|
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf4
|
|
tropicalis
|
NF stage 10.5
|
mesoderm
,
marginal zone
|
fgf4
|
|
tropicalis
|
NF stage 15
|
mesoderm
,
posterior
|
fgf4
|
|
tropicalis
|
NF stage 23
|
somite
,
tail bud
,
eye primordium
,
paraxial mesoderm
|
fgf4
|
|
tropicalis
|
NF stage 28
|
otic vesicle
,
midbrain-hindbrain boundary
,
somite
,
branchial arch
,
tail bud
,
[+]
|
fgf4
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
midbrain-hindbrain boundary
,
somite
,
branchial arch
,
tail bud
,
[+]
|
fgf4
|
|
tropicalis
|
NF stage 40
|
otic vesicle
,
midbrain-hindbrain boundary
,
head region
,
somite
,
branchial arch
,
[+]
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf2
|
|
tropicalis
|
NF stage 10.5
|
mesoderm
,
marginal zone
|
fgf2
|
|
tropicalis
|
NF stage 15
|
paraxial mesoderm
|
fgf2
|
|
tropicalis
|
NF stage 23
|
head region
,
presomitic mesoderm
|
fgf2
|
|
tropicalis
|
NF stage 28
|
head region
,
presomitic mesoderm
,
eye
|
fgf2
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
neural crest
,
mesoderm
,
branchial arch
,
tail bud
,
[+]
|
fgf2
|
|
tropicalis
|
NF stage 40
|
otic vesicle
,
head mesoderm
,
branchial arch
,
tail bud
|
fgf8
|
|
tropicalis
|
NF stage 10.5
|
marginal zone
|
fgf8
|
|
tropicalis
|
NF stage 15
|
neuroectoderm
,
pre-chordal neural plate
,
neural crest
,
neural plate
,
cranial neural crest
,
[+]
|
fgf8
|
|
tropicalis
|
NF stage 23
|
forebrain
,
midbrain-hindbrain boundary
,
neuroectoderm
,
neural crest
,
presomitic mesoderm
,
[+]
|
fgf8
|
|
tropicalis
|
NF stage 28
to
NF stage 35 and 36
|
forebrain
,
midbrain-hindbrain boundary
,
head region
,
mesoderm
,
somite
,
[+]
|
fgf8
|
|
tropicalis
|
NF stage 40
|
otic vesicle
,
forebrain
,
midbrain-hindbrain boundary
,
somite
,
pharyngeal arch
,
[+]
mandibular arch
,
hyoid arch
,
branchial arch
,
tail bud
,
chordoneural hinge
,
posterior wall of neurenteric canal
,
eye
,
paraxial mesoderm
,
heart primordium
,
pronephric kidney
,
neural tube
|
fgf1
|
|
tropicalis
|
NF stage 10.5
|
marginal zone
|
fgf1
|
|
tropicalis
|
NF stage 15
|
embryo
,
dorsal
|
fgf1
|
|
tropicalis
|
NF stage 23
|
notochord
,
eye
|
fgf1
|
|
tropicalis
|
NF stage 28
|
olfactory placode
,
otic vesicle
,
forebrain
,
ventricular zone
,
eye
,
[+]
|
fgf1
|
|
tropicalis
|
NF stage 35 and 36
|
otic vesicle
,
forebrain
,
hindbrain
,
ventricular zone
,
head region
,
[+]
|
fgf1
|
|
tropicalis
|
NF stage 40
|
fin
,
otic vesicle
,
forebrain
,
hindbrain
,
head
,
[+]
|
fgf6
|
|
tropicalis
|
NF stage 23
to
NF stage 35 and 36
|
head region
,
somite
,
paraxial mesoderm
|
fgf6
|
|
tropicalis
|
NF stage 40
|
head region
,
somite
,
paraxial mesoderm
|
|
|
Figure 2. Analysis of the spatial expression patterns of the fgf1, fgf4, and fgf8 subfamilies. A: Whole mount in situ hybridisations of fgf1 and fgf2 at the indicated stages. B: Whole mount in situ hybridisations of fgf4 and fgf6 at the indicated stages. C: Whole mount in situ hybridisations of fgf8. For stage 10.5, the images are vegetal views; for stage 15, the images are dorsal views; and for stage 23, 28, 35, and 40, the images are lateral views (anterior is left, posterior is right, dorsal is up, and ventral is down). A schematic representation of a Xenopus embryo at stage 28 with the different embryonic tissues labelled is presented in Supp. Figure S3. |
|
|
|
fgf4 (fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 10.5, blastoporal view, dorsal up. |
|
|
|
fgf4 (fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) ) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 23, lateral view, anterior left, dorsal up. |
|
Display additional annotations [+]
|
|
Figure 10. Detail analysis of the expression of the different fgf and fgfr genes in the otic vesicle. A Coronal sections (dorsal up) of whole mount in situ hybridisations staining within the otic vesicle for fgf1, fgf2, fgf3, fgf4, fgf8, fgf10 and fgf20 at stages 28, 35 and 40. B Coronal sections (dorsal up) of whole mount in situ hybridisations staining within the otic vesicle for fgfr1, fgfr2, fgfr3 and fgfr4 at stages 28, 35 and 40.
|
|
|
|
fgf4 (fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 28, lateral view, anterior left, dorsal up. |
|
|
|
fgf4 (fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 35 & 36 lateral view, anterior left, dorsal up. |
|
|
|
fgf4 (fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) ) gene expression in Xenopus tropicalis embryo, assayed via in situ hybridization, NF stage 40, lateral view, anterior left, dorsal up. |