They also differ in their expression in the sense organs in that X-dll3 is expressed in the olfactory placode (A and B), the otic vesicle (K) but not in the eye (L), while X-dll4 is not expressed in the olfactory placode (F,G), and the otic vesicle (P), but is expressed in the eye (arrowhead in Q). Both genes are expressed in the branchial arch neural crest, shown in M for X-dll3 and R for X-dll4, but X-dll3 is expressed strongly only in the distal part and shows a sharp proximodistal boundary (indicated by arrows in M). Note that the neural crest envelopes a core of nonexpressing mesodermally derived muscle cells. Abbreviations: ch, optic chiasma; cg, cement gland; ddi, dorsal diencephalon; di, diencephalon; dt, dorsal telencephalon; Et, epithalamus; e, eye; Ht, hypothalamus; hy, hypophysis; Tv, ventral thalamus; Td, dorsal thalamus; me, mesencephalon; m, muscle; nc, neural crest; on, optic nerve; op, olfactory placode; os, optic stalk; ov, otic vesicle; ph, pharynx; vdi, ventral diencephalon; vt, ventral telencephalon.